METHYLTESTOSTERONE THERAPY FOR HEREDITARY EPISODIC EDEMA (HEREDITARY ANGIONEUROTIC EDEMA)

Abstract

Article1 October 1960METHYLTESTOSTERONE THERAPY FOR HEREDITARY EPISODIC EDEMA (HEREDITARY ANGIONEUROTIC EDEMA)W. B. SPAULDING, M.D., F.R.C.P. (C)W. B. SPAULDING, M.D., F.R.C.P. (C)Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-53-4-739 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptHereditary episodic edema is a rare disease, manifested by recurring attacks of spreading edema which appear rapidly, last only a few days, and leave the patient healthy between episodes. The hereditary pattern is that of a dominant genetic abnormality. The edema may involve the skin or the wall of the mouth, pharynx, larynx or gastrointestinal tract. Edema of the larynx constitutes a grave emergency which may cause death. The clinical features in two families studied personally and in others reported in the literature have previously been reviewed in detail.1Although knowledge of the clinical manifestations, heredity and prognosis is adequate,...Bibliography1. Spaulding WB: Hereditary angioneurotic oedema in two families, Canad. M. A. J. 73: 181, 1955. MedlineGoogle Scholar2. HamiltonMontagna JBW: The sebaceous glands of the hamster. I. Morphological effects of androgens on integumentary structures, Am. J. Anat. 86: 191, 1950. CrossrefMedlineGoogle Scholar3. DorfmanShipley RIRA: Androgens. Biochemistry, physiology and clinical significance, 1956, John Wiley & Sons, Inc., New York, p. 384. Google Scholar4. WernerHangerKritzler SCFMRA: Jaundice during methyltestosterone therapy, Am. J. Med. 8: 325, 1950. CrossrefMedlineGoogle Scholar5. Koszalka MF: Medical obstructive jaundice. Report of a death due to methyltestosterone, Journal-Lancet 77: 51, 1957. MedlineGoogle Scholar6. Heckel NJ: The influence of testosterone-propionate upon benign prostatic hypertrophy and spermatogenesis: a clinical and pathological study in the human, J. Urol. 43: 286, 1940. CrossrefGoogle Scholar7. McCullaghRossmiller EPHR: Methyltestosterone. 1. Androgenic effects and the production of gynecomastia and oligospermia, J. Clin. Endocrinol. 1: 496, 1941. CrossrefGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Toronto,*Received for publication March 16, 1960.From the Department of Medicine, University of Toronto, and the Medical Service, Toronto General Hospital.Requests for reprints should be addressed to W. B. Spaulding, M.D., Toronto General Hospital, Toronto,Canada. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byTrends in Treatments With Disease-Specific and Interfering Drugs in Patients With Hereditary Angioedema in SwedenAttenuated androgen discontinuation in patients with hereditary angioedema: a commented case seriesHereditary AngioedemaAndrogen use in hereditary angioedema: A critical appraisal and approaches to transitioning from androgens to other therapiesProphylaxe von AngioödemenBradykinin-Mediated Angioedema Across the HistoryThe Story of Angioedema: from Quincke to BradykininProphylaxis in hereditary angioedema (HAE) with C1 inhibitor deficiencyProphylaxe beim hereditären Angioödem (HAE) mit C1-InhibitormangelDiagnosis and Management of Hereditary Angioedema: An Emergency Medicine PerspectiveAndrogen therapy in non-gonadal diseaseLife with Hereditary Angioedema: Then and NowHAE therapies: past present and futureAn Overview of Novel Therapies for Acute Hereditary AngioedemaHereditary Angioedema in Oral Surgery: Overview of the Clinical Picture and Report of a CaseHereditary Angioedema in ChildhoodC1-inhibitor deficiency and angioedema: molecular mechanisms and clinical progressNew promise and hope for treating hereditary angioedemaBenefits and risks of danazol in hereditary angioedema: a long-term survey of 118 patientsHereditary angioedema: a current state-of-the-art review, II: historical perspective ofnon-histamine-induced angioedemaHereditary angiodema: a current state-of-the-art review, IV: short- and long-term treatment of hereditary angioedema: out with the old and in with the new?New therapies for hereditary angioedema: Disease outlook changes dramaticallyAngioedemaHereditary angioedema: Optimal therapyThe deficiency of C1 inhibitor and its treatmentTreatment of hereditary angioneurotic oedema (HANE) with tiboloneHereditary Angioedema: The Clinical Syndrome and its Management in the United StatesNovel Therapies for Hereditary AngioedemaHereditary angioedemaHereditary angioedemaAngioedemaC1 inhibitor deficiency: consensus documentCurrent and future therapy for hereditary angioedemaHereditary angioedema: The rewards of studying a rare diseaseA tracheostomy obturator for a patient with hereditary angioneurotic edemaHow do we treat patients with hereditary angioedemaProtease inhibitors in the treatment of hereditary angioedemaDiagnosis and management of hereditary angioedema: an American ap