Dysregulated Expression of Monoacylglycerol Lipase Is a Marker for Anti-Diabetic Drug Metformin-Targeted Therapy to Correct Impaired Neurogenesis and Spatial Memory in Alzheimer’s Disease
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Our findings set the stage for development of a clinical protocol where Mgll would serve as a biomarker in early stages of AD to identify potential metformin-responsive AD patients to restore their neurogenesis and spatial memory.
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Data indicate that metformin targets monoacylglycerol lipase, an enzyme responsible for generating pro-inflammatory eicosanoids from 2-arachidonoyl glycerol, providing potential to use metformin to treat Alzheimer's.
“The potential to use metformin to treat Alzheimer’s is also provided by data indicating that metformin targets monoacylglycerol lipase, an enzyme responsible for generating pro-inflammatory eicosanoids from 2-arachidonoyl glycerol (258).”
From A Critical Review of the Evidence That Metformin Is a Putative Anti-Aging Drug That Enhances Healthspan and Extends Lifespan (2021) · cites this paper as [258]
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References 1 · Cited by 42
Research works printed but not linked: 2
- [29]Koenig AM Mechanic-Hamilton D Xie SX Combs MF Cappola AR Xie L Effects of the insulin sensitizer metformin in Alzheimer disease: Pilot data from a randomized placebo-controlled crossover study Alzheimer Dis Assoc Disord 2017 31 107 13 28538088 PMC5476214
- [50]Grabner GF Eichmann TO Wagner B Gao Y Farzi A Taschler U Deletion of monoglyceride lipase in astrocytes attenuates lipopolysaccharide-induced neuroinflammation J Biol Chem 2016 291 913 23 26565024 PMC4705409
- Authors
- Syal, C., Kosaraju, J., Hamilton, L., Aumont, A., Chu, A., Sarma, S. N., Thomas, J., Seegobin, M., Dilworth, F. J., He, L., Wondisford, F. E., Zimmermann, R., Parent, M., Fernandes, K., & Wang, J.
- Affiliations
- University of Ottawa (CA)
- Ottawa Hospital Research Institute (CA)
- Université de Montréal (CA)
- Johns Hopkins University (US)
- Rutgers, The State University of New Jersey (US)
- University of Graz (AT)
- Université Laval (CA)
- Corresponding author
- Wang, Jing
- ORCID
- Venue
- Theranostics
- Publisher
- Ivyspring International Publisher
- Published
- 2020
- Volume
- 10
- Issue
- 14
- Pages
- 6337-6360
- ISSN
- 1838-7640 (ISSN-L)
- PMC
- PMC7255032
- OpenAlex
- W3026217555
- Cited by
- 42
- References
- 1
- Citations by year
- 2026: 2 · 2025: 2 · 2024: 16 · 2023: 7 · 2022: 10 · 2021: 5
- FWCI
- 3.31
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- cc-by
- Locations
- Theranostics (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Funders
- National Institute of Diabetes and Digestive and Kidney Diseases (R01DK107641, R01DK120309)
- Topics
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Keywords
- monoacylglycerol lipase, monoglyceride lipase, metformin, Alzheimer's disease, neurogenesis, spatial memory, biomarkers, early Alzheimer's disease
- MeSH terms
- Alzheimer Disease, Animals, Disease Models, Animal, Female, Hippocampus, Humans, Hypoglycemic Agents, Male, Metformin, Mice, Transgenic, Monoacylglycerol Lipases, Protein Kinase C, Biomarkers, CREB-Binding Protein, Mice, Neurogenesis, Spatial Memory
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