Exosome-based Ldlr gene therapy for familial hypercholesterolemia in a mouse model
Open accessAbstract
mouse. Our study provided a new therapeutic approach for the treatment of FH patients and managing atherosclerosis.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Passive pre-loading methods have high efficiency due to the natural packaging of desired mRNA into exosomes by donor cells.
“This technique is highly efficient because the donor cells naturally package the desired mRNA into the exosomes. Several studies have utilized this method to load various types of mRNA into exosomes [96].”
From Exosome for mRNA delivery: Strategies and therapeutic applications (2024) · cites this paper as [96]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
The citation lists haven’t been fetched yet
References 46 · Cited by 108
- Authors
- Li, Z., Zhao, P., Zhang, Y., Wang, J., Wang, C., Liu, Y., Yang, G., & Yuan, L.
- Affiliations
- Tang Du Hospital (CN)
- Beijing Tongren Hospital (CN)
- Air Force Medical University (CN)
- Corresponding author
- Yang, Guodong
- Yuan, Lijun
- Venue
- Theranostics
- Publisher
- Ivyspring International Publisher
- Published
- 2021
- Volume
- 11
- Issue
- 6
- Pages
- 2953-2965
- ISSN
- 1838-7640 (ISSN-L)
- PMC
- PMC7806494
- OpenAlex
- W3120744305
- Cited by
- 108
- References
- 46
- Citations by year
- 2026: 16 · 2025: 15 · 2024: 26 · 2023: 18 · 2022: 21 · 2021: 12
- FWCI
- 6.04
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- cc-by
- Locations
- Theranostics (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Extracellular vesicles in disease
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA Interference and Gene Delivery
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Virus-based gene therapy research
- Keywords
- exosomes, familial hypercholesterolemia, atherosclerosis, mouse model, cholesterol metabolism
- MeSH terms
- Animals, Cell Line, Disease Models, Animal, Humans, Hyperlipoproteinemia Type II, Liver, Mice, Inbred C57BL, Receptors, LDL, RNA, Messenger, Genetic Therapy, Atherosclerosis, Mice, Exosomes, HEK293 Cells, Plaque, Atherosclerotic
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
