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Acute Bronchoconstriction Induced by Cotton Dust: Dose-Related Responses to Endotoxin and Other Dust Factors
Abstract
Fifty-four healthy humans, selected for their acute airway responsiveness to cotton dust, had spirometric tests immediately before and after 6 hours of exposure to card-generated cotton dust from seven different cottons (of several grades and growing regions). During exposures, we measured airborne concentrations of viable fungi and bacteria (total and gram negative), vertically elutriated gravimetric dust, and vertically elutriated endotoxin. Correlation between each of these five exposure indices and exposure-related acute changes in forced expiratory volume in 1 s showed a statistically significant relationship between all of the indices except concentration of viable fungi. Of the other four indices, endotoxin was the most highly correlated (r = -0.94; p less than 0.00001), and gravimetric dust was the least correlated (r = -0.34; p less than 0.05). These findings suggest that gram-negative endotoxin may play a major role in the acute pulmonary response to inhaled cotton dust.
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Citations
Cited by
American thoracic society statement: occupational contribution to the burden of airway disease
(2003) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.167.5.787 · Cited by 874
Respiratory Health Hazards in Agriculture
(1998) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/ajrccm.158.supplement_1.rccm1585s1 · Cited by 495
Self-citationEnvironmental and health studies of farm workers in Swedish swine confinement buildings.
Donham, K., Haglind, P., Peterson, Y., Rylander, R., & Belin, L. (1989) · Occupational and Environmental Medicine · doi:10.1136/oem.46.1.31 · Cited by 351
Bernstein, D., Castranova, V., Donaldson, K., Fubini, B., Hadley, J., Hesterberg, T., Kane, A., Lai, D., McConnell, E. E., Muhle, H., et al. (2005) · Inhalation Toxicology · doi:10.1080/08958370591001121 · Cited by 103
Metadata
- Authors
- CASTELLAN, R. M., OLENCHOCK, S. A., HANKINSON, J. L., MILLNER, P. D., COCKE, J. B., BRAGG, C. K., PERKINS, H. H., & JACOBS, R. R.
- Venue
- Annals of Internal Medicine
- Publisher
- American College of Physicians
- Published
- 1984-08-01
- Volume
- 101
- Issue
- 2
- Pages
- 157-163
- ISSN
- 0003-4819 (ISSN-L)
- 1539-3704
- OpenAlex
- W2076982781
- Cited by
- 162
- References
- 0
- FWCI
- 11.34
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Acute Bronchoconstriction Induced by Cotton Dust: Dose-Related Responses to Endotoxin and Other Dust Factors. https://app.cochat.ai/papers/10.7326/0003-4819-101-2-157
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- CASTELLAN, R. M., OLENCHOCK, S. A., HANKINSON, J. L., MILLNER, P. D., COCKE, J. B., BRAGG, C. K., PERKINS, H. H., & JACOBS, R. R. (1984). Acute Bronchoconstriction Induced by Cotton Dust: Dose-Related Responses to Endotoxin and Other Dust Factors. Annals of Internal Medicine. https://doi.org/10.7326/0003-4819-101-2-157
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
