Risk Factors in Coronary Heart Disease: An Evaluation of Several Serum Lipids as Predictors of Coronary Heart Disease

Abstract

Article1 November 1964Risk Factors in Coronary Heart DiseaseThe Framingham StudyWILLIAM B. KANNEL, M.D., F.A.C.P., THOMAS R. DAWBER, M.D., F.A.C.P., GARY D. FRIEDMAN, M.D., WILLIAM E. GLENNON, M.S., PATRICIA M. MCNAMARAWILLIAM B. KANNEL, M.D., F.A.C.P.Search for more papers by this author, THOMAS R. DAWBER, M.D., F.A.C.P.Search for more papers by this author, GARY D. FRIEDMAN, M.D.Search for more papers by this author, WILLIAM E. GLENNON, M.S.Search for more papers by this author, PATRICIA M. MCNAMARASearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-61-5-888 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptAt Framingham, Massachusetts, the National Heart Institute has been following 5,127 men and women aged 30 to 60 years in a study of factors related to the development of coronary heart disease (CHD) and hypertension. Data for a decade of follow-up studies of this population are available for analysis.From a study of those who have developed disease under observation in comparison to those who have remained free of the disease, factors of risk and susceptible individuals have been identified. The factors associated with excess risk that have been identified are: serum cholesterol level, blood pressure, cigarette smoking, vital capacity,...References1. GORDONMOORESHURTLEFFDAWBER TFEDTR: Some methodologic problems in the long-term study of cardiovascular disease: observations on the Framingham Study. J. Chron. Dis. 10: 186, 1959. CrossrefGoogle Scholar2. KANNELDAWBERKAGANREVOTSKIESTOKES WBTRANJ: Factors of risk in the development of coronary heart disease—six-year follow-up experience: The Framingham Study. Ann. Intern. Med. 55: 33, 1961. LinkGoogle Scholar3. KAHN HA: A method for analyzing longitudinal observations on individuals in the Framingham Heart Study. Proceedings of the Social Statistics Section of the American Statistical Association, 1961. Google Scholar4. DELALLAGOFMAN OFJW: Ultracentrifugal analysis of serum lipoprotein, in Methods of Biochemical Analysis, vol. 1, edited by GLICK, D., Interscience, New York, 1954, pp. 459-478. Google Scholar5. ABELLLEVYBRODIEKENDALL LLBBBBFE: A simplified method for estimation of total cholesterol in serum and demonstration of its specificity. J. Biol. Chem. 195: 357, 1952. CrossrefMedlineGoogle Scholar6. YOUNGBURGYOUNGBURG GEMV: Phosphorus metabolism; system of blood phosphorus analysis. J. Lab. Clin. Med. 16: 158, 1930. Google Scholar7. FISKESUBARROW CHY: The colorimetric determination of phosphorus. J. Biol. Chem. 66: 375, 1925. CrossrefGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Framingham, MassachusettsFrom the Heart Disease Epidemiology Study, Framingham, Mass., and the National Heart Institute, National Institutes of Health, U. S. Public Health Service, Bethesda, Md.Requests for reprints should be addressed to William B. Kannel, M.D., Heart Disease Epidemiology Study, Dept. of Health, Education, and Welfare, 25 Evergreen St., Framingham, Mass. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByLEGACY: Phase 2a Trial to Evaluate the Safety, Pharmacokinetics, and Pharmacodynamic Effects of the Anti-EL (Endothelial Lipase) Antibody MEDI5884 in Patients With Stable Coronary Artery DiseaseEfficacy of dulaglutide on vascular health indexes in subjects with type 2 diabetes: a randomized trialGenetic Determinants of Plasma Low-Density Lipoprotein Cholesterol Levels: Monogenicity, Polygenicity, and “Missing” HeritabilityGesättigte Fettsäuren und kardiovaskuläres RisikoThe burden of cholesterol accumulation through the lifespan: why pharmacological intervention should start earlier to go further?Is a High HDL-Cholesterol Level Always Beneficial?Milk fat: opportunities, challenges and innovationRisk and protective factors for intuitive and rational judgment of cybersecurity risks in a large sample of K-12 students and teachersLong-term exposure to ambient air pollution is associated with coronary artery calcification among asymptomatic adultsADAM17 Boosts Cholesterol Efflux and Downstream Effects of High-Density Lipoprotein on Inflammatory Pathways in MacrophagesRapid Decrease in HDL-C in the Puberty Period of Boys Associated with an Elevation of Blood Pressure and Dyslipidemia in Korean Teenagers: An Explanation of Why and When Men Have Lower HDL-C Levels Than WomenCeramide Scores Predict Cardiovascular Risk in the CommunityIntegrating lipidomics and genomics: emerging tools to understand cardiovascular diseasesRelationship between lipoproteins, thrombosis, and atrial fibrillationImpact of Blood Pressure Visit‐to‐Visit Variability on Adverse Events in Patients With Nonvalvular Atrial Fibrillation: Subanalysis of the J‐RHYTHM RegistryHow ApoB Measurements Could Improve Prevention of