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Cited by 952Adrenal and Paraganglionic TumorsPituitary Gland Disorders and TreatmentsHormonal Regulation and Hypertension

The DOI matches its Crossref record.

Management of the clinically inapparent adrenal mass ("incidentaloma")

Grumbach, Melvin M., Biller, Beverly M.K., Braunstein, Glenn D., Campbell, Karen K., Carney, J. Aidan, Godley, Paul A., Harris, Emily L., Lee, Joseph K.T., Oertel, Yolanda C., Posner, Mitchell C., Schlechte, Janet A., Wieand, H. Samuel·2003·Annals of Internal Medicine
DOI 10.7326/0003-4819-138-5-200303040-00013
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Abstract

The National Institutes of Health Consensus Development Program convened surgeons, endocrinologists, pathologists, biostatisticians, radiologists, oncologists, and other health care professionals, as well as members of the general public, to address the causes, prevalence, and natural history of clinically inapparent adrenal masses, or "incidentalomas"; the appropriate evaluation and treatment of such masses; and directions for future research. Improvements in abdominal imaging techniques have increased detection of adrenal incidentalomas, and because the prevalence of these masses increases with age, appropriate management of adrenal tumors will be a growing challenge in our aging society. To address six predetermined questions, the 12-member nonfederal, nonadvocate state-of-the-science panel heard presentations from 21 experts in adrenal incidentalomas and consulted a systematic review of medical literature on the topic provided by the Agency for Healthcare Research and Quality and an extensive bibliography developed by the National Library of Medicine. The panel recommended a 1-mg dexamethasone suppression test and measurement of plasma-free metanephrines for all patients with an adrenal incidentaloma; additional measurement of serum potassium and plasma aldosterone concentration-plasma renin activity ratio for patients with hypertension; and surgery for patients with biochemical evidence of pheochromocytoma, patients with tumors greater than 6 cm, and patients with tumors greater than 4 cm who also meet other criteria. The panel also advocated a multidisciplinary approach to managing adrenal incidentalomas. The statement is an independent report of the panel and is not a policy statement of the National Institutes of Health or the federal government.

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Metadata

Authors
Grumbach, M. M., Biller, B. M. K., Braunstein, G. D., Campbell, K. K., Carney, J. A., Godley, P. A., Harris, E. L., Lee, J. K. T., Oertel, Y. C., Posner, M. C., Schlechte, J. A., & Wieand, H. S.
Affiliations
University of North Carolina at Chapel Hill (US)
Corresponding author
Grumbach, Melvin M.
ORCID
Schlechte, Janet A.
Venue
Annals of Internal Medicine
Publisher
American College of Physicians
Published
2003-03-04
Volume
138
Issue
5
Pages
424-429
ISSN
  • 0003-4819 (ISSN-L)
  • 1539-3704
DOI
10.7326/0003-4819-138-5-200303040-00013
OpenAlex
W2148626383
Cited by
945
References
0
Citations by year
2026: 12 · 2025: 13 · 2024: 21 · 2023: 26 · 2022: 25 · 2021: 44 · 2020: 40 · 2019: 31 · 2018: 35 · 2017: 45 · 2016: 39 · 2015: 55 · 2014: 58 · 2013: 48 · 2012: 54
FWCI
33.33
Type
journal article
Language
en
Open access
closed
Licence
www.acpjournals.org/journal/aim/text-and-data-mining (tdm)
Locations
  • Annals of Internal Medicine (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Surgery › Adrenal and Paraganglionic Tumors
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Pituitary Gland Disorders and Treatments
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Hormonal Regulation and Hypertension
Keywords
adrenal incidentaloma, adrenal tumors, dexamethasone suppression test, plasma free metanephrines, aldosterone, renin-aldosterone system, hypertension, pheochromocytoma, surgical management, tumor size, multidisciplinary management, natural history (disease)
MeSH terms
Adrenal Gland Neoplasms, Biopsy, Needle, Diagnostic Imaging, Humans, Pheochromocytoma, Prevalence, Clinical Chemistry Tests

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