Review of Comparative Effectiveness of Treatments to Prevent Fractures

Abstract

Letters3 June 2008Review of Comparative Effectiveness of Treatments to Prevent FracturesCatherine MacLean, MD, PhD, Margaret Maglione, MPP, and Marika Suttorp, MSCatherine MacLean, MD, PhDFrom RAND Corporation, Santa Monica, CA 90401.Search for more papers by this author, Margaret Maglione, MPPFrom RAND Corporation, Santa Monica, CA 90401.Search for more papers by this author, and Marika Suttorp, MSFrom RAND Corporation, Santa Monica, CA 90401.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-148-11-200806030-00021 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail IN RESPONSE:Dr. Rosen is correct. The study he references (1) was included in our analysis but was not called out in the section on renal insufficiency. This trial reported the effect of risedronate on fractures among participants with varying degrees of renal insufficiency. This study, which combined data from 9 randomized, double-blind, placebo-controlled trials, reported a reduced incidence of vertebral fractures with risedronate compared with placebo in participants with severe, moderate, and mild renal insufficiency.Although not reported in our paper, we did collect data and calculate pooled estimates for all adverse events reported in all studies reviewed. Details ...References1. Miller PD, Roux C, Boonen S, Barton IP, Dunlap LE, Burgio DE. Safety and efficacy of ris…