Chondrocyte-specific genomic editing enabled by hybrid exosomes for osteoarthritis treatment

Liang, Yujie, Xu, Xiao, Xu, Limei, Iqbal, Zoya, Ouyang, Kan, Zhang, Huawei, Wen, Chunyi, Duan, Li +1 more·2022·Theranostics

Cited by (218)

Items 101–200 of 218

  1. Bioengineering of extracellular vesicles with scaffold proteins for drug delivery
    Chaofan Zhang, Yue Wu, Yuezhou Wang, Cunbo Yao, Mengting Ma, Jiacong Li, Qiang Wu · 2026 · Journal of Nanobiotechnology
  2. Combinatory Nanovesicle with siRNA-Loaded Extracellular Vesicle and IGF-1 for Osteoarthritis Treatments
    Jun Yong Kim, Seung Yeon Lee, Seung-Gyu Cha, Jung Min Park, Duck Hyun Song, Sang‐Hyuk Lee, Dong‐Youn Hwang, Byoung‐Ju Kim, Seungsoo Rho, Chun Gwon Park et al. · 2024 · International Journal of Molecular Sciences
  3. Extracellular vesicles as nanomaterial carriers: Endowing superior targeting capability and biosafety
    Hengshuo Gui, Wenqi Wang, Yuhao Xue, Wenhui Zhao, Min Wang, Lei Shi, Xianwen Wang · 2025 · Coordination Chemistry Reviews
  4. Engineered red blood cell extracellular vesicles for delivery of Dox and siIDO1 enhance targeted chemo-immunotherapy of acute myeloid leukemia
    Yongcan Liu, Jiayuan Hu, Yan Shu, Genyou Li, Fangfang Jin, Jun Ren, Jing Yang, Can Lin, Lisha Tang, Xingyu Wei et al. · 2025 · Journal for ImmunoTherapy of Cancer
  5. Engineered small extracellular vesicles as bioactive materials: Integrating engineering strategies for cargo loading and targeted delivery systems
    Hongtao Xu, Rui Liu, Hao Zhou, Bin Kong, Kai Shen, Tao Zhao, Xiaofeng Du, Hao Zhang, Huanghe Song, Dunming Guo et al. · 2025 · Bioactive Materials
  6. Shape Engineering of Exosomes for Endoplasmic Reticulum-Targeted Delivery and Amplified Anticancer Efficacy
    Liang Li, Ning Wang, Xiang Li, Zhuan Zhang, Zhu Zhu, Yan Zhuo, Xiaohe Jiang, Jie Wang, Cong Guo, Cong Guo et al. · 2024 · Nano Today
  7. Exosomes promise better bone regeneration
    Shuaiwen Hu, Shaogeng Wang, Xiaomao Yang, Ping Li, Zhiguo Li, Bin Luo, Yujie Liang, Xiaohua Pan · 2025 · Regenerative Therapy
  8. Global research trends in CRISPR-related technologies associated with extracellular vesicles from 2015 to 2022: a bibliometric, dynamic, and visualized study
    Jianjing Lin, Shicheng Jia, Zilu Jiao, Jiayou Chen, Wei Li, Fuyang Cao, Xintao Zhang · 2023 · Cellular & Molecular Biology Letters
  9. Molecular imaging-guided extracellular vesicle-based drug delivery for precise cancer management: Current status and future perspectives
    Zhongquan Cheng, Jihuan Shang, Huarong Wang, Leyi Yu, Yuan Zhu, Yinlong Zhang, Yang Du, Jie Tian · 2023 · Journal of Controlled Release
  10. Extracellular vesicles as natural nanocarriers: From in vitro engineering to in situ generation in cancer therapy
    Teng Zhang, Zimai Liu, Yuanyuan Wei, Jiao Lu, Zonghong He, Zixian Wu, Meiyi Liu, Kai Li, Xiaoxi Wang, Zhengwei Li et al. · 2025 · Chemical Engineering Journal
