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Cited by 15Alcohol Consumption and Health EffectsHepatocellular Carcinoma Treatment and PrognosisPharmacogenetics and Drug Metabolism

The Defective Allele of Aldehyde Dehydrogenase 2 Gene is Associated with Favorable Postoperative Prognosis in Hepatocellular Carcinoma

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Huang, Po-Han, Hu, Ching-Chih, Chien, Cheng-Hung, Chen, Li-Wei, Chien, Rong-Nan, Lin, Yi-Shiuan, Chao, Mei, Lin, Chih-Lang +1 more·2019·Journal of Cancer
DOI 10.7150/jca.33221PMC PMC6843870
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Abstract

Background: The Aldehyde dehydrogenase 2 (ALDH2) mutant genotypes contain an allele encoding defective ALDH2 with reduced efficacy of alcohol metabolism leading to accumulation of highly toxic and carcinogenic acetaldehyde.It can induce unpleasant "Asian flush syndrome" and associate with increased risk of cancers.However, to date, little is known about ALDH2 genotypes in relation to the postoperative prognosis of hepatocellular carcinoma (HCC).Methods: From 2002 to 2012, 419 HCC patients receiving surgical resection of HCC were enrolled for ALDH2-rs671 genotyping and outcome correlation.Results: Of the patients included, 202 were ALDH2-rs671 "GG" (wild type) and 217 were mutant (defective) "AA" + "GA" genotype.Kaplan-Meier analysis indicated that "GG" genotype significantly associated with shorter metastasis-free (P = 0.034) and overall (P = 0.005) survival, but not recurrence-free survival (P = 0.281).Univariate followed by multivariate Cox proportional hazard analysis showed that "GG" genotype was an independent clinical predictor for shorter time-to-distant metastasis (adjusted P = 0.019) and shorter overall survival (adjusted P = 0.001).Subgroup analysis showed that in patients with negative hepatitis B surface antigen, Edmonson's histology grade < 3, and aspartate transaminase > alanine transaminase, the ALDH2-rs671-GG genotype was associated with both shorter time-to-metastasis and shorter overall survival.Conclusions: HCC patients carrying a defective allele of ALDH2 had a favorable postoperative outcome.

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  • ALDH2*2 allele is associated with a high incidence of liver cancer in heavy drinkers.

    “The ALDH2 mutant genotype, ALDH2*2 allele (also known as ALDH2(E487K) or ALDH2 rs671 polymorphism), has been found to be associated with a high incidence of liver cancer in heavy drinkers [118,119,120].”

    From Pathophysiological Aspects of Alcohol Metabolism in the Liver (2021) · cites this paper as [120]

    The Introduction identifies ALDH2*2 as the defective allele that causes acetaldehyde to accumulate after drinking. The Discussion says the mutant genotype may be implicated in liver-cancer development, including with alcohol ingestion, but describes the evidence on cancer occurrence as inconsistent. This paper studies prognosis in people already diagnosed with liver cancer; it does not establish a high incidence among heavy drinkers carrying ALDH2*2. (LLM, conf=0.82)

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Research works printed but not linked: 24

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Authors
Huang, P.-H., Hu, C.-C., Chien, C.-H., Chen, L.-W., Chien, R.-N., Lin, Y.-S., Chao, M., Lin, C.-L., & Yeh, C.-T.
Affiliations
Chang Gung University (TW)
Corresponding author
Yeh, Chau-Ting
ORCID
Venue
Journal of Cancer
Publisher
Ivyspring International Publisher
Published
2019
Volume
10
Issue
23
Pages
5735-5743
ISSN
1837-9664 (ISSN-L)
DOI
10.7150/jca.33221
PMC
PMC6843870
OpenAlex
W2982670491
Cited by
15
References
31
Citations by year
2026: 1 · 2025: 2 · 2024: 4 · 2023: 2 · 2022: 2 · 2021: 3 · 2020: 1
FWCI
1.10
Type
journal article
Language
en
Open access
Licence
cc-by
Locations
  • Journal of Cancer (publishedVersion, cc-by)
  • Europe PMC (PubMed Central) (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Pathology and Forensic Medicine › Alcohol Consumption and Health Effects
  • Health Sciences › Medicine › Hepatology › Hepatocellular Carcinoma Treatment and Prognosis
  • Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmacology › Pharmacogenetics and Drug Metabolism
Keywords
ALDH2, ALDH2 rs671, hepatocellular carcinoma, postoperative prognosis, surgical resection, metastasis-free survival, overall survival, acetaldehyde, genetic polymorphism, hepatitis B surface antigen

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