The DOI matches its Crossref record.
Quantitative Relationships Between Circulating Leukocytes and Infection in Patients with Acute Leukemia
Abstract
Article1 February 1966Quantitative Relationships Between Circulating Leukocytes and Infection in Patients with Acute LeukemiaGERALD P. BODEY, M.D., MONICA BUCKLEY, B.A., Y. S. SATHE, PH.D., EMIL J FREIREICH, M.D.GERALD P. BODEY, M.D., MONICA BUCKLEY, B.A., Y. S. SATHE, PH.D., EMIL J FREIREICH, M.D.Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-64-2-328 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptInfection is currently the major fatal complication of acute leukemia (1). Previous studies have indicated a relationship between leukopenia and the presence of infection in patients with acute leukemia (2-4) and various types of agranulocytosis (5-7). Chemotherapeutic agents with bone marrow toxicity are being used with increasing frequency in malignant and other chronic diseases. Also, a high incidence of infection has accompanied the use of these agents as immunosuppressive therapy in patients receiving organ transplantation (8). The present study examines the quantitative relationships between the presence of infection and the degree and duration of leukopenia in patients with acute leukemia....References1. HERSHBODEYNIESFREIREICH EMGPBAEJ: The causes of death in acute leukemia. A study of 414 patients from 1954-1963. JAMA 193: 105, 1965. CrossrefMedlineGoogle Scholar2. MILLERSHANBROM SPE: Infectious syndromes of leukemias and lymphomas. Amer. J. Med. Sci. 246: 420, 1963. CrossrefMedlineGoogle Scholar3. SILVERBEALSCHNEIDERMANMCCULLOUGH RTGAMANB: The role of the mature neutrophil in bacterial infections in acute leukemia. Blood 12: 814, 1957. CrossrefMedlineGoogle Scholar4. BAKER RD: Leukopenia and therapy in leukemia as factors predisposing to fatal mycoses. Mucormycosis, aspergillosis, and cryptococcosis. Amer. J. Clin. Path. 37: 358, 1962. CrossrefMedlineGoogle Scholar5. BROWNEMARCUS EAAJ: Chronic idiopathic neutropenia. New Eng. J. Med. 262: 795, 1960. CrossrefMedlineGoogle Scholar6. KOSTMANN R: Infantile genetic agranulocytosis. Acta Paediat. (Stockholm) (Supplement 105) 45: 1, 1956. MedlineGoogle Scholar7. SPAETDAMESHEK THW: Chronic hypoplastic neutropenia. Amer. J. Med. 13: 35, 1952. CrossrefMedlineGoogle Scholar8. HILLROLLAROWLANDSRIFKIND JBDTD: Infectious pulmonary disease in patients receiving immunosuppressive therapy for organ transplantation. New Eng. J. Med. 271: 1021, 1964. CrossrefMedlineGoogle Scholar9. FREIKARONLEVINFREIREICHTAYLORHANANIANSELAWRYHOLLANDHOOGSTRATENWOLMANABIRSAWITSKYLEEMILLSBURGERTSPURRPATTERSONEBAUGHJAMESMOON EMRHEJRJJOJFBIJEASSDEOCLRBFGGWJH: Effectiveness of combinations of antileukemic agents in inducing and maintaining remission in children with acute leukemia. In press. Google Scholar10. LEVINHENDERSONKARONFREIREICH RHEMEJ: Treatment of acute leukemia with methylglyoxal-bis-guanylhydrazone (Methyl GAG). Clin. Pharmacol. Ther. 6: 31, 1965. CrossrefMedlineGoogle Scholar11. RICHARBREAKELL WJES: Evaluation of an electronic particle counter for the counting of white blood cells. Amer. J. Clin. Path. 31: 384, 1959. CrossrefMedlineGoogle Scholar12. BISEL HF: Criteria for the evaluation of response to treatment in acute leukemia. Blood 11: 676, 1956. Google Scholar13. WINTROBE MM: Clinical Hematology, 5th ed. Lea & Febiger, Philadelphia, 1961, p. 254. Google Scholar14. MCFARLANDLEBRE WEP: Abnormal leukocyte response in alcoholism. Ann. Intern. Med. 59: 865, 1963. LinkGoogle