Exosomes from human umbilical cord blood accelerate cutaneous wound healing through miR-21-3p-mediated promotion of angiogenesis and fibroblast function
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Our results suggest that UCB-Exos are important effectors of plasma activity and can be used as a novel promising strategy for soft tissue wound healing.
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Extracellular miRNAs can exert biological functions in recipient cells to regulate their activity, thereby acting as intercellular signaling molecules.
“Many studies have also demonstrated that extracellular miRNAs can exert biological functions in recipient cells to regulate their activity, thereby acting as intercellular signaling molecules.”
From Overview of MicroRNA Biogenesis, Mechanisms of Actions, and Circulation (2018) · cites this paper as [135]
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References 31 · Cited by 574
- Authors
- Hu, Y., Rao, S.-S., Wang, Z.-X., Cao, J., Tan, Y.-J., Luo, J., Li, H.-M., Zhang, W.-S., Chen, C.-Y., & Xie, H.
- Affiliations
- Central South University (CN)
- Corresponding author
- Chen, Chun-Yuan
- Xie, Hui
- Venue
- Theranostics
- Publisher
- Ivyspring International Publisher
- Published
- 2018
- Volume
- 8
- Issue
- 1
- Pages
- 169-184
- ISSN
- 1838-7640 (ISSN-L)
- PMC
- PMC5743467
- OpenAlex
- W2770714340
- Cited by
- 574
- References
- 31
- Citations by year
- 2026: 45 · 2025: 81 · 2024: 73 · 2023: 76 · 2022: 84 · 2021: 86 · 2020: 65 · 2019: 44 · 2018: 19
- FWCI
- 14.30
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- cc-by-nc
- Locations
- Theranostics (publishedVersion, cc-by-nc)
- PubMed Central (publishedVersion, cc-by-nc)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Extracellular vesicles in disease
- Health Sciences › Medicine › Rehabilitation › Wound Healing and Treatments
- Health Sciences › Medicine › Genetics › Mesenchymal stem cell research
- Keywords
- exosomes, umbilical cord blood, skin wound healing, miR-21-3p, angiogenesis, fibroblast function, soft tissue wound healing, extracellular vesicles
- MeSH terms
- Animals, Cell Movement, Cells, Cultured, Fetal Blood, Fibroblasts, Humans, Male, Mice, Inbred C57BL, Wound Healing, Neovascularization, Physiologic, MicroRNAs, Cell Proliferation, Mice, Exosomes
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