Cited by 250Lipoproteins and Cardiovascular HealthDementia and Cognitive Impairment ResearchCancer-related cognitive impairment studies

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Statins and Cognitive Function: A Systematic Review

Richardson, Karl, Schoen, Marisa, French, Benjamin, Umscheid, Craig A., Mitchell, Matthew D., Arnold, Steven E., Heidenreich, Paul A., Rader, Daniel J., deGoma, Emil M.·2013·Annals of Internal Medicine

DOI 10.7326/0003-4819-159-10-201311190-00007

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Abstract

Background Despite the U.S. Food and Drug Administration (FDA) warning regarding cognitive impairment, the relationship between statins and cognition remains unknown. Purpose To examine the effect of statins on cognition. Data sources PubMed, Embase, and Cochrane Library from inception through October 2012; FDA databases from January 1986 through March 2012. Study selection Randomized, controlled trials (RCTs) and cohort, case-control, and cross-sectional studies evaluating cognition in patients receiving statins. Data extraction Two reviewers extracted data, 1 reviewer assessed study risk of bias, and 1 reviewer checked all assessments. Data synthesis Among statin users, low-quality evidence suggested no increased incidence of Alzheimer disease and no difference in cognitive performance related to procedural memory, attention, or motor speed. Moderate-quality evidence suggested no increased incidence of dementia or mild cognitive impairment or any change in cognitive performance related to global cognitive performance scores, executive function, declarative memory, processing speed, or visuoperception. Examination of the FDA postmarketing surveillance databases revealed a low reporting rate for cognitive-related adverse events with statins that was similar to the rates seen with other commonly prescribed cardiovascular medications. Limitations The absence of many well-powered RCTs for most outcomes resulted in final strengths of evidence that were low or moderate. Imprecisio…

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2018 AHA/ACC/AACVPR/AAPA/ABC/ACPM/ADA/AGS/APhA/ASPC/NLA/PCNA Guideline on the Management of Blood Cholesterol: A Report of the American College of Cardiology/American Heart Association Task Force on Clinical Practice Guidelines
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See all 250

Authors: Richardson, K., Schoen, M., French, B., Umscheid, C. A., Mitchell, M. D., Arnold, S. E., Heidenreich, P. A., Rader, D. J., & deGoma, E. M.
Affiliations: Stanford Medicine (US)
ORCID: Richardson, Karl
French, Benjamin
Umscheid, Craig A.
Mitchell, Matthew D.
Arnold, Steven E.
Heidenreich, Paul A.
Rader, Daniel J.
deGoma, Emil M.
Venue: Annals of Internal Medicine
Publisher: American College of Physicians
Published: 2013-11-19
Volume: 159
Issue: 10
Pages: 688-697
ISSN: 0003-4819 (ISSN-L)
1539-3704
DOI: 10.7326/0003-4819-159-10-201311190-00007
OpenAlex: W2017872978
Cited by: 250
References: 84
Citations by year: 2026: 10 · 2025: 12 · 2024: 8 · 2023: 8 · 2022: 12 · 2021: 12 · 2020: 16 · 2019: 24 · 2018: 25 · 2017: 19 · 2016: 41 · 2015: 34 · 2014: 28 · 2013: 1
FWCI: 6.14
Type: journal article
Language: en
Open access: closed
Licence: www.acpjournals.org/journal/aim/text-and-data-mining (tdm)
Locations: Annals of Internal Medicine (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Lipoproteins and Cardiovascular Health
Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
Health Sciences › Medicine › Oncology › Cancer-related cognitive impairment studies
Keywords: statins, cognitive function, cognitive impairment, Alzheimer's disease, dementia, mild cognitive impairment, executive function, memory, processing speed, post-marketing surveillance, adverse drug reactions, high-intensity statin therapy
MeSH terms: Alzheimer Disease, Cognition Disorders, Dementia, Humans, Memory Disorders, United States, United States Food and Drug Administration, Adverse Drug Reaction Reporting Systems, Hydroxymethylglutaryl-CoA Reductase Inhibitors

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Statins and Cognitive Function: A Systematic Review

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