Scholar15. BOGGSWINTROBECARTWRIGHT DRMGE: The acute leukemias. Analysis of 322 cases and review of the literature. Medicine (Balt.) 41: 163, 1962. CrossrefMedlineGoogle Scholar16. BOGGSFREI DRE: Clinical studies of fever and infection in cancer. Cancer 13: 1240, 1960. CrossrefGoogle Scholar17. HERSHCARBONEWONGFREIREICH EMPPVGEJ: Inhibition of the primary immune response in man by antimetabolites. Cancer Res. In press. Google Scholar18. JAFFE RH: Morphology of the inflammatory defense reactions in leukemia. Arch. Path. (Chicago) 14: 177, 1932. Google Scholar19. BRAUDEFELTESBROOKS AIJM: Differences between the activities of mature granulocytes in leukemic and normal blood. J. Clin. Invest. 33: 1036, 1954. CrossrefMedlineGoogle Scholar20. BOGGS DR: The cellular composition of inflammatory exudates in human leukemias. Blood 15: 466, 1960. CrossrefMedlineGoogle Scholar21. PERILLIEFINCH PEC: The local exudative cellular response in leukemia. J. Clin. Invest. 39: 1353, 1960. CrossrefMedlineGoogle Scholar22. PERILLIEFINCH PESC: Quantitative studies of the local exudative cellular reaction in acute leukemia. J. Clin. Invest. 43: 425, 1964. CrossrefMedlineGoogle Scholar23. PAGEGOOD ARRA: A clinical and experimental study of the function of neutrophils in the inflammatory response. Amer. J. Path. 34: 645, 1958. MedlineGoogle Scholar24. RAABHOEPRICHWINTROBECARTWRIGHT SOPDMMGE: The clinical significance of fever in acute leukemia. Blood 16: 1609, 1960. CrossrefMedlineGoogle Scholar25. MILLER CP: The effect of irr
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cited by
Freifeld, A. G., Bow, E. J., Sepkowitz, K. A., Boeckh, M. J., Ito, J. I., Mullen, C. A., Raad, I. I., Rolston, K. V., Young, J.-A. H., & Wingard, J. R. (2011) · Clinical Infectious Diseases · doi:10.1093/cid/cir073 · Cited by 3,463
2002 guidelines for the use of antimicrobial agents in neutropenic patients with cancer
Hughes, W. T., Armstrong, D., Bodey, G. P., Bow, E. J., Brown, A. E., Calandra, T., Feld, R., Pizzo, P. A., Rolston, K. V. I., Shenep, J. L., et al. (2002) · Clinical Infectious Diseases · doi:10.1086/339215 · Cited by 1,964
Self-citationRomani, L. (2011) · Nature Reviews Immunology · doi:10.1038/nri2939 · Cited by 1,793
The Human Hematopoietic Colony-Stimulating Factors
Clark, S. C., & Kamen, R. (1987) · Science · doi:10.1126/science.3296190 · Cited by 1,639
Gabrilove, J. L., Jakubowski, A., Scher, H., Sternberg, C., Wong, G., Grous, J., Yagoda, A., Fain, K., Moore, M. A. S., Clarkson, B., et al. (1988) · New England Journal of Medicine · doi:10.1056/nejm198806023182202 · Cited by 938
Metadata
- Authors
- BODEY, G. P., BUCKLEY, M., SATHE, Y. S., & FREIREICH, E. J.
- Venue
- Annals of Internal Medicine
- Publisher
- American College of Physicians
- Published
- 1966-02-01
- Volume
- 64
- Issue
- 2
- Pages
- 328-340
- ISSN
- 0003-4819 (ISSN-L)
- 1539-3704
- OpenAlex
- W2096104385
- Cited by
- 2,469
- References
- 0
- FWCI
- 10.69
- Type
- journal article
- Language
- en
- Open access
- closed
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Quantitative Relationships Between Circulating Leukocytes and Infection in Patients with Acute Leukemia. https://app.cochat.ai/papers/10.7326/0003-4819-64-2-328
- The paper
- BODEY, G. P., BUCKLEY, M., SATHE, Y. S., & FREIREICH, E. J. (1966). Quantitative Relationships Between Circulating Leukocytes and Infection in Patients with Acute Leukemia. Annals of Internal Medicine. https://doi.org/10.7326/0003-4819-64-2-328
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
