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Cited by 5

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Mitochondrial/Nuclear Transfer: A Literature Review of the Ethical, Legal and Social Issues

Dupras-Leduc, Raphaëlle, Birko, Stanislav, Ravitsky, Vardit·2019·Canadian Journal of Bioethics
DOI 10.7202/1058264ar
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Abstract

Mitochondrial/nuclear transfer (M/NT) to avoid the transmission of serious mitochondrial disease raises complex and challenging ethical, legal and social issues (ELSI). In February 2015, the United Kingdom became the first country in the world to legalize M/NT, making the heated debate surrounding this technology even more relevant. This critical interpretive review identified 95 relevant papers discussing the ELSI of M/NT, including original research articles, government-commissioned reports, editorials, letters to editors and research news. The review presents and synthesizes the arguments present in the literature in relation to the most commonly raised themes: terminology; identity, relationships and parenthood; potential harm; reproductive autonomy; available alternatives; consent; impact on specific interest groups; resources; “slippery slope”; creation, use and destruction of human embryos; and beneficence. The review concludes by identifying those ELSI that are specific to M/NT and by calling for follow-up longitudinal clinical and psychosocial research in order to equip future ELSI debate with empirical evidence.

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Figure 1 Paper Selection ProcessCC-BY · From the PDF
Figure 2 Evolution of Terminology Use in the Scientific Literature
Figure 2 Evolution of Terminology Use in the Scientific LiteratureCC-BY · From the PDF

