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Cited by 214Cancer, Hypoxia, and MetabolismMitochondrial Function and PathologyAutophagy in Disease and Therapy

Endocytosis-mediated mitochondrial transplantation: Transferring normal human astrocytic mitochondria into glioma cells rescues aerobic respiration and enhances radiosensitivity

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Sun, Chao, Liu, Xiongxiong, Wang, Bing, Wang, Zhenhua, Liu, Yang, Di, Cuixia, Si, Jing, Li, Hongyan +7 more·2019·Theranostics
DOI 10.7150/thno.33100PMC PMC6587163
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Abstract

signaling could be a new mechanism of mitochondrial transplantation to rescue aerobic respiration and attenuate the Warburg effect. This mechanism could be a promising approach for radiosensitization.

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  • The CD38-cADPR signaling pathway is involved in mitochondrial internalization, catalyzing the cyclization of extracellular NAD+ into intracellular cADPR, triggering the release of Ca2+, and promoting cytoskeleton remodeling, thus facilitating the internalization of extracellular mitochondria.

    “Additionally, the CD38‐cADPR signaling pathway is involved in mitochondrial internalization, catalyzing the cyclization of extracellular nicotinamide adenine dinucleotide (NAD+) into intracellular cADPR, triggering the release of Ca2+, and promoting cytoskeleton remodeling, thus facilitating the internalization of extracellular mitochondria [62].”

    From Aerobic exercise improves astrocyte mitochondrial quality and transfer to neurons in a mouse model of Alzheimer's disease (2025) · cites this paper as [62]

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Cited by

Sorted by citations

Authors
Sun, C., Liu, X., Wang, B., Wang, Z., Liu, Y., Di, C., Si, J., Li, H., Wu, Q., Xu, D., Li, J., Li, G., Wang, Y., Wang, F., & Zhang, H.
Affiliations
  • Chinese Academy of Sciences (CN)
  • National Institutes for Quantum Science and Technology (JP)
  • Yantai University (CN)
Corresponding author
Zhang, Hong
ORCID
Venue
Theranostics
Publisher
Ivyspring International Publisher
Published
2019
Volume
9
Issue
12
Pages
3595-3607
ISSN
1838-7640 (ISSN-L)
DOI
10.7150/thno.33100
PMC
PMC6587163
OpenAlex
W2952074033
Cited by
214
References
2
Citations by year
2026: 29 · 2025: 39 · 2024: 40 · 2023: 34 · 2022: 24 · 2021: 27 · 2020: 18 · 2019: 3
FWCI
5.57
Type
journal article
Language
en
Open access
Licence
cc-by-nc
Locations
  • Theranostics (publishedVersion, cc-by-nc)
  • Europe PMC (PubMed Central) (publishedVersion, cc-by-nc)
  • PubMed Central (publishedVersion, cc-by-nc)
  • PubMed (publishedVersion)
  • Institutional Repositories DataBase (IRDB) (submittedVersion, cc-by-nc-nd)
  • QST-Repository (National Institutes for Quantum and Radiological Science and Technology) (submittedVersion, cc-by-nc-nd)
Funders
Natural Science Foundation of Gansu Province
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer, Hypoxia, and Metabolism
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mitochondrial Function and Pathology
  • Health Sciences › Medicine › Epidemiology › Autophagy in Disease and Therapy
Keywords
mitochondrial transplantation, endocytosis, astrocytes, glioma cells, aerobic respiration, Warburg effect, radiosensitization, mitochondrial signaling
MeSH terms
Aerobiosis, Animals, Astrocytes, Disease Models, Animal, Endocytosis, Glioma, Humans, Mice, Nude, Mitochondria, Models, Biological, Neoplasm Transplantation, Radiation Tolerance, Transplantation, Heterologous, Cell Respiration, Cell Line, Tumor, Cellular Reprogramming

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