Cited by 373Pharmacogenetics and Drug MetabolismDrug-Induced Adverse ReactionsDrug-Induced Hepatotoxicity and Protection

The DOI matches its Crossref record; 16 of the 16 references it cites were found in a registry or an index.

Differences in Metabolism of Sulfonamides Predisposing to Idiosyncratic Toxicity

SHEAR, NEIL H., SPIELBERG, STEPHEN P., GRANT, DENIS M., TANG, BING K., KALOW, WERNER·1986·Annals of Internal Medicine

DOI 10.7326/0003-4819-105-2-179

Open this paper in CoChat — free account

Abstract

Individual differences in metabolism of the sulfonamides may predispose patients to idiosyncratic reactions. Sulfonamides are metabolized by N-acetylation (mediated by a genetically polymorphic enzyme) and oxidation to potentially toxic metabolites. We examined 6 patients who had severe reactions to sulfonamides and compared them with 20 controls. Acetylator phenotype was determined with caffeine, a safe in-vivo probe of enzyme activity. All 6 patients were slow acetylators (expected, 55%; p less than 0.05). Detoxification of oxidative metabolites was studied in vitro with a lymphocyte assay evaluating cell death from metabolites generated by a murine hepatic microsomal system. Cells from each patient showed increased toxicity from sulfonamide metabolites but not from the drugs themselves. Cells from parents of 3 patients had intermediate toxicity from sulfonamide metabolites, whereas cells from a sibling of 1 patient had a normal response. Susceptibility to sulfonamide reactions may be due to interaction of metabolic pathways, possibly under genetic control, regulating N-acetylation and specific detoxification of toxic metabolites of the drugs.

Integrity signals

Registry

Crossref · 10.7326/0003-4819-105-2-179

Cites

16 of 16 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

TheAhLocus: Genetic Regulation of the Metabolism of Carcinogens, Drugs, and Other Environmental Chemicals by Cytochrome P-450-Mediated Monooxygenase
Nebert, D. W., Jensen, N. M., & Gelboin, H. V. (1979) · Critical Reviews in Biochemistry and Molecular Biology · doi:10.3109/10409237909105427 · Cited by 314
Variability in caffeine metabolism
Grant, D. M., Tang, B. K., & KALOW, W. (1983) · Clinical Pharmacology & Therapeutics · doi:10.1038/clpt.1983.80 · Cited by 257
Self-citation
Predisposition to Phenytoin Hepatotoxicity Assessed in Vitro
Spielberg, S. P., Gordon, G., Blake, D. A., Goldstein, D. A., & Herlong, H. F. (1981) · New England Journal of Medicine · doi:10.1056/nejm198109243051302 · Cited by 233
Self-citation
A simple test for acetylator phenotype using caffeine.
Grant, D. M., Tang, B., & KALOW, W. (1984) · British Journal of Clinical Pharmacology · doi:10.1111/j.1365-2125.1984.tb02372.x · Cited by 212
Self-citation
Sulfonamide Hepatic Injury
Dujovne, C. A., Chan, C. H., & Zimmerman, H. J. (1967) · New England Journal of Medicine · doi:10.1056/nejm196710122771503 · Cited by 126
Adverse Reactions to Sulfisoxazole, Sulfamethoxazole, and Nitrofurantoin
Koch‐Weser, J. (1971) · Archives of Internal Medicine · doi:10.1001/archinte.1971.00310210075006 · Cited by 100
In vitro evaluation of a toxic metabolite of sulfadiazine
Shear, N. H., & Spielberg, S. P. (1985) · Canadian Journal of Physiology and Pharmacology · doi:10.1139/y85-225 · Cited by 88
Self-citation
Acetaminophen toxicity in human lymphocytes in vitro.
Spielberg, S. P. (1980) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(25)32074-4 · Cited by 86
Self-citation
A SPECIFIC FEBRILE REACTION TO SULFANILAMIDE
HAGEMAN, P. O. (1937) · JAMA · doi:10.1001/jama.1937.02780350010005 · Cited by 81
Metabolism of procainamide to a hydroxylamine by rat and human hepatic microsomes.
Uetrecht, J., Sweetman, B. J., Woosley, R. L., & Oates, J. A. (1984) · Drug Metabolism and Disposition · doi:10.1016/s0090-9556(25)07692-5 · Cited by 56

