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Soft-Tissue Sarcomas, Breast Cancer, and Other Neoplasms: A Familial Syndrome?
Abstract
Four families were identified in which a pair of children had soft-tissue sarcomas: three sets of sibs and one set of cousins. One parent of each affected child developed cancer; carcinoma of the breast occurred in three mothers under 30 years of age. Other young adults in these families had a high frequency of cancer, with no evidence of underlying genetic disorders known to carry a high risk of neoplasia. The increased familial susceptibility to cancer was manifested not only by the large number of members affected but by a seeming excess of multiple primary neoplasms. These findings suggest a new "familial" syndrome of neoplastic diseases in which heredity or oncogenic agents, or both, may have a causal role.
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Cited by
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Malkin, D., Li, F. P., Strong, L. C., Fraumeni, J. F., Nelson, C. E., Kim, D. H., Kassel, J., Gryka, M. A., Bischoff, F. Z., Tainsky, M. A., et al. (1990) · Science · doi:10.1126/science.1978757 · Cited by 3,765
Self-citationWhen mutants gain new powers: News from the mutant p53 field
Brosh, R., & Rotter, V. (2009) · Nature Reviews Cancer · doi:10.1038/nrc2693 · Cited by 1,132
Gain of function of a p53 hot spot mutation in a mouse model of Li-Fraumeni syndrome
Lang, G. A., Iwakuma, T., Suh, Y.-A., Liu, G., Rao, V. A., Parant, J. M., Valentin-Vega, Y. A., Terzian, T., Caldwell, L. C., Strong, L. C., et al. (2004) · Cell · doi:10.1016/j.cell.2004.11.006 · Cited by 1,069
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Metadata
- Authors
- LI, F. P., & FRAUMENI, J. F.
- Venue
- Annals of Internal Medicine
- Publisher
- American College of Physicians
- Published
- 1969-10-01
- Volume
- 71
- Issue
- 4
- Pages
- 747-752
- ISSN
- 0003-4819 (ISSN-L)
- 1539-3704
- OpenAlex
- W2007023752
- Cited by
- 1,509
- References
- 0
- FWCI
- 3.25
- Type
- journal article
- Language
- en
- Open access
- closed
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- The paper
- LI, F. P., & FRAUMENI, J. F. (1969). Soft-Tissue Sarcomas, Breast Cancer, and Other Neoplasms: A Familial Syndrome? Annals of Internal Medicine. https://doi.org/10.7326/0003-4819-71-4-747
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