  11. In vivo delivery systems for CRISPR genome editing: Viral and non-viral carriers
    Yeeun Lee, Bookun Kim, Donghyun Lee, Seo Young Cheon, Seong Gi Lim, Younggwang Kim, Heebeom Koo · 2025 · Applied Physics Reviews
  12. The Application of Novel Drug Delivery Systems in the Treatment of Osteoarthritis
    Pengfei Huang, Junjie Zhao, Xiyu Wang, Zhaokun Zhang, Haiyan Zhao · 2025 · Pharmaceutics
  13. The Role of Extracellular Vesicles in Musculoskeletal Diseases
    Peng‐jie Fu, Yan Luo, Shengyuan Zheng, Ziqian Ma, Wenfeng Xiao, Hui Li, Yu‐sheng Li · 2025 · Journal of Extracellular Vesicles
  14. Synovia tissue-specific exosomes participate in the dual variation of the osteoarthritis microenvironment via miR-182
    Shiqiang Wu, Jun Luo, Xiaolu Zhang, Liangmin Wang, Liquan Cai, Jie Xu · 2024 · Experimental Cell Research
  15. Long-Acting Extracellular Vesicle-Based Biologics in Osteoarthritis Immunotherapy
    Philip C. Drohat, Max Baron, Lee D. Kaplan, Thomas Michael Best, Dimitrios Kouroupis · 2025 · Bioengineering
  16. Engineered Extracellular Vesicles in Arthritic Diseases: Therapeutic Applications & Challenges
    Seif Ehab, Ola A. Gaser, Atif Abdulwahab A. Oyouni, Nader Kameli, Faisal A. Alzahrani, Ahmed Abdal Dayem · 2025 · Wiley Interdisciplinary Reviews Nanomedicine and Nanobiotechnology
  17. Round window membrane extracellular vesicles facilitate inner ear drug delivery
    S Holdsclaw, Dylan Silkstone, Farimah Moazzam, Haven Jeanneret, N Tehsin, E. Norris, E Talic, Kristen D. Popowski, Glenn Cruse, Ke Cheng et al. · 2025 · Journal of Controlled Release
  18. Targeting WNT signalling pathways as new therapeutic strategies for osteoarthritis
    Zoya Iqbal, Jiang Xia, Ghulam Murtaza, Maryam Shabbir, Khurrum Rehman, Liang Yujie, Li Duan · 2023 · Journal of drug targeting
  19. Multifunctional liposomes for staged osteoarthritis therapy: From symptom management to regeneration
    Qing Yao, Zhuoxun Huang, Fuxiang Shangguan, Longfa Kou, Jian Ding, R. Chen · 2026 · Colloids and Surfaces B Biointerfaces
  20. Analysis of genetic biomarkers, polymorphisms in ADME-related genes and their impact on pharmacotherapy for prostate cancer
    Khurram Rehman, Zoya Iqbal, Zhiqin Deng, Hina Ayub, Naseem Saba, Muzammil Ahamd Khan, Liang Yujie, Li Duan · 2023 · Cancer Cell International
  21. Harnessing Engineered Extracellular Vesicles from Mesenchymal Stem Cells as Therapeutic Scaffolds for Bone‐Related Diseases
    Tingting Yu, Jingwei Wang, Yusai Zhou, Chao Ma, Rushui Bai, Cancan Huang, Shidong Wang, Kai Liu, Bing Han · 2024 · Advanced Functional Materials
  22. A microsphere loaded with chondrocyte-targeting exosomes continuously deliver miR-148a for osteoarthritis therapy
    Tao Yang, Haiwei Ma, Kechi Li, Jie Xiang, Jianxin Qiu, Yiming Ding, Chengdi Wang, Hehuan Lai, Xingyu Hu, Shijie Liu et al. · 2025 · Materials Today Bio