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Citations

Cites

Research works printed but not linked: 72

  1. P. Amato et al. Three-parent in vitro fertilization: gene replacement for the prevention of inherited mitochondrial diseases. Fertil Steril 2014; 101(1): 31-35
  2. F. Baylis. The ethics of creating children with three genetic parents. Reprod Biomed Online 2013; 26: 531-534
  3. Human Fertilisation and Embryology Authority (HFEA). Third scientific review of the safety and efficacy of methods to avoid mitochondrial disease through assisted conception: 2014 update. 2014
  4. D.P. Wolf, N. Mitalipov & S. Mitalipov. Mitochondrial replacement therapy in reproductive medicine. Trends Mol Med 2015; 21(2): 68-76
  5. A.L. Bredenoord & P. Braude. Ethics of mitochondrial gene replacement: from bench to bedside. BMJ 2010; 341: c6021
  6. A.L. Bredenoord et al. Nuclear transfer to prevent mitochondrial DNA disorders: revisiting the debate on reproductive cloning. Reprod BioMed Online 2011; 22: 200-207
  7. R.W. Taylor & D. Turnbull. Mitochondrial DNA mutations in human disease. Nat Rev Genet 2005; 6: 389-402;
  8. A.L. Bredenoord et al. Ethics of modifying the mitochondrial genome. J Med Ethics 2011; 37: 97-100
  9. M.D. Garasic & D. Sperling. Mitochondrial replacement therapy and parenthood. Glob Bioet 2015; 26(3-4): 198-205
  10. Hens, W. Dondorp & G. De Wert. A leap of faith? An interview study with professionals on the use of mitochondrial replacement to avoid transfer of mitochondrial diseases. Hum Reprod 2015; 30(5): 1256-1262;
  11. J.Y. Nau. Transfert mitochondrial : pari génétique britannique à haut risque. Rev Med Suisse 2015; 461: 426-427.
  12. R. McDougall. Reviewing literature in bioethics research: increasing rigour in non-systematic reviews. Bioethics 2015; 29(7): 523-8
  13. V. Ravitsky, S. Birko & R. Dupras-Leduc. The "three-parent baby": A case study of how language frames the ethical debate regarding an emerging technology. Am J Bioeth 2015 ; 15(12): 57-60
  14. A.L. Bredenoord, G. Pennings & G. De Wert. Ooplasmic and nuclear transfer to prevent mitochondrial DNA disorders: conceptual and normative issues. Hum Reprod Update 2008; 14(6): 669-678
  15. M.N. Johnson. Tri-parenthood -a simply misleading term or an ethically misguided approach? Reprod Biomed Online 2013; 26: 516-519
  16. N. Darnovksy. A slippery slope to human germline modification. Nature 2013; 499: 127
  17. S.A.M. McLean. Mitochondrial DNA Transfer: Some Reflections From The United Kingdom. BiolawJournal 2015; 2: 81-88
  18. R. Briscoe. Ethical Considerations, Safety Precautions and Parenthood in Legalising Mitochondrial Donation. New Bioeth 2013; 19(1): 2-17;
  19. Nuffield Council on Bioethics (NCB). Novel techniques for the prevention of mitochondrial DNA disorders: an ethical review. 2012
  20. H.J.M. Smeets. Preventing the transmission of mitochondrial DNA disorders: Selecting the good guys or kicking out the bad guys. Reprod Biomed Online 2013; 27, 599-610
  21. I. Szebik. Response to "Germ line therapy to cure mitochondrial disease: protocol and ethics of in vitro ovum nuclear transplantation" by Donald S. Rubenstein, David C. Thomasma, Eric A. Schon, and Michael J. Zinaman. Camb Q Healthc Ethics 1999; 8: 369-374
  22. A. Wrigley, S. Wilkinson & J.B. Appleby. Mitochondrial replacement: ethics and identity. Bioethics 2015 ; 29(9): 631- 638
  23. G.N. Allahbadia. Is the world of ART ready for a ménage à trois? J Obstet Gynaecol India 2015; 65(2): 71-74
  24. J.B. Appleby. The ethical challenges of the clinical introduction of mitochondrial replacement techniques. Med Health Care and Philos 2015; 18: 501-514
  25. R. Klitzman, M. Toynbee & M.V. Sauer. Controversies concerning mitochondrial replacement therapy. Fert Steril 2015; 103(2): 344-346
  26. S. Mitalipov & D.P. Wolf. Clinical and ethical implications of mitochondrial gene transfer. Trends Endocrinol Metab 2014; 25(1): 5-7
  27. Anonymous. Ethics of mitochondrial donation. The Lancet 2012; 379: 2314
  28. A. Sutton. A case against germ-line gene therapy. Ethics Med 2013; 29(1): 17-22
  29. R.L. Fischbach, S. Benston & J.D. Loike. Creating a three-parent child: an educational paradigm for the responsible conduct of research. J Microbiol Biol Educ 2014; 15(12): 186-190
  30. P. Ball. The art of medicine: unnatural reactions. The Lancet 2014; 383: 1964-1965
  31. H.S. Liu & P.L. Chu. Three-parent embryo: The therapeutic future for inherited mitochondrial diseases. J Formos Med Assoc 2014; 114(11): 1027-1028
  32. J. Ravindra Fernando. Three's company: a constitutional analysis of prohibiting access to three-parent in vitro fertilization. Notre Dame J Law Ethics Public Policy 2015; 29: 523-548
  33. G.P.A. Bongaerts. How to prevent 'half-bastard' progeny? or An alternative for three-parent babies: Two-parent babies through transplantation of sperm mitochondria. Med Hypothesis 2006; 67: 1266-1269
  34. A.J. Paller-Rzepka. Are you my mother? Why mitochondrial DNAtransfers require states to rework traditional, two- person legal parentage frameworks. Biotechnol Law Rep 2014; 33(5): 193-206
  35. P. Cheruvu. Three-parent IVF and its effect on parental rights. Hastings Sci Tech Law J, 2014; 6(1): 73-81
  36. N. Hawkes. Intervention to prevent transmission of mitochondrial disorders should be allowed, subject to safeguards, report says. BMJ 2012; 344:e4089
  37. I. Torjesen. Government gives the go ahead for mitochondrial donation during IVF. BMJ 2014; 349: g4801
