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Cited by 486Trauma, Hemostasis, Coagulopathy, ResuscitationSepsis Diagnosis and TreatmentHemodynamic Monitoring and Therapy

The DOI matches its Crossref record; 110 of the 112 references it cites were found in a registry or an index.

Patient Survival after Human Albumin Administration: A Meta-Analysis of Randomized, Controlled Trials

Wilkes, Mahlon M., Navickis, Roberta J.·2001·Annals of Internal Medicine
DOI 10.7326/0003-4819-135-3-200108070-00007
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Abstract

PURPOSE: To test the hypothesis that albumin administration is not associated with excess mortality. DATA SOURCES: Computer searches of the MEDLINE and EMBASE databases, the Cochrane Library, and Internet documents; hand searching of medical journals; inquiries to investigators and medical directors; and review of reference lists. STUDY SELECTION: Randomized, controlled trials comparing albumin therapy with crystalloid therapy, no albumin, or lower doses of albumin. DATA EXTRACTION: Two investigators independently extracted data. The primary end point was relative risk for death. Criteria used to assess methodologic quality were blinding, method of allocation concealment, presence of mortality as a study end point, and crossover. Small-trial bias was also investigated. DATA SYNTHESIS: Fifty-five trials involving surgery or trauma, burns, hypoalbuminemia, high-risk neonates, ascites, and other indications were included. Albumin administration did not significantly affect mortality in any category of indications. For all trials, the relative risk for death was 1.11 (95% CI, 0.95 to 1.28). Relative risk was lower among trials with blinding (0.73 [CI, 0.48 to 1.12]; n = 7), mortality as an end point (1.00 [CI, 0.84 to 1.18]; n = 17), no crossover (1.04 [CI, 0.89 to 1.22]; n = 35), and 100 or more patients (0.94 [CI, 0.77 to 1.14]; n = 10). In trials with two or more such attributes, relative risk was further reduced. CONCLUSIONS: Overall, no effect of albumin on mortality was detected; any such effect may therefore be small. This finding supports the safety of albumin. The influence of methodologic quality on relative risk for death suggests the need for further well-designed clinical trials.

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Crossref · 10.7326/0003-4819-135-3-200108070-00007

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Citations

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3 retracted

Research works printed but not linked: 23

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Metadata

Authors
Wilkes, M. M., & Navickis, R. J.
Affiliations
From Hygeia Associates, Grass Valley, California.
Venue
Annals of Internal Medicine
Publisher
American College of Physicians
Published
2001-08-07
Volume
135
Issue
3
Pages
149-164
ISSN
  • 0003-4819 (ISSN-L)
  • 1539-3704
DOI
10.7326/0003-4819-135-3-200108070-00007
OpenAlex
W2129198157
Cited by
486
References
112
Citations by year
2026: 5 · 2025: 4 · 2024: 5 · 2023: 10 · 2022: 2 · 2021: 5 · 2020: 6 · 2019: 11 · 2018: 9 · 2017: 11 · 2016: 18 · 2015: 12 · 2014: 17 · 2013: 14 · 2012: 24
FWCI
6.71
Type
journal article
Language
en
Open access
closed
Licence
www.acpjournals.org/journal/aim/text-and-data-mining (tdm)
Locations
  • Annals of Internal Medicine (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Critical Care and Intensive Care Medicine › Trauma, Hemostasis, Coagulopathy, Resuscitation
  • Health Sciences › Medicine › Critical Care and Intensive Care Medicine › Sepsis Diagnosis and Treatment
  • Health Sciences › Medicine › Surgery › Hemodynamic Monitoring and Therapy
Keywords
human serum albumin, albumin therapy, mortality, patient survival, hypoalbuminemia, ascites, burns, trauma (physical injury), neonates, methodological quality, trial bias, drug safety
MeSH terms
Albumins, Colloids, Critical Care, Fluid Therapy, Research Design, Risk Factors, Rehydration Solutions, Bias, Survival Analysis, Randomized Controlled Trials as Topic, Critical Illness

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