  23. A self-assembled nano micelle-exosome with high selectivity and penetrability achieves precise intracartilage lipid delivery
    Ming-Yang Li, Limin Wu, Huiqi Xie, Bin Shen · 2025 · Science Advances
  24. Advances in nanomaterial-mediated CRISPR/Cas delivery: from lipid nanoparticles to vesicle-derived systems
    B Wang, Jingyuan Lu, Xiaoyi Zhang, Raymond Hu, Haowei Ma · 2026 · Frontiers in Bioengineering and Biotechnology
  25. Unleashing the potential of mRNA : Overcoming delivery challenges with nanoparticles
    Qiang Chen, Ku-Geng Huo, Sheng‐Min Ji, Shude Pang, Tianying Sun, Yi Niu, Zi‐Hao Jiang, Peng Zhang, Shu‐Xin Han, Jinyao Li · 2024 · Bioengineering & Translational Medicine
  26. A novel member of biomimetic nano vesicles: Functional properties and research progress of hybrid-membered nanovesicles
    Chao Zhang, Yan Liu, Tianliang Bai, Huming Shao, Ziyi Xiong, Michelle M. Epstein, Xin Li, Hongbing Chen · 2025 · Biotechnology Advances
  27. Surface-Engineered Umbilical Cord Mesenchymal Stem Cell-Derived sEVs for Targeted Therapy of Osteoarthritis
    Yujun Sun, Haoyu Wu, Junxi Chen, Chunyu Xue, Jiankai Luo, Jionglin Wu, Shixun Li, Changchuan Li, Taihe Liu, Chenhao Pan et al. · 2025 · ACS Biomaterials Science & Engineering
  28. The Role of Exosomes as Endogenous Nanocarriers for Targeted Drug Delivery: Isolation, Engineering, and Clinical Progress in Neurological and Other Diseases
    Xue-Qing null Liu, Rui null Sheng · 2025 · Journal of Integrative Neuroscience
  29. CRISPR/Cas9 genome editing-based preclinical theranostics, biomarkers and drug delivery systems for cancer applications
    Aseem Setia, Dipali Patil, Nandini Vinodrao Randhave, Vaishali, Nidhi Verma, Komal Rani, Akshay Kale, Bhima Wagh, Vikas Kumar, Ankit Kumar Malik et al. · 2026 · International Journal of Biological Macromolecules
  30. Duhuo Jisheng Decoction regulates intracellular zinc homeostasis by enhancing autophagy via PTEN/Akt/mTOR pathway to improve knee cartilage degeneration
    Ye-Hui Wang, Yi Zhou, Xiang Gao, Sheng Sun, Yizhou Xie, You-Peng Hu, Yang Fu, Xiao-Hong Fan, Quan Xie · 2024 · PLoS ONE
  31. Biologics-based technologies for highly efficient and targeted RNA delivery
    Anastasiya Kostyusheva, Sergey Brezgin, Natalia Ponomareva, Anastasiia Frolova, Alexander Lunin, Баюрова Екатерина Олеговна, Andrey Tikhonov, O. V. Slatinskaya, Polina A. Demina, Artyom Kachanov et al. · 2024 · Molecular Therapy
  32. Comparison of proteomic landscape of extracellular vesicles in pleural effusions isolated by three strategies
    Xue Yao, Baixue Liao, Feng Chen, Lüye Liu, Kaiwen Wu, Yaying Hao, Yanping Li, Yuebin Wang, Ruiling Fan, Jun Yin et al. · 2023 · Frontiers in Bioengineering and Biotechnology
  33. Research progress on exosomes from different sources in osteoarthritis and cartilage injury