Show all 16 references

Research works printed but not linked: 5

BLANCHARD A, 1958, Can Med Assoc J., 79, 627
KAUPPINEN K, 1983, Semin Dermatol., 2, 227
1984, FDA Drug Bull., 14, 5
SHAPIRO S, 1983, Proceedings of the Second World Conference on Clinical Pharmacology and Therapeutics., 949
MITCHELL J, 1984, Drug Metabolism and Drug Toxicity., 301

Sorted by citations

Items 101–200 of 373

Pharmacokinetics and adverse effects of 20-mg/kg/day trimethoprim and 100-mg/kg/day sulfamethoxazole in healthy adult subjects
Stevens, R. C., Laizure, S. C., Williams, C. L., & Stein, D. S. (1991) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.35.9.1884 · Cited by 64
Role of polymorphic and monomorphic human arylamine N-acetyltransferases in determining sulfamethoxazole metabolism
Cribb, A. E., Nakamura, H., Grant, D. M., Miller, M. A., & Spielberg, S. P. (1993) · Biochemical Pharmacology · doi:10.1016/0006-2952(93)90280-a · Cited by 62
Self-citation
Drug Antigenicity, Immunogenicity, and Costimulatory Signaling: Evidence for Formation of a Functional Antigen through Immune Cell Metabolism
Elsheikh, A., Lavergne, S. N., Castrejón-Flores, J. L., Farrell, J., Wang, H., Sathish, J. G., Pichler, W. J., Park, B. K., & Naisbitt, D. J. (2010) · The Journal of Immunology · doi:10.4049/jimmunol.1000889 · Cited by 66
Sulfonamide-reactive lymphocytes detected at very low frequency in the peripheral blood of patients with drug-induced eruptions
Kalish, R. S., LaPorte, A., Wood, J. A., & Johnson, K. L. (1994) · Journal of Allergy and Clinical Immunology · doi:10.1016/0091-6749(94)90202-x · Cited by 60
Severe hepatotoxicity in a patient receiving both acetaminophen and zidovudine
Shriner, K. A., & Goetz, M. B. (1992) · The American Journal of Medicine · doi:10.1016/0002-9343(92)90687-7 · Cited by 60
Low N‐acetylating capacity in patients with Stevens‐Johnson syndrome and toxic epidermal necrolysis*
Dietrich, A., Kawakubo, Y., Rzany, B., Mockenhaupt, M., Simon, J. C., & Schöpf, E. (1995) · Experimental Dermatology · doi:10.1111/j.1600-0625.1995.tb00211.x · Cited by 60
Pharmacokinetics of trimethoprim-sulfamethoxazole in critically ill and non-critically ill AIDS patients
Chin, T. W., Vandenbroucke, A., & Fong, I. W. (1995) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.39.1.28 · Cited by 59
In Vitro Assessment of Risk
Shear, N. H., Spielberg, S. P., & MILLER, M. A. (1988) · Cited by 59
Self-citation
Plasma Cysteine Deficiency and Decreased Reduction of Nitrososulfamethoxazole with HIV Infection
Naisbitt, D. J., Vilar, F. J., Stalford, A. C., Wilkins, E. G. L., Pirmohamed, M., & Park, B. K. (2000) · AIDS Research and Human Retroviruses · doi:10.1089/088922200750054657 · Cited by 59
A retrospective evaluation of adverse reactions to trimethoprim‐sulphonamide combinations in dogs and cats
Noli, C., Koeman, J. P., & Willemse, T. (1995) · Veterinary Quarterly · doi:10.1080/01652176.1995.9694550 · Cited by 58
Intrahepatic Cholestasis and Phospholipidosis Associated With the Use of Trimethoprim–Sulfamethoxazole
Muñoz, S. J., Martinez-Hernandez, A., & Maddrey, W. C. (1990) · Hepatology · doi:10.1002/hep.1840120223 · Cited by 58
ANTICONVULSANT HYPERSENSITIVITY SYNDROME
Morkunas, A. R., & Miller, M. B. (1997) · Critical Care Clinics · doi:10.1016/s0749-0704(05)70366-3 · Cited by 58
8 Acute and chronic drug-induced hepatitis
Pessayre, D., & Larrey, D. G. (1988) · Baillière s Clinical Gastroenterology · doi:10.1016/0950-3528(88)90009-7 · Cited by 58
Treatment Strategies in Toxic Epidermal Necrolysis Syndrome: Where Are We At?
Abood, G. J., Nickoloff, B. J., & Gamelli, R. L. (2008) · Journal of Burn Care & Research · doi:10.1097/bcr.0b013e31815f3658 · Cited by 56
Acetylator phenotype and genotype in patients infected with HIV: discordance between methods for phenotype determination and genotype