  38. S. Grauman & H. Haker. Some conceptual and ethical comments on egg cell nuclear transfer. Politics Life Sci 1998; 1: 17-19
  39. E. Callaway. Reproductive medicine: The power of three. Nature 2014; 509: 414-417
  40. J. Poulton & P. Oakeschott. Nuclear transfer to prevent maternal transmission of mitochondrial DNA disease. BMJ 2012; 345: e6651
  41. Donald S. Rubenstein, David C. Thomasma, Eric A. Schon, & Michael J. Zinaman. Germ-line therapy to cure mitochondrial disease: protocol and ethics of in vitro ovum nuclear transplantation. Camb Q Healthc Ethics 1995; 4: 316-339
  42. A.L. Bredenoord et al. Avoiding transgenerational risks of mitochondrial DNA disorders: a morally acceptable reason for sex selection? Hum Reprod 2010 ; 25(6): 1354-1360
  43. K. Reinhardt, D.K. Dowling & E.H. Morrow. Mitochondrial replacement, evolution, and the clinic. Science 2013; 341: 1345-1346
  44. D.L. Dickenson. The commercialization of human eggs in mitochondrial replacement research. The New Bioethics 2013; 19(1): 18-29
  45. J. Richardson et al. Concise reviews: assisted reproductive technologies to prevent transmission of mitochondrial dna disease. Stem Cells 2015; 33: 639-645
  46. A.L. Bredenoord & I. Hyun. The road to mitochondrial gene transfer: follow the middle lane. Mol Ther 2015; 3(6): 975-976
  47. S. Fischer. State of the art: emerging genetic technologies in reproductive medicine are rapidly making real what once was science fiction-are we ready for it?. IEEE Pulse 2015
  48. Z. Kmietowicz. UK becomes first country to allow mitochondrial donation. BMJ 2015; 350: h1103
  49. J. Wise. Mitochondrial donation could benefit 150 UK women a year, study says. BMJ 2015; 350: h536
  50. M. Herbert & D. Turnbull. Mitochondrial replacement to prevent the transmission of mitochondrial DNA disease. Embo Reports 2015; 16(5): 539-540;
  51. J.G. Armstrong. Three-parent babies: a debate of eugenics. Penn Bioeth J 2015; 10(2): 9
  52. T. Ishii. Potential impact of human mitochondrial replacement on global policy regarding germline gene modification. Reprod Biomed Online 2014; 29: 150-155
  53. M. Legge & R. Fitzgerald. Numerical identity: the creation of tri-parental embryos to correct inherited mitochondrial disease. N Z Med J 2013; 126(1385): 71-75
  54. S. Norcross. How and why mitochondrial replacement gets our vote. Reprod Biomed Online 2014; 29(2): 267-268
  55. S. Mayor. Chief medical officer advises government to allow mitochondrial replacement to prevent disease. BMJ 2013; 346: f4211
  56. G. Vogel. FDA considers trials of 'three-parent embryos'. Science 2014; 343: 827-828
  57. E.C. Hayden. Regulators weigh benefits of 'three-parent' fertilization. Nature 2013; 502: 284-285
  58. G.R. Passi. The three parent embryo. Indian Pediatr 2015; 52: 261
  59. G. Pennings. International harmonization and mitochondrial replacement. Reprod Biomed Online 2014; 29: 269
  60. J. Wise. Draft UK regulations for mitochondrial donation are published. BMJ 2014; 348: g1846
  61. F. Flinter. Concerning Tetsuya Ishii's article: Potential impact of human mitochondrial replacement on global policy regarding germline gene modification. Reprod Biomed Online 2014; 29: 270
  62. J. Wise. Mitochondrial donation is "not unsafe," review confirms. BMJ 2014; 348: g3723
  63. V. Ravitsky. Conceived and deceived: the medical interests of donor-conceived individuals. Hastings Center Report 2012; 42(1): 17-22 2017 Updated references (not included in the literature review)
  64. J. Zhang et al. Live birth derived from oocyte spindle transfer to prevent mitochondrial disease. Reprod Biomed Online 2017; 34(4): 361-368
  65. M. Alikani et al. First birth following spindle transfer for mitochondrial replacement therapy: hope and trepidation. Reprod Biomed Online 2017; 34(4): 333-336
  66. Anonymous. Baby's DNA mix revealed. Nature 2017; 544: 17-18
  67. Bredenoord, A. et al. 2011 a Ethics of modifying the mitochondrial genome Journal of medical ethics Bredenoord, A. et al. 2011 b Nuclear transfer to prevent mitochondrial DNA disorders: revisiting the debate on reproductive cloning Reproductive Biomedicine Online
  68. Cheruvu, P. 2014 Three-Parent IVF and its Effects on Parental Rights Hastings Science and Technology Law Journal
  69. Fischbach, R.L. et al. 2014 Creating a Three-Parent Child: An Educational Paradigm for the Responsible Conduct of Research Journal of Microbiology & Biology Education
  70. Sutton, A. 2013 A case against germ-line gene therapy Ethics and Medicine Szebik, I. 1999 Response to "Germ Line Therapy to Cure Mitochondrial Disease: Protocol and Ethics of In Vitro Ovum Nuclear Transplantation" by Donald S. Rubenstein, David C. Thomasma, Eric A. Schon, Michael J. Zinaman. Cambridge Quarterly Healthcare Ethics
  71. Tanaka, A.J. et al. 2013 Harnessing the Stem Cell Potential: The path to prevent mitochondrial disease Nature Medicine Winter, G.F. 2015 Mitochondrial Donation British Journal of Midwifery
  72. Armstrong, J.G. 2015 Three-Parent Babies: A Debate of Eugenics Penn Bioethics Journal

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Metadata

Authors
Dupras-Leduc, R., Birko, S., & Ravitsky, V.
Venue
Canadian Journal of Bioethics
Publisher
Consortium Erudit
Published
2019-03-27
Volume
1
Issue
2
Pages
1-17
ISSN
2561-4665
DOI
10.7202/1058264ar
Cited by
5
References
1

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