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Hepatocellular Carcinoma
Abstract
Hepatocellular carcinoma is the most frequent cancer worldwide, responsible for approximately 1,000,000 deaths annually, most of them in the Far East and in sub-Saharan Africa. It usually presents at an advanced stage and has a poor prognosis. There is evidence of an etiologic role for hepatitis B virus infection in the etiology of hepatocellular carcinoma. Carriers of the virus are 94 times more at risk for hepatocellular carcinoma than noncarriers. In many cases hepatitis B virus DNA is integrated within the cellular genome of the tumor. Programs have been established to detect hepatocellular carcinoma at an early stage; persons at high risk are regularly screened by measurement of serum alpha-fetoprotein levels and ultrasound examination of the liver. Surgical resection offers the only hope of cure at present, as chemotherapy, radiotherapy, and immunotherapy have not shown promise. Ideally, surgery should be done on small asymptomatic tumors.
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Citations
Cited by
Pelletier, G., Roche, A., Ink, O., Anciaux, M. L., Derhy, S., Rougier, P., Lenoir, C., Attali, P., & Etienne, J.-P. (1990) · Journal of Hepatology · doi:10.1016/0168-8278(90)90110-d · Cited by 417
Trevisani, F. (2002) · The American Journal of Gastroenterology · doi:10.1016/s0002-9270(01)04119-3 · Cited by 313
Strigari, L., Sciuto, R., Rea, S., Carpanese, L., Pizzi, G., Soriani, A., Iaccarino, G., Benassi, M., Ettorre, G. M., & Maini, C. L. (2010) · Journal of Nuclear Medicine · doi:10.2967/jnumed.110.075861 · Cited by 239
Loomba, R., Yang, H.-I., Su, J., Brenner, D., Barrett-Connor, E., Iloeje, U., & Chen, C.-J. (2013) · American Journal of Epidemiology · doi:10.1093/aje/kws252 · Cited by 221
Hepatocellular carcinoma in primary biliary cirrhosis and its impact on outcomes
Jones, D. E., Metcalf, J. V., Collier, J. D., Bassendine, M. F., & James, O. F. (1997) · Hepatology · doi:10.1002/hep.510260508 · Cited by 161
Metadata
- Authors
- DI BISCEGLIE, A. M., RUSTGI, V. K., HOOFNAGLE, J. H., DUSHEIKO, G. M., & LOTZE, M. T.
- Venue
- Annals of Internal Medicine
- Publisher
- American College of Physicians
- Published
- 1988-03-01
- Volume
- 108
- Issue
- 3
- Pages
- 390-401
- ISSN
- 0003-4819 (ISSN-L)
- 1539-3704
- OpenAlex
- W109080479
- Cited by
- 454
- References
- 0
- FWCI
- 14.41
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Hepatocellular Carcinoma. https://app.cochat.ai/papers/10.7326/0003-4819-108-3-390
- The paper
- DI BISCEGLIE, A. M., RUSTGI, V. K., HOOFNAGLE, J. H., DUSHEIKO, G. M., & LOTZE, M. T. (1988). Hepatocellular Carcinoma. Annals of Internal Medicine. https://doi.org/10.7326/0003-4819-108-3-390
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