O’Neil, W. M., Drobitch, R. K., MacArthur, R. D., Farrough, M. J., Doll, M. A., Fretland, A. J., Hein, D. W., Crane, L. R., & Svensson, C. K. (2000) · Pharmacogenetics · doi:10.1097/00008571-200003000-00009 · Cited by 56
A Randomized Trial of N-Acetylcysteine for Prevention of Trimethoprim-Sulfamethoxazole Hypersensitivity Reactions in Pneumocystis carinii Pneumonia Prophylaxis (CTN 057)
Walmsley, S. L., Khorasheh, S., Singer, J., & Djurdjev, O. (1998) · Journal of Acquired Immune Deficiency Syndromes & Human Retrovirology · doi:10.1097/00042560-199812150-00009 · Cited by 54
Diagnosing Cutaneous Adverse Reactions to Drugs
Shear, N. H. (1990) · Archives of Dermatology · doi:10.1001/archderm.126.1.94 · Cited by 54
Self-citation
Low drug attributability of aplastic anemia in Thailand. The Aplastic Anemia Study Group.
Issaragrisil, S., Kaufman, D. W., Anderson, T. E., Chansung, K., Thamprasit, T., Sirijirachai, J., Piankijagum, A., Porapakkham, Y., Vannasaeng, S., Leaverton, P. E., et al. (1997) · PubMed · doi:10.1182/blood.v89.11.4034 · Cited by 53
Polymorphisms of NAT2 in relation to sulphasalazine-induced agranulocytosis
Wadelius, M., Stjernberg, E., Wiholm, B., & Rane, A. (2000) · Pharmacogenetics · doi:10.1097/00008571-200002000-00005 · Cited by 53
Characterization of the Formation and Localization of Sulfamethoxazole and Dapsone-Associated Drug-Protein Adducts in Human Epidermal Keratinocytes
Roychowdhury, S., Vyas, P. M., Reilly, T. P., Gaspari, A. A., & Svensson, C. K. (2005) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.105.086009 · Cited by 56
Drug‐Induced Liver Injury
Pessayre, D., & Larrey, D. G. (2007) · Wiley eBooks · doi:10.1002/9780470691861.ch14a · Cited by 54
Novel Treatments for Drug-Induced Toxic Epidermal Necrolysis (Lyell’s Syndrome)
Paquet, P., Pierard, G., & Quatresooz, P. (2005) · International Archives of Allergy and Immunology · doi:10.1159/000083947 · Cited by 52
Formation and elimination of sulphamethoxazole hydroxylamine after oral administration of sulphamethoxazole.
van der Ven, A., Mantel, M., Vree, T. B., Koopmans, P., & van der Meer, J. (1994) · British Journal of Clinical Pharmacology · doi:10.1111/j.1365-2125.1994.tb04339.x · Cited by 52
Adverse Reactions to Trimethoprim/Sulfamethoxazole in AIDS
Floris-Moore, M., Amodio-Groton, M. I., & Catalano, M. T. (2003) · Annals of Pharmacotherapy · doi:10.1345/aph.1d179 · Cited by 51
The Role of Reactive Drug Metabolites in Immune-Mediated Adverse Drug Reactions
Hess, D. A., & Rieder, M. J. (1997) · Annals of Pharmacotherapy · doi:10.1177/106002809703101116 · Cited by 50
Six-year Retrospective Review of Drug Reaction with Eosinophilia and Systemic Symptoms
Wongkitisophon, P., Vachiramon, V., Chanprapaph, K., & Rattanakaemakorn, P. (2012) · Acta Dermato Venereologica · doi:10.2340/00015555-1222 · Cited by 48
Drug Rashes
Chosidow, O. (1994) · Archives of Dermatology · doi:10.1001/archderm.1994.01690050095017 · Cited by 48
Desensitization for Hypersensitivity Reactions to Medications
Sancho‐Serra, M. D. C., Breslow, R. G., Sloane, D., & Castells, M. (2012) · Chemical immunology/Fortschritte der Allergielehre/Progress in allergy/Chemical immunology and allergy · doi:10.1159/000335637 · Cited by 47
Adverse drug reactions to treatments for ocular toxoplasmosis: A retrospective chart review
Iaccheri, B., Fiore, T., Papadaki, T., Androudi, S. N., Janjua, S., Bhaila, I., & Foster, C. S. (2008) · Clinical Therapeutics · doi:10.1016/j.clinthera.2008.10.021 · Cited by 46
Association of Hepatic Necrosis With Trimethoprim Sulfonamide Administration in 4 Dogs
Twedt, D. C., Diehl, K. J., Lappin, M. R., & Getzy, D. M. (1997) · Journal of Veterinary Internal Medicine · doi:10.1111/j.1939-1676.1997.tb00068.x · Cited by 46
Sulfonamide-induced reactions in desensitized patients with AIDS—The role of covalent protein haptenation by sulfamethoxazole☆☆☆★★★
Gruchalla, R. S., Pesenko, R. D., Thinh, T. H., & Skiest, D. J. (1998) · Journal of Allergy and Clinical Immunology · doi:10.1016/s0091-6749(98)70250-7 · Cited by 46
