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Competitive Performance of Carbon “Quantum” Dots in Optical Bioimaging
Open accessAbstract
Carbon-based "quantum" dots or carbon dots are surface-functionalized small carbon nanoparticles. For bright fluorescence emissions, the carbon nanoparticles may be surface-doped with an inorganic salt and then the same organic functionalization. In this study, carbon dots without and with the ZnS doping were prepared, followed by gel-column fractionation to harvest dots of 40% and 60% in fluorescence quantum yields, respectively. These highly fluorescent carbon dots were evaluated for optical imaging in mice, from which bright fluorescence images were obtained. Of particular interest was the observed competitive performance of the carbon dots in vivo to that of the well-established CdSe/ZnS QDs. The results suggest that carbon dots may be further developed into a new class of high-performance yet nontoxic contrast agents for optical bioimaging.
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Cites
One-step synthesis of fluorescent carbon nanoparticles by laser irradiation
Hu, S.-L., Niu, K.-Y., Sun, J., Yang, J., Zhao, N.-Q., & Du, X.-W. (2009) · J. Mater. Chem. · doi:10.1039/b812943f · Cited by 968
Cited by
Carbon quantum dots and their applications
Lim, S. Y., Shen, W., & Gao, Z. (2015) · Chemical Society Reviews · doi:10.1039/c4cs00269e · Cited by 4,976
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Zheng, X. T., Ananthanarayanan, A., Luo, K. Q., & Chen, P. (2015) · Small · doi:10.1002/smll.201402648 · Cited by 2,190
Nanomaterials for In Vivo Imaging
Smith, B. R., & Gambhir, S. S. (2017) · Chemical Reviews · doi:10.1021/acs.chemrev.6b00073 · Cited by 1,075
Carbon quantum dots: Preparation, optical properties, and biomedical applications
Yang, H.-L., Bai, L.-F., Geng, Z.-R., Chen, H., Xu, L.-T., Xie, Y.-C., Wang, D.-J., Gu, H.-W., & Wang, X.-M. (2023) · Materials Today Advances · doi:10.1016/j.mtadv.2023.100376 · Cited by 409
Self-citationHyaluronic acid and its derivatives in drug delivery and imaging: Recent advances and challenges
Tripodo, G., Trapani, A., Torre, M. L., Giammona, G., Trapani, G., & Mandracchia, D. (2015) · European Journal of Pharmaceutics and Biopharmaceutics · doi:10.1016/j.ejpb.2015.03.032 · Cited by 286
Metadata
- Authors
- Cao, L., Yang, S.-T., Wang, X., Luo, P. G., Liu, J.-H., Sahu, S., Liu, Y., & Sun, Y.-P.
- Venue
- Theranostics
- Publisher
- Ivyspring International Publisher
- Published
- 2012
- Volume
- 2
- Issue
- 3
- Pages
- 295-301
- ISSN
- 1838-7640 (ISSN-L)
- OpenAlex
- W2114641478
- Cited by
- 180
- References
- 1
- FWCI
- 7.10
- Type
- journal article
- Language
- en
- Open access
- gold
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- Cao, L., Yang, S.-T., Wang, X., Luo, P. G., Liu, J.-H., Sahu, S., Liu, Y., & Sun, Y.-P. (2012). Competitive Performance of Carbon “Quantum” Dots in Optical Bioimaging. Theranostics. https://doi.org/10.7150/thno.3912
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