    Zilong Yang, Zihao Deng, Wentao Gao, Wei Zhang, Xuxuan Fan, Ke Su, Zhiqin Liu · 2025 · Journal of Orthopaedic Surgery and Research
  34. Cell-penetrating peptide-functionalized biomimetic nanovesicles for efficient cataract treatment via enhanced corneal penetration and lens-mitochondria dual targeting
    Renjie Zhang, Wei Li, Jiahao Wang, Yijin Li, Jiang Chen, Wenxin Hong, Huiying Huang, Quankui Lin · 2025 · Bioactive Materials
  35. Biomimetic Nanomaterials for Osteoarthritis Treatment: Targeting Cartilage, Subchondral Bone, and Synovium
    Xiaoshan Gong, Hao Tang, Jingjin Dai, Guoqiang Wang, Shiwu Dong · 2024 · Advanced NanoBiomed Research
  36. Exosomes in sarcoma: Prospects for clinical applications
    Huali Ye, Linyun Tan, Chongqi Tu, Li Min · 2022 · Critical Reviews in Oncology/Hematology
  37. Recent advances in biomimetic nanodelivery systems for the treatment of osteoporosis
    Zhaozhou Ren, Wan’an Xiao, Tingting Yang, Yanshuo Han, Lunhao Bai, Liang Feng, Jiao Guo, Shuangmei Liu · 2025 · Materials Today Bio
  38. Exosome Augmentation Technologies for Drug Delivery and Disease Treatment: A Review
    Jun Wu, Ruibin Li, Lu Cao, Peiqi Wang, Shiqi Jiang, Yan Chen, Haoxin Fu, Xinhao Xu, Guanyang Lin, Lanjie Lei et al. · 2026 · Biomaterials Research
  39. Precision-targeted nanodelivery systems for intra-articular treatment of knee osteoarthritis: recent breakthroughs and translational challenges
    Yongli Zhao, Yang Gao, Weidong Zhao, Fadong Li, WeiBing Hou, Tiansheng Bu · 2026 · Frontiers in Bioengineering and Biotechnology
  40. Structure-Guided Discovery of Potent and Selective CLK2 Inhibitors for the Treatment of Knee Osteoarthritis
    Yongqiang Sun, Tianxing Hu, Mengdi Zhang, Jiaxing Song, Zhen Qin, Mai Liu, Jinliang Ji, Zhiyu Li, Zhixia Qiu, Jinlei Bian · 2024 · Journal of Medicinal Chemistry
  41. One-Step Formation Method of Plasmid DNA-Loaded, Extracellular Vesicles-Mimicking Lipid Nanoparticles Based on Nucleic Acids Dilution-Induced Assembly
    Kazuya Okami, Shintaro Fumoto, Mana Yamashita, Moe Nakashima, Hirotaka Miyamoto, Shigeru Kawakami, Koyo Nishida · 2024 · Cells
  42. A novel mechanism behind irreversible development of cartilage degradation driven articular cartilage defects revealed by rat model: The chain reaction initiated by extracellular vesicles delivered LOC102546541
    Chengteng Lai, Xi Cheng, Tao Yuan, Peng Fang, Hong Qian, Hui Jiang, Jia Meng, Jianning Zhao, Nirong Bao, Lei Zhang · 2024 · International Immunopharmacology
  43. A programmable arthritis-specific receptor for guided articular cartilage regenerative medicine
    Bonnie L. Walton, Rebecca L. Shattuck-Brandt, Catherine A. Hamann, Victoria W. Tung, Juan Manuel Colazo, David Douglass Brand, Karen A. Hasty, Craig L. Duvall, Jonathan M. Brunger · 2024 · Osteoarthritis and Cartilage
  44. Stem Cell Exosomes for Osteoarthritis in Veterinary Medicine