Patients with Delayed-Onset Sulfonamide Hypersensitivity Reactions Have Antibodies Recognizing Endoplasmic Reticulum Luminal Proteins
Cribb, A. E., Pohl, L. R., Spielberg, S. P., & Leeder, J. S. (1997) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(24)36874-0 · Cited by 46
Self-citation
Sulfasalazine in the rheumatic disease
Pinals, R. S. (1988) · Seminars in Arthritis and Rheumatism · doi:10.1016/0049-0172(88)90010-8 · Cited by 46
Physiopathology and treatment of severe drug eruptions
Bachot, N., & Roujeau, J. (2001) · Current Opinion in Allergy and Clinical Immunology · doi:10.1097/00130832-200108000-00003 · Cited by 45
Serum sickness—like reaction to cefaclor: Lack of in vitro cross-reactivity with loracarbef*
Kearns, G. L., Wheeler, J. G., Rieder, M. J., & Reid, J. (1998) · Clinical Pharmacology & Therapeutics · doi:10.1016/s0009-9236(98)90093-5 · Cited by 45
Genetic predisposition to drug hepatotoxicity: Role in hepatitis caused by amineptine, a tricyclic antidepressant
Larrey, D. G., Berson, A., Habersetzer, F., Tinel, M., Castot, A., Babany, G., Lettéron, P., Fréneaux, E., Loeper, J., Dansette, P. M., et al. (1989) · Hepatology · doi:10.1002/hep.1840100208 · Cited by 45
Mechanisms of drug reactions: The metabolic track
Shapiro, L. E., & Shear, N. H. (1996) · Seminars in Cutaneous Medicine and Surgery · doi:10.1016/s1085-5629(96)80034-4 · Cited by 45
Self-citation
Drug reaction with eosinophilia and systemic symptoms: manifestations, treatment, and outcome in 17 patients
Sultan, S. J., Sameem, F., & Ashraf, M. (2014) · International Journal of Dermatology · doi:10.1111/ijd.12331 · Cited by 44
Human N-acetylation genotype determination with urinary caffeine metabolites
Kilbane, A. J., Silbart, L. K., Manis, M. O., Beitins, I. Z., & Weber, W. W. (1990) · Clinical Pharmacology & Therapeutics · doi:10.1038/clpt.1990.59 · Cited by 43
Multiple drug allergy syndrome: A distinct clinical entity
Asero, R. (2001) · Current Allergy and Asthma Reports · doi:10.1007/s11882-001-0092-5 · Cited by 43
Metoprolol-lnduced Hepatitis: Rechallenge and Drug Oxidation Phenotyping
Larrey, D. G., HENRION, J., HELLER, F., BABANY, G., Degott, C., Pessayre, D., & BENHAMOU, J.-P. (1988) · Annals of Internal Medicine · doi:10.7326/0003-4819-108-1-67 · Cited by 43
Computer‐Assisted Evaluation of Adverse Events Using a Bayesian Approach
Lanctôt, K. L., & Naranjo, C. A. (1994) · The Journal of Clinical Pharmacology · doi:10.1002/j.1552-4604.1994.tb03978.x · Cited by 43
Polymorphism in glutamate cysteine ligase catalytic subunit (GCLC) is associated with sulfamethoxazole-induced hypersensitivity in HIV/AIDS patients
Wang, D., Curtis, A., Papp, A. C., Koletar, S. L., & Para, M. F. (2012) · BMC Medical Genomics · doi:10.1186/1755-8794-5-32 · Cited by 46
Novel non-labile covalent binding of sulfamethoxazole reactive metabolites to cultured human lymphoid cells
Summan, M., & Cribb, A. E. (2002) · Chemico-Biological Interactions · doi:10.1016/s0009-2797(02)00060-1 · Cited by 43
Time-course of toxicity of reactive sulfonamide metabolites
Rieder, M. J., Krause, R. S., & Bird, I. A. (1995) · Toxicology · doi:10.1016/0300-483x(94)02900-f · Cited by 42
Toxic epidermal necrolysis
Hoetzenecker, W., Mehra, T., Saulīte, I., Glatz, M., Schmid‐Grendelmeier, P., Guenova, E., Cozzio, A., & French, L. E. (2016) · F1000Research · doi:10.12688/f1000research.7574.1 · Cited by 41
An in vitro investigation of predisposition to sulphonamide idiosyncratic toxicity in dogs
Cribb, A. E., & Spielberg, S. P. (1990) · Veterinary Research Communications · doi:10.1007/bf00347744 · Cited by 41
Self-citation
Monitoring Adverse Drug Reactions to Sulfonamide Antibiotics in Human Immunodeficiency Virus–Infected Individuals
Neuman, M. G., Malkiewicz, I. M., Phillips, E. J., Rachlis, A., Ong, D., Yeung, E., & Shear, N. H. (2002) · Therapeutic Drug Monitoring · doi:10.1097/00007691-200212000-00008 · Cited by 40
