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The Discovery of Australifungin, a Novel Inhibitor of Sphinganine N-Acyltransferase from Sporormiella australis. Producing Organism, Fermentation, Isolation, and Biological Activity.
Open accessAbstract
Potent antifungal activity was detected in fermentation extracts of Sporormiella australis and two related components were isolated from solid fermentations using silica gel and high speed countercurrent chromatography. The most active antifungal component, australifungin, contained a unique combination of alpha-diketone and beta-ketoaldehyde functional groups. Australifungin exhibited broad spectrum antifungal activity against human pathogenic fungi with MICs against Candida spp., Cryptococcus neoformans, and Aspergillus spp. between 0.015 and 1.0 microgram/ml. Mode of action studies revealed that australifungin interfered with fungal lipid metabolism by specifically inhibiting sphingolipid synthesis at the step converting sphinganine to ceramide.
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Citations
Cited by
Oh, C.-S., Toke, D. A., Mandala, S., & Martin, C. E. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.28.17376 · Cited by 486
Self-citationGlucosylceramide synthase is an essential regulator of pathogenicity of Cryptococcus neoformans
Rittershaus, P. C. (2006) · Journal of Clinical Investigation · doi:10.1172/jci27890 · Cited by 239
Singh, A., Wang, H., Silva, L. C., Na, C., Prieto, M., Futerman, A. H., Luberto, C., & Del Poeta, M. (2012) · Cellular Microbiology · doi:10.1111/j.1462-5822.2011.01735.x · Cited by 81
Metadata
- Authors
- MANDALA, S. M., THORNTON, R. A., FROMMER, B. R., CUROTTO, J. E., ROZDILSKY, W., KURTZ, M. B., GIACOBBE, R. A., BILLS, G. F., CABELLO, M. A., MARTÍN, I., PELÁEZ, F., & HARRIS, G. H.
- Venue
- The Journal of Antibiotics
- Published
- 1995
- Volume
- 48
- Issue
- 5
- Pages
- 349-356
- ISSN
- 0021-8820 (ISSN-L)
- 1881-1469
- OpenAlex
- W2090508494
- Cited by
- 175
- References
- 0
- FWCI
- 8.06
- Type
- journal article
- Language
- en
- Open access
- bronze
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- CoChat. (2026). Citation check: The Discovery of Australifungin, a Novel Inhibitor of Sphinganine N-Acyltransferase from Sporormiella australis. Producing Organism, Fermentation, Isolation, and Biological Activity. https://app.cochat.ai/papers/10.7164/antibiotics.48.349
- The paper
- MANDALA, S. M., THORNTON, R. A., FROMMER, B. R., CUROTTO, J. E., ROZDILSKY, W., KURTZ, M. B., GIACOBBE, R. A., BILLS, G. F., CABELLO, M. A., MARTÍN, I., PELÁEZ, F., & HARRIS, G. H. (1995). The Discovery of Australifungin, a Novel Inhibitor of Sphinganine N-Acyltransferase from Sporormiella australis. Producing Organism, Fermentation, Isolation, and Biological Activity. The Journal of Antibiotics. https://doi.org/10.7164/antibiotics.48.349
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