    S. Amitha Banu, Khan Sharun, Rony S. Emmanuel, Merlin Mamachan, K Manjusha, Sathish Muthu, Hussein M. El‐Husseiny, Rohit Kumar, ABHIJIT MOTIRAM PAWDE, Kuldeep Dhama et al. · 2025 · Stem Cells International
  45. Cargo-driven extracellular vesicles as pharmaceutical nanocarriers: A pharmaceutics-oriented comparison of animal exosomes and plant-derived exosome-like nanoparticles
    Hongfeng Xu, Jin Zhang, Meng Li · 2026 · International Journal of Pharmaceutics X
  46. Engineering exosomal cargo loading via endogenous molecular pathways: Strategies to enhance therapeutic potential
    Huanrong Zhu, Chenning Zhang, Shihan Ma, Zhanxue Xu, Cailing Liang, Fang Cheng, Hao Chen · 2026 · Interdisciplinary medicine
  47. CRISPR-based genetically modified scaffold-free biomaterials for tissue engineering and regenerative medicine
    Yunxuan Chen, Yu Ke, Zhiwei Jiang, Guoli Yang · 2025 · Biomaterials Science
  48. Potential of small extracellular vesicles as Cas9 delivery tool: a promising approach for gene editing livestock gametes and embryos
    Giuliana de Avila Ferronato, Juliano C da Silveira, Marcia de Almeida Monteiro Melo Ferraz · 2025 · Biology of Reproduction
  49. Enhancing osteoporosis treatment: emerging roles of engineered exosomes in bone regeneration and repair
    Hongtao Li, Hongyu Pan, Minshan Feng · 2026 · Journal of Translational Medicine
  50. Engineered Cas9 exosome vesicles as a novel gene editing tool for targeted ASPN editing in osteoarthritis
    Chao Lou, Jinwu Wang, Cheng-Qian Dai, Jilong Wang, Yang Jin, Yuqin Fang, Hongyi Jiang, Xiaoyun Pan, Han Li, Chenhao Lan et al. · 2026 · Journal of Nanobiotechnology
  51. Anatomically Guided Non-Viral CRISPR/Cas9 Delivery in the Eye: Overcoming Barriers for Precision Gene Therapy
    Zhixiang Hua, Yang Shen, Xingtao Zhou · 2026 · Pharmaceutics
  52. Lipid-Based Nanocarriers for Curcumin Delivery: A Promising Strategy in The Management of Inflammatory Diseases
    Joy Sitompul, Maya Nurul Rahma, Fauzan Afandi, Khaled M. Elamin, Ahmed Mohammed, Nasrul Wathoni · 2026 · International Journal of Nanomedicine
  53. Phage Display Screening of Anchor Peptides for Red Blood Cell-Derived Extracellular Vesicles
    Limei Xu, Xiao Xu, Jiang Xia, Huawei Zhang, Yujie Liang, Li Duan · 2024 · ACS Omega
  54. Exosome-Based Drug Delivery Systems
    Ruotong Huang, Jianming Zhou, Shuying Chen · 2025 · Physiology
  55. Global Research Trends in EV-Based Cell-Free Therapy for Osteoarthritis: A Bibliometric Analysis
    Chuanhui Zhang, Chen Xu, Chengshuai Sun, Weining Meng · 2025 · Tissue Engineering and Regenerative Medicine
  56. Nanotechnology-driven strategies for gene therapy of arthritis
    Shuo Wang, Yuequan Wang, Qin Chen · 2025 · Materials Today Bio
  57. Nanobiomaterials for osteoarthritis therapy: Current strategies and future perspectives
    Qianting Ji, Bingqi Zheng, Baolin Huang, Dražen Matičić, Huaqiong Li, Baohua Liu · 2026 · Precision medicine and engineering.