Self-citation
Inhibition of sulfamethoxazole hydroxylamine formation by fluconazole in human liver microsomes and healthy volunteers*
Mitra, A., Thummel, K. E., Kalhorn, T. F., Kharasch, E. D., Unadkat, J. D., & Slattery, J. T. (1996) · Clinical Pharmacology & Therapeutics · doi:10.1016/s0009-9236(96)80011-7 · Cited by 40
Thiacetazone—avoid like poison or use with care?
Nunn, P. P., Porter, J., & Winstanley, P. (1993) · Transactions of the Royal Society of Tropical Medicine and Hygiene · doi:10.1016/0035-9203(93)90096-9 · Cited by 40
Immune response to sulfamethoxazole in patients with AIDS
Daftarian, M. P., Filion, L. G., Cameron, D. W., Conway, B. R., Roy, R., Tropper, F. D., & Díaz‐Mitoma, F. (1995) · Clinical and Diagnostic Laboratory Immunology · doi:10.1128/cdli.2.2.199-204.1995 · Cited by 40
In Vitro Testing for the Diagnosis of Anticonvulsant Hypersensitivity Syndrome
Elzagallaai, A. A., Knowles, S. R., Rieder, M. J., Bend, J. R., Shear, N. H., & Koren, G. (2009) · Molecular Diagnosis & Therapy · doi:10.1007/bf03256336 · Cited by 39
Self-citation
Toxic epidermal necrolysis: Revisiting the tentative link between early apoptosis and late necrosis (Review)
Paquet, P., & Pierard, G. (2007) · International Journal of Molecular Medicine · doi:10.3892/ijmm.19.1.3 · Cited by 39
Severe DRESS Syndrome Managed With Therapeutic Plasma Exchange
Alexander, T., Edward Iglesia, B. A., Park, Y., Duncan, D. R., Peden, D. B., Sheikh, S. Z., & Ferris, M. (2013) · PEDIATRICS · doi:10.1542/peds.2012-2117 · Cited by 38
Sulfonamide Hypersensitivity
Chow, T. G., & Khan, D. A. (2021) · Clinical Reviews in Allergy & Immunology · doi:10.1007/s12016-021-08872-3 · Cited by 38
Mechanisms of drug eruptions: Part I
BREATHNACH, S. M. (1995) · Australasian Journal of Dermatology · doi:10.1111/j.1440-0960.1995.tb00953.x · Cited by 38
Drug-induced liver disease
Roberts, E. A. (2014) · Cambridge University Press eBooks · doi:10.1017/cbo9781139012102.023 · Cited by 37
N‐acetylation genotype and risk of severe reactions to sulphonamides in AIDS patients [letter]
Deloménie, C., Grant, D., Mathelier‐Fusade, P., Jacomet, C., Leynadier, F., Jacqz-Aigrain, É., Rozenbaum, W., Krishnamoorthy, R., & Dupret, J. (1994) · British Journal of Clinical Pharmacology · doi:10.1111/j.1365-2125.1994.tb04401.x · Cited by 37
Self-citation
Acetylator Phenotype and Genotype in HIV‐Infected Patients with and without Sulfonamide Hypersensitivity
O’Neil, W. M., MacArthur, R. D., Farrough, M. J., Doll, M. A., Fretland, A. J., Hein, D. W., Crane, L. R., & Svensson, C. K. (2002) · The Journal of Clinical Pharmacology · doi:10.1177/00970002042006004 · Cited by 37
Drug allergy diagnosis in humans: possibilities and pitfalls
Choquet‐Kastylevsky, G., Vial, T., & Descotes, J. (2001) · Toxicology · doi:10.1016/s0300-483x(00)00396-6 · Cited by 36
Relation of amiodarone hepatic and pulmonary toxicity to serum drug concentrations and superoxide dismutase activity
Pollak, P. T., Sharma, A. D., & Carruthers, S. G. (1990) · The American Journal of Cardiology · doi:10.1016/0002-9149(90)90971-3 · Cited by 36
Toxic epidermal necrolysis (TEN) Lyell's syndrome
Sehgal, V. N., & Srivastava, G. (2005) · Journal of Dermatological Treatment · doi:10.1080/09546630500375684 · Cited by 35
IN VIVO AND IN VITRO TESTING FOR ADVERSE DRUG REACTIONS
Rieder, M. J. (1997) · Pediatric Clinics of North America · doi:10.1016/s0031-3955(05)70465-x · Cited by 35
Suppression of T-lymphocyte proliferation by sulphonamide hydroxylamines
Rieder, M. J., Sisson, E., Bird, I. A., & Almawi, W. Y. (1992) · International Journal of Immunopharmacology · doi:10.1016/0192-0561(92)90052-m · Cited by 34
Bosentan therapy for pulmonary arterial hypertension
Cohen, H., Chahine, C., Hui, A., & Mukherji, R. (2004) · American Journal of Health-System Pharmacy · doi:10.1093/ajhp/61.11.1107 · Cited by 33
