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Epidemiology of Systemic Sclerosis (Scleroderma)
Abstract
A large-scale epidemiologic study of scleroderma was completed, including 86 patients who met specified criteria and who were hospital-diagnosed from 1947 through 1968. The average annual incidence was 2.7 new patients per million population, with rates three times higher in females than males for both whites and negroes. No significant racial differences in incidence were observed. There were few childhood cases compared with adult cases, and no male scleroderma patient under age 25 was identified. Incidence increased with age, peaking in the oldest age group studied (65+ years). No socioeconomic variables affecting scleroderma incidence were identified, nor was there epidemiologic evidence of an infectious agent contributing to its cause. The observed age, race, and sex pattern of occurrence of scleroderma resembles that of adult rheumatoid arthritis. Considering the occurrence of vascular lesions in scleroderma, these epidemiologic data suggest a sex- and age-influenced vascular abnormality involved in this disease.
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Cited by
Preliminary criteria for the classification of systemic sclerosis (scleroderma)
Masi, A. T., & Subcommittee For Scleroderma Criteria of the American Rheumatism Association Diagnostic and Therapeutic Criteria Committee (1980) · Arthritis & Rheumatism · doi:10.1002/art.1780230510 · Cited by 4,898
Self-citationEpidemiology and estimated population burden of selected autoimmune diseases in the United States
Jacobson, D. L., Gange, S. J., Rose, N. R., & Graham, N. M. H. (1997) · Clinical Immunology and Immunopathology · doi:10.1006/clin.1997.4412 · Cited by 1,667
Mimori, T., Akizuki, M., Yamagata, H., Inada, S., Yoshida, S., & Homma, M. (1981) · Journal of Clinical Investigation · doi:10.1172/jci110295 · Cited by 448
Gender differences in skin: A review of the literature
Dao, H., & Kazin, R. A. (2007) · Gender Medicine · doi:10.1016/s1550-8579(07)80061-1 · Cited by 199
Phuong, C., & Maibach, H. I. (2017) · Textbook of Aging Skin · doi:10.1007/978-3-662-47398-6_93 · Cited by 16
Metadata
- Authors
- MEDSGER, T. A., & MASI, A. T.
- Venue
- Annals of Internal Medicine
- Publisher
- American College of Physicians
- Published
- 1971-05-01
- Volume
- 74
- Issue
- 5
- Pages
- 714-721
- ISSN
- 0003-4819 (ISSN-L)
- 1539-3704
- OpenAlex
- W2065830768
- Cited by
- 275
- References
- 0
- FWCI
- 3.25
- Type
- journal article
- Language
- en
- Open access
- closed
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- MEDSGER, T. A., & MASI, A. T. (1971). Epidemiology of Systemic Sclerosis (Scleroderma). Annals of Internal Medicine. https://doi.org/10.7326/0003-4819-74-5-714
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