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CC-1065 (NSC-298223), a new antitumor antibiotic. Production, in vitro biological activity, microbiological assays and taxonomy of the producing microorganism.
Open accessAbstract
A new antitumor antibiotic is produced in fermentation liquors of Streptomyces zelensis sp.n. The antibiotic is biologically active at extremely low concentrations. At 40 pg/ml, it inhibited 90% of the growth of L1210 cells in culture in tube dilution assays. The minimal inhibitory concentrations against Gram-positive bacteria is between 1 approximately 10 ng/ml, while these values for Gram-negative bacteria and fungi are mostly under 1 microgram/ml. A microbiological assay with Bacillus subtilis can detect concentrations of 1 approximately 2 ng/ml.
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Cited by
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Nepali, K., Sharma, S., Sharma, M., Bedi, P. M. S., & Dhar, K. L. (2014) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2014.03.018 · Cited by 435
Yao, H.-P., Zhao, H., Hudson, R., Tong, X.-M., & Wang, M.-H. (2021) · Drug Discovery Today · doi:10.1016/j.drudis.2021.06.012 · Cited by 70
Metadata
- Authors
- HANKA, L. J., DIETZ, A., GERPHEIDE, S. A., KUENTZEL, S. L., & MARTIN, D. G.
- Venue
- The Journal of Antibiotics
- Published
- 1978
- Volume
- 31
- Issue
- 12
- Pages
- 1211-1217
- ISSN
- 0021-8820 (ISSN-L)
- 1881-1469
- OpenAlex
- W2064375802
- Cited by
- 272
- References
- 0
- FWCI
- 1.77
- Type
- journal article
- Language
- en
- Open access
- bronze
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- CoChat. (2026). Citation check: CC-1065 (NSC-298223), a new antitumor antibiotic. Production, in vitro biological activity, microbiological assays and taxonomy of the producing microorganism. https://app.cochat.ai/papers/10.7164/antibiotics.31.1211
- The paper
- HANKA, L. J., DIETZ, A., GERPHEIDE, S. A., KUENTZEL, S. L., & MARTIN, D. G. (1978). CC-1065 (NSC-298223), a new antitumor antibiotic. Production, in vitro biological activity, microbiological assays and taxonomy of the producing microorganism. The Journal of Antibiotics. https://doi.org/10.7164/antibiotics.31.1211
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