  58. Osteoarthritis: Epidemiology, Diagnosis, and Treatment
    Qin Ru, D Z Yuan, Shide Jiang, Xiaoxuan Zhao, Xin Liu, Yusheng Li, S Liu, Yuxiang Wu · 2026 · MedComm
  59. A comparison of jade moxibustion and traditional moxibustion in the treatment of knee osteoarthritis: A randomized clinical trial
    Yue Yin, Lusheng Chen, Xiangyun Wang, Jing Fang, Ling Zhao, Xueyong Shen · 2023 · Medicine
  60. Exosomes as a window of opportunity in hepatocellular carcinoma: Insights from diagnostic to targeted drug delivery
    S. Gupta, Amitava Deb, Pranab Behari Mazumder, Gyan Singh Shekhawat · 2024 · Journal of Drug Delivery Science and Technology
  61. Mapping the knowledge landscape: A bibliometric analysis of exosome research in osteoarthritis (2004–2023)
    Hui Xu, Zhen Wang, Zheng Wang, Juntao Chen, Chi Zhao, Bingxin Kang, Xirui Xu, Jun Shen, Mengmeng Li, Jieyao Diao et al. · 2024 · Heliyon
  62. Genetically programmable wearable devices for precision physiological and molecular monitoring
    He Jin, Mengdie Fu, Wenyue An, Wenyi Xu, Jiehua Zhou, Yan Chen, ZiChun Xia, Zhiwei Jiang, Guoli Yang · 2025 · Biofabrication
  63. Customized extracellular vesicles targeting lysosomal biogenesis deliver therapeutic cargo for intervertebral disc degeneration treatment
    Zhiwei Liao, Zixuan Ou, Bide Tong, Shuai Li, Yang Cao · 2025 · Journal of Nanobiotechnology
  64. Exosome‐Based Cartilage‐Targeted Delivery System: Strategies and Applications
    Yao Wang, Bo Chen, Haodong Zhu, Zhenyu Sun · 2025 · Small Science
  65. Methods and strategies of bioengineered cell exosomes for the treatment of osteoarthritis
    Chengjun Zhang, Jinming Liu, Shijie Chen, Dacheng Zhao, Changshun Chen, Bin Geng, Yayi Xia · 2025 · Joint Bone Spine
  66. NsPEFs-enriched ADSCs-EVs alleviate osteoarthritis via RSPO3-mediated dual pro-chondrogenic and pro-M2 macrophage properties
    Yushan Wang, Yingjie Gao, Zhiyan Cao, Mingjie Dong, Pengfei Shao, Hao Fan, Zijian Guo, Xiaoyong Hu, Wenxiang Cheng, Pengcui Li et al. · 2026 · Bioactive Materials
  67. Synergistic interplay of dECM and exosomes in shaping the cartilage matrix microenvironment: A new paradigm for regenerative medicine
    Asif Shahriar, Song Chen, Yixuan Amy Pei, Ming Pei · 2026 · Engineered Regeneration
  68. Advancements in Intra‐Articular Drug Delivery Systems for Osteoarthritis Therapy
    Haowen Tian, Jia Deng, Yalin Xu, Na Liu, Xiwei Jiang, Chutong Tian · 2026 · Advanced Therapeutics
  69. Plant-derived extracellular vesicles as a promising nanomedicine platform: engineering strategies and biomedical applications
    Xin Zhang, Yifan Dong, Qing Tian, Yang Yang, Hongda Wang, Min Zhang, Yiuno Li, Xue Li, Qinhua Chen, Dean Guo et al. · 2026 · Chemical Engineering Journal
  70. Application of extracellular vesicles in the CRISPR-based diagnosis and treatment: possibilities and challenges
    Eunhye Cho, Jehyung Lee, Jiyu Kim, Jaewon Choi, Mikyung Kang, Jayeon Song · 2026 · Journal of Biological Engineering
  71. Recent advances in the use of stem cell-derived exosomes for joint regeneration
    Saeedeh Zare Jalise, Naresh Poondla, Sharafaldin Al-Musawi, Mohsen Sheykhhasan · 2026 · Molecular Biology Reports
