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Cited by 217Hormonal and reproductive studiesMenopause: Health Impacts and TreatmentsLipoproteins and Cardiovascular Health

The DOI matches its Crossref record; 59 of the 59 references it cites were found in a registry or an index.

Endogenous Sex Hormones and Cardiovascular Disease Incidence in Men

Ärnlöv, Johan, Pencina, Michael J., Amin, Shreyasee, Nam, Byung-Ho, Benjamin, Emelia J., Murabito, Joanne M., Wang, Thomas J., Knapp, Philip E., D'Agostino, Ralph B., Bhasin, Shalendar, Vasan, Ramachandran S.·2006·Annals of Internal Medicine
DOI 10.7326/0003-4819-145-3-200608010-00005
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Abstract

BACKGROUND: Data suggest that endogenous sex hormones (testosterone, dehydroepiandrosterone sulfate [DHEA-S], and estradiol) influence cardiovascular disease (CVD) risk factors and vascular function. Yet, prospective studies relating sex hormones to CVD incidence in men have yielded inconsistent results. OBJECTIVE: To examine the association of circulating sex hormone levels and CVD risk in men. DESIGN: Prospective cohort study. SETTING: Community-based study in Framingham, Massachusetts. PARTICIPANTS: 2084 middle-aged white men without CVD at baseline. MEASUREMENTS: The authors used multivariable Cox regression to relate baseline levels of testosterone, DHEA-S, and estradiol to the incidence of CVD (coronary, cerebrovascular, or peripheral vascular disease or heart failure) during 10 years of follow-up. RESULTS: During follow-up, 386 men (18.5%) experienced a first CVD event. After adjustment for baseline standard CVD risk factors, higher estradiol level was associated with lower risk for CVD (hazard ratio per SD increment in log estradiol, 0.90 [95% CI, 0.82 to 0.99]; P = 0.035). The authors observed effect modification by age: Higher estradiol levels were associated with lower CVD risk in older (median age >56 years) men (hazard ratio per SD increment, 0.86 [CI, 0.78 to 0.96]; P = 0.005) but not in younger (median age < or =56 years) men (hazard ratio per SD increment, 1.11 [CI, 0.89 to 1.38]; P = 0.36). The association of higher estradiol level with lower CVD incidence remained robust in time-dependent Cox models (updating standard CVD risk factors during follow-up). Serum testosterone and DHEA-S levels were not statistically significantly associated with incident CVD. LIMITATIONS: Sex hormone levels were measured only at baseline, and the findings may not be generalizable to women and nonwhite people. CONCLUSIONS: In the community-based sample, a higher serum estradiol level was associated with lower risk for CVD events in older men. The findings are consistent with the hypothesis that endogenous estrogen has vasculoprotective influences in men.

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  1. 10.1210/jcem.87.8.8762 · DOI
  2. Tilvis RS, 1999, Aging (Milano), 11, 30
  3. Kajinami K, 2004, Coron Artery Dis, 15, 199
  4. Jilma B, 1996, J Clin Endocrinol Metab, 81, 2350
  5. Ohshige A, 1996, Artery, 22, 115
  6. 1967, Surg Gynecol Obstet, 124, 1011

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Metadata

Authors
Ärnlöv, J., Pencina, M. J., Amin, S., Nam, B.-H., Benjamin, E. J., Murabito, J. M., Wang, T. J., Knapp, P. E., D'Agostino, R. B., Bhasin, S., & Vasan, R. S.
Affiliations
  • Boston University (US)
  • From the National Heart, Lung, and Blood Institute's Framingham Heart Study, National Institutes of Health, Bethesda, Maryland; Boston University School of Medicine, Boston University, Massachusetts General Hospital, and Harvard Medical School, Boston, Massachusetts; Mayo Clinic College of Medicine, Rochester, Minnesota; and Uppsala University, Uppsala, Sweden.
ORCID
Venue
Annals of Internal Medicine
Publisher
American College of Physicians
Published
2006-08-01
Volume
145
Issue
3
Pages
176-184
ISSN
  • 0003-4819 (ISSN-L)
  • 1539-3704
DOI
10.7326/0003-4819-145-3-200608010-00005
OpenAlex
W1550493347
Cited by
217
References
59
Citations by year
2025: 5 · 2024: 5 · 2023: 3 · 2022: 12 · 2021: 8 · 2020: 5 · 2019: 8 · 2018: 9 · 2017: 4 · 2016: 11 · 2015: 11 · 2014: 12 · 2013: 16 · 2012: 19
FWCI
12.00
Type
journal article
Language
en
Open access
closed
Licence
www.acpjournals.org/journal/aim/text-and-data-mining (tdm)
Locations
  • Annals of Internal Medicine (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • National Institutes of Health (5k23hl074077-03, n01hc25195-41-0-1)
  • National Heart, Lung, and Blood Institute (2K24 HL 04334, N01‐HC25195, K23-HL-074077, K24HL004334)
  • National Institute of Neurological Disorders and Stroke (6R01NS17950, R01NS017950)
Topics
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Hormonal and reproductive studies
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Menopause: Health Impacts and Treatments
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Lipoproteins and Cardiovascular Health
Keywords
endogenous sex hormones, cardiovascular disease incidence, estradiol, testosterone, dehydroepiandrosterone sulfate, men, coronary artery disease, cerebrovascular disease, peripheral vascular disease, heart failure, age effect modification, vascular protection, Framingham Heart Study
MeSH terms
Cardiovascular Diseases, Estradiol, Follow-Up Studies, Humans, Male, Massachusetts, Middle Aged, Prospective Studies, Risk Factors, Testosterone, Incidence, Dehydroepiandrosterone Sulfate

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