Quantitative ultrasound approaches for diagnosis and monitoring hepatic steatosis in nonalcoholic fatty liver disease
Open accessAbstract
Nonalcoholic fatty liver disease is a major global health concern with increasing prevalence, associated with obesity and metabolic syndrome. Recently, quantitative ultrasound-based imaging techniques have dramatically improved the ability of ultrasound to detect and quantify hepatic steatosis. These newer ultrasound techniques possess many inherent advantages similar to conventional ultrasound such as universal availability, real-time capability, and relatively low cost along with quantitative rather than a qualitative assessment of liver fat. In addition, quantitative ultrasound-based imaging techniques are less operator dependent than traditional ultrasound. Here we review several different emerging quantitative ultrasound-based approaches used for detection and quantification of hepatic steatosis in patients at risk for nonalcoholic fatty liver disease. We also briefly summarize other clinically available imaging modalities for evaluating hepatic steatosis such as MRI, CT, and serum analysis.
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Two-dimensional shear wave elastography and point shear wave elastography show a similar ability to assess the degree of fibrosis as VCTE.
“They show a similar ability to assess the degree of fi brosis as VCTE.”
From EASL-EASD-EASO Clinical Practice Guidelines on the management of metabolic dysfunction-associated steatotic liver disease (MASLD). (2024) · cites this paper as [154]
The ‘Elastography metrics’ section says that transient elastography and shear wave elastography are both used to classify hepatic fibrosis. It does not establish that two-dimensional and point shear wave elastography have similar diagnostic ability to VCTE; the cited comparison in the References is between the two shear wave methods, not VCTE. (LLM, conf=0.84)
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References 119 · Cited by 165
- Authors
- Pirmoazen, A. M., Khurana, A., El Kaffas, A., & Kamaya, A.
- Affiliations
- Stanford Medicine (US)
- University of Kentucky (US)
- Corresponding author
- Kamaya, Aya
- Venue
- Theranostics
- Publisher
- Ivyspring International Publisher
- Published
- 2020
- Volume
- 10
- Issue
- 9
- Pages
- 4277-4289
- ISSN
- 1838-7640 (ISSN-L)
- PMC
- PMC7086372
- OpenAlex
- W3012775100
- Cited by
- 165
- References
- 119
- Citations by year
- 2026: 15 · 2025: 35 · 2024: 42 · 2023: 25 · 2022: 24 · 2021: 19 · 2020: 5
- FWCI
- 2.67
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- cc-by
- Locations
- Theranostics (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Epidemiology › Liver Disease Diagnosis and Treatment
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Ultrasound Imaging and Elastography
- Health Sciences › Medicine › Critical Care and Intensive Care Medicine › Ultrasound in Clinical Applications
- Keywords
- non-alcoholic fatty liver disease, hepatic steatosis, quantitative ultrasound, liver fat quantification, obesity, metabolic syndrome, liver imaging, magnetic resonance imaging, CT, serum biomarkers, disease surveillance
- MeSH terms
- Biopsy, Humans, Liver, Magnetic Resonance Imaging, Ultrasonography, Non-alcoholic Fatty Liver Disease
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