Which intercurrent infections are associated with maculopapular cutaneous drug reactions? A case‐control study
Cohen, A. D., Friger, M. D., Sarov, B., & Halevy, S. (2001) · International Journal of Dermatology · doi:10.1046/j.1365-4362.2001.00081.x · Cited by 33
Roles of endogenous ascorbate and glutathione in the cellular reduction and cytotoxicity of sulfamethoxazole-nitroso
Lavergne, S. N., Kurian, J. R., Bajad, S. U., Maki, J. E., Yoder, A. R., Guzinski, M. V., Graziano, F. M., & Trepanier, L. A. (2006) · Toxicology · doi:10.1016/j.tox.2006.01.018 · Cited by 33
Mechanistic perspectives on sulfonamide-induced cutaneous drug reactions
Reilly, T. P., & Ju, C. (2002) · Current Opinion in Allergy and Clinical Immunology · doi:10.1097/00130832-200208000-00004 · Cited by 31
Plasma Ascorbate Deficiency Is Associated With Impaired Reduction of Sulfamethoxazole-Nitroso in HIV Infection
Trepanier, L. A., Yoder, A. R., Bajad, S. U., Beckwith, M. D., Bellehumeur, J. L., & Graziano, F. M. (2004) · JAIDS Journal of Acquired Immune Deficiency Syndromes · doi:10.1097/00126334-200408150-00007 · Cited by 30
Increased Adverse Drug Reactions to Antimicrobials and Anticonvulsants in Patients with HIV Infection
Lin, D., TUCKER, M., & Rieder, M. J. (2006) · Annals of Pharmacotherapy · doi:10.1345/aph.1g525 · Cited by 31
Fluorescence-based viability assay for studies of reactive drug intermediates
Leeder, J. S., Dosch, H., Harper, P. A., Lam, P., & Spielberg, S. P. (1989) · Analytical Biochemistry · doi:10.1016/0003-2697(89)90067-5 · Cited by 31
Self-citation
Adverse reactions to co-trimoxazole in HIV infection: A reappraisal of the glutathione-hydroxylamine hypothesis
van der Ven, A. J. A. M., Vree, T. B., Koopmans, P. P., & van der Meer, J. W. M. (1996) · Journal of Antimicrobial Chemotherapy · doi:10.1093/jac/37.suppl_b.55 · Cited by 31
Drug Reactions
BREATHNACH, S. M. (2010) · Wiley eBooks · doi:10.1002/9781444317633.ch75 · Cited by 31
Drug monitoring during the treatment of AIDS‐associated Pneumocystis carinii pneumonia with trimethoprim‐sulfamethoxazole
Klinker, H., Langmann, P., Zilly, M., & Richter, E. (1998) · Journal of Clinical Pharmacy and Therapeutics · doi:10.1046/j.1365-2710.1998.00152.x · Cited by 29
DIAGNOSTIC TESTING FOR DRUG HYPERSENSITIVITY
Weiss, M. E., & Adkinson, N. F. (1998) · Immunology and Allergy Clinics of North America · doi:10.1016/s0889-8561(05)70035-7 · Cited by 27
Bioactivation of dapsone to a cytotoxic metabolite: in vitro use of a novel two compartment system which contains human tissues.
Riley, R., Roberts, P., Coleman, M. D., Kitteringham, N. R., & Park, B. K. (1990) · British Journal of Clinical Pharmacology · doi:10.1111/j.1365-2125.1990.tb03793.x · Cited by 29
In-Vitro Approaches to Predict and Study T-Cell Mediated Hypersensitivity to Drugs
Hammond, S., Thomson, P., Meng, X., & Naisbitt, D. J. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.630530 · Cited by 30
Drug-induced toxic epidermal necrolysis. II. Current aspects
Roujeau, J. (1993) · Clinics in Dermatology · doi:10.1016/0738-081x(93)90156-7 · Cited by 28
Evaluation of polymorphisms in the sulfonamide detoxification genes NAT2, CYB5A, and CYB5R3 in patients with sulfonamide hypersensitivity
Sacco, J., Abouraya, M., Motsinger‐Reif, A. A., Yale, S. H., McCarty, C. A., & Trepanier, L. A. (2012) · Pharmacogenetics and Genomics · doi:10.1097/fpc.0b013e328357a735 · Cited by 29
Cellular toxicity of sulfamethoxazole reactive metabolites—I
Leeder, J. S., Dosch, H.-M., & Spielberg, S. P. (1991) · Biochemical Pharmacology · doi:10.1016/0006-2952(91)90629-j · Cited by 27
Self-citation
Phenobarbital hepatotoxicity in an 8-month-old infant
Roberts, E. A., Spielberg, S. P., Goldbach, M., & Phillips, M. J. (1990) · Journal of Hepatology · doi:10.1016/0168-8278(90)90058-y · Cited by 27
Self-citation
