Electroacupuncture ameliorates intestinal inflammation by activating α7nAChR-mediated JAK2/STAT3 signaling pathway in postoperative ileus
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receptor in DMV neurons, whose excited vagal nerve, in turn suppressed IM-induced inflammation via activation of α7nAChR-mediated JAK2/STAT3 signaling pathway.
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Acetylcholinergic neurons are the major neuron type in the DMV of brain.
“It is well known that acetylcholinergic neurons are the major neuron type in the DMV of brain.[ 23 ]”
From Electroacupuncture Promotes Liver Regeneration by Activating DMV Acetylcholinergic Neurons-Vagus-Macrophage Axis in 70% Partial Hepatectomy of Mice (2024) · cites this paper as [23]
The Discussion identifies ChAT-expressing vagal efferent neurons in the DMV, and the Results study cholinergic neurons there. Neither section says cholinergic neurons are the DMV’s major neuron type. The Results’ statement that a majority of cholinergic neurons showed GABAA-receptor colocalization does not establish their proportion among all DMV neurons. (LLM, conf=0.84)
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Cites
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The autonomic nervous system: A potential link to the efficacy of acupuncture
Li, Y.-W., Li, W., Wang, S.-T., Gong, Y.-N., Dou, B.-M., Lyu, Z.-X., Ulloa, L., Wang, S.-J., Xu, Z.-F., & Guo, Y. (2022) · Frontiers in Neuroscience · doi:10.3389/fnins.2022.1038945 · Cited by 141 · see citing works
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- Authors
- Yang, N.-N., Yang, J.-W., Ye, Y., Huang, J., Wang, L., Wang, Y., Su, X.-T., Lin, Y., Yu, F.-T., Ma, S.-M., Qi, L.-Y., Lin, L.-L., Wang, L.-Q., Shi, G.-X., Li, H.-P., & Liu, C.-Z.
- Affiliations
- Beijing University of Chinese Medicine (CN)
- Corresponding author
- Liu, Cun-Zhi
- ORCID
- Venue
- Theranostics
- Publisher
- Ivyspring International Publisher
- Published
- 2021
- Volume
- 11
- Issue
- 9
- Pages
- 4078-4089
- ISSN
- 1838-7640 (ISSN-L)
- PMC
- PMC7977469
- OpenAlex
- W3139490156
- Cited by
- 204
- References
- 4
- Citations by year
- 2026: 37 · 2025: 59 · 2024: 40 · 2023: 36 · 2022: 26 · 2021: 6
- FWCI
- 31.25
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- cc-by
- Locations
- Theranostics (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Complementary and alternative medicine › Acupuncture Treatment Research Studies
- Life Sciences › Neuroscience › Neurology › Vagus Nerve Stimulation Research
- Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
- Keywords
- electroacupuncture, intestinal inflammation, postoperative ileus, alpha7 nicotinic acetylcholine receptor, JAK2/STAT3 signaling, dorsal motor nucleus of the vagus, vagus nerve, intestinal motility
- MeSH terms
- Animals, Inflammation, Intestines, Macrophages, Mice, Inbred C57BL, Parasympathetic Nervous System, Postoperative Complications, Vagus Nerve, Signal Transduction, Electroacupuncture, Cytokines, Ileus, STAT3 Transcription Factor, Mice, Janus Kinase 2, alpha7 Nicotinic Acetylcholine Receptor
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