  72. Bibliometric analysis of research on osteoarthritis and extracellular vesicles: Trends and frontiers
    Yongkang Ding, Liang Lu, Ye Guo, Bing Zhu · 2024 · Heliyon
  73. Application of gene therapy in osteoarthritis
    You Li, Biao Li, András Nagy, Christopher Kim · 2025 · Connective Tissue Research
  74. Revolutionizing animal husbandry: Breakthroughs in gene editing delivery systems
    Yuan Liu, Xue Bai, Xue Feng, Shuang Liu, Yamei Hu, Hongen Chu, Lingkai Zhang, Bei Cai, Yun Ma · 2024 · Gene
  75. Hybrid Cell Membrane Engineered Platform for Theranostic Application
    Meng Sun, Jinfeng Zhang · 2025 · Springer eBooks
  76. Exosomes in Osteoarthritis: Emerging Roles in Pathogenesis, Diagnosis, and Therapeutic Potential
    Abolfazl Bagherifard, Sina Talebi, Ahmad Hemmatyar, Khatere Mokhtari, Hooman Yahyazedeh, Hamid Tanzadehpanah · 2026 · Current Pharmaceutical Design
  77. Hybridization of polysaccharide/lipid composite-based nanovesicles for precise delivery of drug/gene/protein in immunotherapy: A promising paradigm for precision cancer therapy
    Zahra Ghasemi, Ali Reza Maleki, Ramin Sarrami‐Forooshani, Fariborz Sharifianjazi, Ketevan Tavamaishvilid, Seyed Morteza Naghib · 2026 · Carbohydrate Polymers
  78. Virus‐Like Nanoparticles for Vaccine Development and Drug Delivery
    Defeng Li, Meifeng Yang, Ning-ning Yue, Longbin Huang, Chen Kong, Yuan Zhang, Cheng‐mei Tian, Zhao Hai-lan, Qian‐jun Luo, Hua‐lin Ma et al. · 2026 · Reviews in Medical Virology
  79. Liposomes: An Intelligent Drug Delivery System for Translational Applications in Bone Biomedicine
    Weike Feng, Yun Xue, Bin Chang, Chunyang Wang, Ruitang Liu, Yigui Zhou, Longwen Zhan, Qiuming Gao, Bo Fan · 2026 · Journal of Biomedical Materials Research Part B Applied Biomaterials
  80. Smart exosomes: multimodal engineering strategies for logic-gated and stimuli-responsive precision theranostics
    Yuhe Hu, Xue Yang, Fuxing Shu, Leilei Jin, Surendra Sarsaiya, Shiqing Han, Jishuang Chen · 2026 · International Journal of Pharmaceutics
  81. Exosomes in bone health and disease: cellular crosstalk, systemic signaling, and AI-driven advances in regenerative therapy
    Xueying Liu, Wenqing Yu, Chengyu Huang, Zhenmin Wang, Ying Qian, Xin Chen, Gaoyang Chen · 2026 · Stem Cell Research & Therapy
  82. The Multifaceted Role of Extracellular Vesicles in Triple Negative Breast Cancer
    Serena El Rayes, Ebaa Ababneh, Varun Nannuri, Manjusha Vaidya, Kimio Sugaya, Jihe Zhao · 2026 · International Journal of Molecular Sciences
  83. Characterization of the Joint Microenvironment in Osteoarthritic Joints for In Vitro Strategies for MSC-Based Therapies: A Systematic Review
    Aline Silvestrini da Silva, Fernanda Campos Hertel, Fabrício Luciani Valente, Fabiana Azevedo Voorwald, Andréa Pacheco Batista Borges, Adriano de Paula Sabino, Rodrigo Viana Sepúlveda, Emily Correna Carlo Reis · 2024 · Applied Biosciences
  84. Innovative Approaches in Temporomandibular Joint Osteoarthritis: Potentials and Limits of Exosome-Based Therapies
    İpek Necla Güldiken, Tan Fırat Eyüboğlu, Mutlu Özcan · 2025 · Current Oral Health Reports
  85. Comprehensive Analysis of Therapeutic Strategies Using Mesenchymal Stem Cell-Derived Exosomes in Preclinical Models of Osteoarthritis