Toxic Epidermal Necrolysis in Children: Medical, Surgical, and Ophthalmologic Considerations
Goyal, S., Gupta, P., Ryan, C. M., Kazlas, M. A., Noviski, N., & Sheridan, R. L. (2009) · Journal of Burn Care & Research · doi:10.1097/bcr.0b013e3181a28c82 · Cited by 26
Sulfasalazine‐Induced Agranulocytosis Is Associated With the Human Leukocyte Antigen Locus
Wadelius, M., Eriksson, N., Kreutz, R. H., Bondon‐Guitton, E., Ibáñez, L., Carvajal, A., Lucena, M. I., Ponce, E. S., Molokhia, M., Martin, J. J., et al. (2017) · Clinical Pharmacology & Therapeutics · doi:10.1002/cpt.805 · Cited by 27
Definition of Haptens Derived from Sulfamethoxazole: In Vitro and in Vivo
Tailor, A., Waddington, J. C., Hamlett, J., Maggs, J., Kafu, L., Farrell, J., Dear, G. J., Whitaker, P., Naisbitt, D. J., Park, K., et al. (2019) · Chemical Research in Toxicology · doi:10.1021/acs.chemrestox.9b00282 · Cited by 26
Ethacrynic Acid and the Sulfa-Sensitive Patient
Wall, G. C., Bigner, D. R., & Craig, S. R. (2003) · Archives of Internal Medicine · doi:10.1001/archinte.163.1.116 · Cited by 26
NADH-dependent reduction of sulphamethoxazole hydroxylamine in dog and human liver microsomes
Trepanier, L. A., & Miller, J. L. (2000) · Xenobiotica · doi:10.1080/00498250010013908 · Cited by 26
Erythema multiforme
Brice, S. L., Huff, J. C., & Weston, W. L. (1990) · Current Problems in Dermatology · doi:10.1016/s1040-0486(06)80004-9 · Cited by 26
Sequential assessment of an antidrug antibody response in a patient with a systemic delayed-onset sulphonamide hypersensitivity syndrome reaction
Bedard, K., Smith, S., & Cribb, A. E. (2000) · British Journal of Dermatology · doi:10.1046/j.1365-2133.2000.03293.x · Cited by 26
Oral trimethoprim/sulfamethoxazole in the treatment of acne vulgaris.
Bhambri, S., Rosso, J. Q. D., & Desai, A. (2007) · PubMed · Cited by 25
Leflunomide-induced DRESS syndrome with renal involvement and vasculitis
Pinto, B., Dhir, V., Krishnan, S., & Nada, R. (2012) · Clinical Rheumatology · doi:10.1007/s10067-012-2152-8 · Cited by 25
Gaining more insight into the pathomechanisms of thiol-induced acantholysis
Wolf, R., & Ruocco, V. (1997) · Medical Hypotheses · doi:10.1016/s0306-9877(97)90277-2 · Cited by 25
Delayed hypersensitivity reactions to sulphonamides: syndromes, pathogenesis and management
Trepanier, L. A. (1999) · Veterinary Dermatology · doi:10.1046/j.1365-3164.1999.00173.x · Cited by 25
NEW ADVANCES IN SEVERE ADVERSE DRUG RESCTIONS
Revuz, J. E. (2001) · Dermatologic Clinics · doi:10.1016/s0733-8635(05)70309-0 · Cited by 25
Cutaneous Adverse Events Caused by Sulfonamide-Containing Drugs: Reality or Perception?
Shah, F., & Bell, I. M. (2020) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.9b01932 · Cited by 25
Co-trimoxazole-induced hepatic injury — an analysis of cases with hypersensitivity-like reactions
Berg, P. A., & Daniel, P. (1987) · Infection · doi:10.1007/bf01643200 · Cited by 24
Allergic Cutaneous Reactions to Drugs
Bigby, M. E., Stern, R. S., & Arndt, K. A. (1989) · Primary Care Clinics in Office Practice · doi:10.1016/s0095-4543(21)01338-5 · Cited by 24
Glutathione-S-Transferase Pi Expression in Toxic Epidermal Necrolysis: A Marker of Putative Oxidative Stress in Keratinocytes
Paquet, P., & Pierard, G. (2006) · Skin Pharmacology and Physiology · doi:10.1159/000097652 · Cited by 23
Immune mediation of hypersensitivity adverse drug reactions: implications for therapy
Rieder, M. J. (2009) · Expert Opinion on Drug Safety · doi:10.1517/14740330902933736 · Cited by 23
Cellular toxicity of sulfamethoxazole reactive metabolites—II
Leeder, J. S., NAKHOODA, A. F., Spielberg, S. P., & Dosch, H.-M. (1991) · Biochemical Pharmacology · doi:10.1016/0006-2952(91)90630-n · Cited by 23
Self-citation
Hypersensitivity Reactions to Non-Beta-Lactam Antibiotics
Tilles, S. A., & Slatore, C. G. (2003) · Clinical Reviews in Allergy & Immunology · doi:10.1385/criai:24:3:221 · Cited by 23

