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Defective Neutrophil Chemotaxis and Cellular Immunity in a Child with Recurrent Infections
Abstract
Studies of leukocyte function and cell-mediated immunity were done in an 11-year-old girl with a lifelong history of recurrent pyogenic and mucocutaneous candida infections. An intrinsic cellular defect in neutrophil chemotaxis was found with the Boyden chamber method. Family members had normal chemotaxis, and the patient's serum was capable of generating normal amounts of chemotactic factors. This in vitro defect correlated with a reduction in leukocyte migration in vivo by the skin window method, but all other aspects of neutrophil function, including phagocytosis, bactericidal activity, metabolic activity, and passive motility, were normal. Studies of cellular immunity disclosed negative delayed cutaneous reactions to antigens from Candida albicans and failure of in vitro production of migration inhibitory factor. The cellular defect in leukocyte chemotaxis and the abnormalities in cellular immunity in this child may be important factors in her marked susceptibility to infections.
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Cited by
Hill, H., & Quie, P. (1974) · The Lancet · doi:10.1016/s0140-6736(74)92493-3 · Cited by 326
Neutrophil Chemotaxis Dysfunction in Human Periodontitis
Van Dyke, T. E., Horoszewicz, H. U., Cianciola, L. J., & Genco, R. J. (1980) · Infection and Immunity · doi:10.1128/iai.27.1.124-132.1980 · Cited by 296
Human hyper-IgE syndrome: singular or plural?
Zhang, Q., Boisson, B., Béziat, V., Puel, A., & Casanova, J.-L. (2018) · Mammalian Genome · doi:10.1007/s00335-018-9767-2 · Cited by 67
Metadata
- Authors
- CLARK, R. A., ROOT, R. K., KIMBALL, H. R., & KIRKPATRICK, C. H.
- Venue
- Annals of Internal Medicine
- Publisher
- American College of Physicians
- Published
- 1973-04-01
- Volume
- 78
- Issue
- 4
- Pages
- 515-519
- ISSN
- 0003-4819 (ISSN-L)
- 1539-3704
- OpenAlex
- W2057852724
- Cited by
- 158
- References
- 0
- FWCI
- 3.93
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Defective Neutrophil Chemotaxis and Cellular Immunity in a Child with Recurrent Infections. https://app.cochat.ai/papers/10.7326/0003-4819-78-4-515
- The paper
- CLARK, R. A., ROOT, R. K., KIMBALL, H. R., & KIRKPATRICK, C. H. (1973). Defective Neutrophil Chemotaxis and Cellular Immunity in a Child with Recurrent Infections. Annals of Internal Medicine. https://doi.org/10.7326/0003-4819-78-4-515
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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