The Natural History of Autoimmune Disease in NZB Mice: A Comparison with the Pattern of Human Autoimmune Manifestations

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Article1 September 1963The Natural History of Autoimmune Disease in NZB MiceA Comparison with the Pattern of Human Autoimmune ManifestationsMARGARET C. HOLMES, PH.D., F. M. BURNET, M.D., F.R.C.P., F.R.A.C.P.MARGARET C. HOLMES, PH.D.Search for more papers by this author, F. M. BURNET, M.D., F.R.C.P., F.R.A.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-59-3-265 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptAll mice of the NZB/Bl strain spontaneously develop serological and pathological evidence of autoimmune disease during adult life. The NZB/Bl strain was developed by Dr. Marianne Bielschowsky in Dunedin, New Zealand, by inbreeding from an outbred colony of mixed coat color. Several inbred strains—NZB, NZC, NZO, NZW, NZY, and others, have been evolved in Dunedin from the original colony. Evidence for autoimmune disease in the NZB strain was first reported by Bielschowsky, Helyer, and Howie (1) who found evidence of an autoimmune hemolytic anemia. The Dunedin group used the presence of agglutinins for ficin-treated red cells as the index of...References1. BIELSCHOWSKYHELYERHOWIE MBJJB: Proc. Univ. Otago Med. School 37: 9, 1959. Google Scholar2. HOLMESGORRIEBURNET MCJFM: Lancet ii: 638, 1961. CrossrefGoogle Scholar3. HELYERHOWIE BJJB: Proc. Univ. Otago Med. School 39: 3, 1961. Google Scholar4. NORINS L: Unpublished work, 1963. Google Scholar5. COOMBSMOURANTRACE RAAERA: Lancet I: 264, 1946. CrossrefGoogle Scholar6. LONGHOLMESBURNET GMCFM: Aust. J. Exp. Biol. Med. (in press), 1963. MedlineGoogle Scholar7. BATEMAN N: Nature 191: 271, 1961. CrossrefGoogle Scholar8. DACIE JV: The Haemolytic Anaemias: Congenital and Acquired. Part 2, 2d ed., J & A Churchill Ltd., London. Google Scholar9. BURNET FM: Aust. Ann. Med. 11: 79, 1962. MedlineGoogle Scholar10. BURNET FM: Brit. Med. J. 2: 807, 1962. CrossrefMedlineGoogle Scholar11. BURNET FM: Proceedings, Thymus Conference, Minneapolis, Minnesota (in press), 1963. Google Scholar12. BURNETHOLMES FMMC: 1963. Google Scholar13. SMITH M: Proceedings, Thymus Conference, Minneapolis, Minnesota (in press), 1963. Google Scholar14. HELYERHOWIE BJJB: Nature 197: 197, 1963. CrossrefMedlineGoogle Scholar15. WEIDENGILTINAN SP: Unpublished work, 1963. Google Scholar16. HOLMESBURNET MCFM: Aust. J. Exp. Biol. Med. (in press), 1963. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: MARGARET C. HOLMES, PH.D.; F. M. BURNET, M.D., F.R.C.P., F.R.A.C.P.Affiliations: Melbourne,Presented as the Lilly Lecture at the Forty-fourth Annual Session of the American College of Physicians, Denver, Colorado, April 1-5, 1963.From The Walter and Eliza Hall Institute of Medical Research, Melbourne, Australia.Request for reprints should be addressed to Sir Macfarlane Burnet, M.D., The Walter and Eliza Hall Institute of Medical Research, Melbourne, Australia. Nextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byRole of the Immune System in HypertensionScientific and Regulatory Policy Committee Points-to-consider Paper*Fashioning the Immunological Self: The Biological Individuality of F. Macfarlane BurnetExome sequencing of senescence-accelerated mice (SAM) reveals deleterious mutations in degenerative disease-causing genesBone marrow of NZB/W mice is the major site for plasma cells resistant to dexamethasone and cyclophosphamide: Implications for the treatment of autoimmunityAutoantibody Associated Disorders of the CNS in Children: The List Keeps GrowingLocal Renal Autoantibody Production in Lupus NephritisThe main product of specialized tissues regulates cell life and may cause neoplastic transformationTravels and travails of autoimmunity: A historical journey from discovery to rediscoveryIgG glycosylation in autoimmune-prone strains of miceThe Influence of Neonatal Thymectomy and Thymus Grafting on Spontaneous Auto-Immune Disease in MiceChapter 19 Estrogen in Systemic Lupus Erythematosus: Lessons from the SELENA StudyFcγ receptors as regulators of immune responsesFcγRIIb controls bone marrow plasma cell persistence and apoptosisFc‐Receptors as Regulators of ImmunityLessons from animal models of vasculitisGenetic Aspects of Inherent B-cell Abnormalities Associated with SLE and B-cell Malignancy: Lessons from New Zealand Mouse ModelsVasculitis in the Palmerston North mouse model of lupus: Phenotype and cytokine production profile of infiltrating cellsAdministration of Dehydroepiandrosterone Sulfate Retards Onset but not Progression of Autoimmune Disease in NZB/W MiceRoots of and Routes to AutoimmunityHemolytic anemia in non-obese diabetic miceImmunological function of kidney-infiltrating lymphocytes from aged NZB miceLiver composition and lipid metabolism in NZB/W F1 female mice fed dehydroisoandrosteroneBehavioral approach to probe altered neurotra