The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
MACOP-B Chemotherapy for the Treatment of Diffuse Large-Cell Lymphoma
Abstract
Between April 1981 and May 1984, 61 patients with advanced diffuse large-cell lymphoma completed treatment with MACOP-B (methotrexate with leucovorin rescue, doxorubicin, cyclophosphamide, vincristine, prednisone, and bleomycin), an innovative pilot chemotherapy program emphasizing weekly treatment, antibiotic prophylaxis, daily corticosteroid treatments, and brief duration (12 weeks). Fifty-one patients (84%) achieved a complete response and 10 patients (16%) had a partial response. Over a median follow-up after treatment of 23 months, the actuarial overall survival for the entire group has been 76%; for complete responders the relapse-free survival has been 90%. Toxicity was modest with one treatment-related death and seven episodes of serious infection. The most frequent toxicity was mucositis. Thus, MACOP-B is an effective treatment for large-cell lymphoma that can be delivered in 12 weeks with an acceptable incidence of toxicity. This regimen can achieve results similar and possibly superior to those of other presently used regimens of longer duration.
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Citations
Cites
Nonparametric Estimation from Incomplete Observations
Kaplan, E. L., & Meier, P. (1958) · Journal of the American Statistical Association · doi:10.1080/01621459.1958.10501452 · Cited by 39,158
Cited by
Gianni, A. M., Bregni, M., Siena, S., Brambilla, C., Di Nicola, M., Lombardi, F., Gandola, L., Tarella, C., Pileri, A., Ravagnani, F., et al. (1997) · New England Journal of Medicine · doi:10.1056/nejm199705013361804 · Cited by 470
Metadata
- Authors
- KLIMO, P., & CONNORS, J. M.
- Venue
- Annals of Internal Medicine
- Publisher
- American College of Physicians
- Published
- 1985-05-01
- Volume
- 102
- Issue
- 5
- Pages
- 596-602
- ISSN
- 0003-4819 (ISSN-L)
- 1539-3704
- OpenAlex
- W2073151455
- Cited by
- 664
- References
- 1
- FWCI
- 29.10
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: MACOP-B Chemotherapy for the Treatment of Diffuse Large-Cell Lymphoma. https://app.cochat.ai/papers/10.7326/0003-4819-102-5-596
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- KLIMO, P., & CONNORS, J. M. (1985). MACOP-B Chemotherapy for the Treatment of Diffuse Large-Cell Lymphoma. Annals of Internal Medicine. https://doi.org/10.7326/0003-4819-102-5-596
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