    Riya Mukherjee, Ramendra Pati Pandey, Gunjan, Himanshu, Ing-Kae Wang, Sing-Ying Hsieh, Chung-Ming Chang · 2024 · medRxiv
  86. Single-Cell Analysis Approaches in Cartilage Diseases Diagnosis and Therapies
    Mahsa Ghorbaninejad, Sara Farahi, Farzaneh Mirzaeian, Fatemeh Khodabandehloo, Samaneh Hosseini, Mohamadreza Baghaban Eslaminejad · 2023 · Springer eBooks
  87. Duhuo Jisheng Decoction Regulates Intracellular Zinc Homeostasis by Enhancing Autophagy via PTEN/Akt/mTOR to Improve Knee Cartilage Degeneration
    Ye-Hui Wang, Yi Zhou, Xiang Gao, Sheng Sun, Yizhou Xie, You-Peng Hu, Yang Fu, Xiaohong Fan, Quan Xie · 2023 · bioRxiv (Cold Spring Harbor Laboratory)
  88. Comprehensive Analysis of Therapeutic Strategies Using Mesenchymal Stem Cell-Derived Exosomes in Preclinical Models of Osteoarthritis
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  89. Potential Applications of the CRISPR-Cas9 System for Research and Treatment of Osteoarthritis
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  90. Engineering Cell Membrane-Derived Nanovesicles for Advanced Biomedical Applications
    Zahid Hussain, Wajiha Ahmed, Tian Gao, Ye Zhang, Renjun Pei · 2025 · Springer eBooks
  91. Extracellular Vesicle–Liposome Hybrid Nanoparticles Delivery of CRISPR/Cas9 Induces a Unique DNA Repair Pattern in the HGF Gene of Stem Cells from Apical Papilla
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  92. A Bibliometric Analysis of Exosomes Associated with Rheumatic Diseases in the 21st Century
    Yuanyuan Zou, Shuwei Wang, Xingyue Ao, Jialu Zhang, Enhao Chen, Jinping Wang, Jing Luo, Qingwen Tao · 2025 · Journal of Multidisciplinary Healthcare
  93. Fat modifications protect joints from degrading
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  94. Additional file 1 of Edible exosome-like nanoparticles from portulaca oleracea L mitigate DSS-induced colitis via facilitating double-positive CD4+CD8+T cells expansion
    Zhu, Min-zheng, Xu, Hao-ming, Liang, Yu-jie, Xu, Jing, Yue, Ning-ning, Zhang, Yuan, Tian, Cheng-mei, Yao, Jun, Wang, Li-sheng, 聂玉强 et al. · 2023 · Figshare
  95. Bridging the gap in OA therapeutics: Bioengineered strategies to target osteoclast–chondrocyte crosstalk
    Enbo Zhang, Chi Ma, Xiaohe Fan, Bowen Gu, Bo Li · 2026 · Bioengineering & Translational Medicine
  96. mRNA therapeutics for inflammatory bone diseases: opportunity and challenge
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  97. Chondrocytes reprogram chromatin in hypoxic microenvironments to activate CADM1-AS1/HDAC1 complex-mediated anti-inflammation signals
    Weiyu Ni, Tianyuan Gu, Panyang Shen, Zixuan Mei, Yizheng Wu, Kamuran Yilamu, Nan Pan, Wentao Yang, Gang Liu, Yan Ma et al. · 2026 · Nature Communications
  98. Functionalization of extracellular vesicles for biomedical applications
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  99. The Multidimensional Regulatory Network of Osteoblast Differentiation and Targeted Therapeutic Strategies for OP
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  100. Mesenchymal stromal cells therapy for remodeling the joint microenvironment: mechanisms, nanotechnology-enhanced strategies, and translation prospects
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