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Hepatitis after Germander (Teucrium chamaedrys) Administration: Another Instance of Herbal Medicine Hepatotoxicity
Abstract
OBJECTIVE: To show that germander (Teucrium chamaedrys), an herbal medicine used to facilitate weight loss, may be hepatotoxic and to delineate the nature of the injury. DESIGN: Retrospective study. SETTING: Liver units of several centers in the French Network of Pharmacovigilance. PATIENTS: Seven patients who developed hepatitis after germander administration and who had no other cause of liver injury. MEASUREMENTS: Clinical examination, liver function tests, various serologic tests, ultrasonography, and histologic study. RESULTS: Hepatitis characterized by jaundice and a marked increase in serum aminotransferase levels occurred 3 to 18 weeks after germander administration. Liver biopsy specimens in three patients showed hepatocyte necrosis. After discontinuing treatment with germander, jaundice disappeared within 8 weeks and recovery was complete in 1.5 to 6 months. In three cases, germander readministration was followed by the prompt recurrence of hepatitis. CONCLUSION: Germander may be hepatotoxic, which supports the view that herbal medicines are not always as safe as generally assumed.
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Citations
Cited by
Lee, W. M. (2003) · New England Journal of Medicine · doi:10.1056/nejmra021844 · Cited by 1,594
Mack, C. L., Adams, D., Assis, D. N., Kerkar, N., Manns, M. P., Mayo, M. J., Vierling, J. M., Alsawas, M., Murad, M. H., & Czaja, A. J. (2020) · Hepatology · doi:10.1002/hep.31065 · Cited by 983
Andrade, R. J., Chalasani, N., Björnsson, E. S., Suzuki, A., Kullak-Ublick, G. A., Watkins, P. B., Devarbhavi, H., Merz, M., Lucena, M. I., Kaplowitz, N., et al. (2019) · Nature Reviews Disease Primers · doi:10.1038/s41572-019-0105-0 · Cited by 924
Herbal medicine in the treatment of liver diseases
Stickel, F., & Schuppan, D. (2007) · Digestive and Liver Disease · doi:10.1016/j.dld.2006.11.004 · Cited by 364
Should we be concerned about herbal remedies
Elvin-Lewis, M. (2001) · Journal of Ethnopharmacology · doi:10.1016/s0378-8741(00)00394-9 · Cited by 293
Metadata
- Authors
- Larrey, D., Vial, T., Pauwels, A., Castot, A., Biour, M., David, M., & Michel, H.
- Venue
- Annals of Internal Medicine
- Publisher
- American College of Physicians
- Published
- 1992-07-15
- Volume
- 117
- Issue
- 2
- Pages
- 129-132
- ISSN
- 0003-4819 (ISSN-L)
- 1539-3704
- OpenAlex
- W2076520163
- Cited by
- 271
- References
- 0
- FWCI
- 8.71
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Hepatitis after Germander (Teucrium chamaedrys) Administration: Another Instance of Herbal Medicine Hepatotoxicity. https://app.cochat.ai/papers/10.7326/0003-4819-117-2-129
- The paper
- Larrey, D., Vial, T., Pauwels, A., Castot, A., Biour, M., David, M., & Michel, H. (1992). Hepatitis after Germander (Teucrium chamaedrys) Administration: Another Instance of Herbal Medicine Hepatotoxicity. Annals of Internal Medicine. https://doi.org/10.7326/0003-4819-117-2-129
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