Authors: SHEAR, N. H., SPIELBERG, S. P., GRANT, D. M., TANG, B. K., & KALOW, W.
Affiliations: Toronto, Ontario Canada
Corresponding author: SHEAR, NEIL H.
ORCID: SHEAR, NEIL H.
Venue: Annals of Internal Medicine
Publisher: American College of Physicians
Published: 1986-08-01
Volume: 105
Issue: 2
Pages: 179-184
ISSN: 0003-4819 (ISSN-L)
1539-3704
DOI: 10.7326/0003-4819-105-2-179
OpenAlex: W2058391540
Cited by: 373
References: 16
Citations by year: 2026: 4 · 2025: 2 · 2024: 1 · 2023: 1 · 2022: 5 · 2021: 6 · 2020: 4 · 2019: 5 · 2018: 6 · 2017: 4 · 2016: 7 · 2015: 8 · 2014: 6 · 2013: 3 · 2012: 15
FWCI: 9.43
Type: journal article
Language: en
Open access: closed
Licence: www.acpjournals.org/journal/aim/text-and-data-mining (tdm)
Locations: Annals of Internal Medicine (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmacology › Pharmacogenetics and Drug Metabolism
Health Sciences › Medicine › Pharmacology (medical) › Drug-Induced Adverse Reactions
Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmacology › Drug-Induced Hepatotoxicity and Protection
Keywords: sulfonamides, idiosyncratic drug toxicity, N-acetylation, acetylator phenotype, slow acetylators, detoxification, genetic polymorphism, hepatic microsomal enzymes, lymphocyte cytotoxicity, familial predisposition
MeSH terms: Acetylation, Adult, Animals, Cell Survival, Child, Child, Preschool, Female, Humans, Infant, Lymphocytes, Male, Microsomes, Liver, Phenotype, Sulfonamides, Mice, In Vitro Techniques

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Differences in Metabolism of Sulfonamides Predisposing to Idiosyncratic Toxicity

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks