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Prognostic Factors in Cryptococcal Meningitis: A Study in 111 Cases
Abstract
Results of amphotericin B therapy were correlated with laboratory and clinical findings in 111 patients with cryptococcal meningitis. Compared with patients who were to be cured, patients who were to die during therapy more often had the following features on admission: lymphoreticular malignancy or corticosteroid therapy; cerebrospinal fluid with high opening pressure, a low glucose level, less than 20 leukocytes/mm3 and cryptococci seen in smear; cryptococci isolated from extraneural sites; and high titers of cryptococcal antigen in cerebrospinal fluid and serum. These last two features also characterized admission findings in the group of patients who were to be discharged with negative cultures after therapy but who later relapsed. Patients who were to relapse also had high, persistent posttreatment titers of cryptococcal antigen in serum or cerebrospinal fluid.
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Citations
Cited by
Cryptococcosis in the era of AIDS--100 years after the discovery of Cryptococcus neoformans
Mitchell, T. G., & Perfect, J. R. (1995) · Clinical Microbiology Reviews · doi:10.1128/cmr.8.4.515 · Cited by 1,213
Maziarz, E. K., & Perfect, J. R. (2016) · Infectious Disease Clinics of North America · doi:10.1016/j.idc.2015.10.006 · Cited by 698
ZUGER, A., LOUIE, E., HOLZMAN, R. S., SIMBERKOFF, M. S., & RAHAL, J. J. (1986) · Annals of Internal Medicine · doi:10.7326/0003-4819-104-2-234 · Cited by 522
Graybill, J. R., Sobel, J., Saag, M., van der Horst, C., Powderly, W., Cloud, G., Riser, L., Hamill, R., Dismukes, W., & NIAID Mycoses Study Group and AIDS Cooperative Treatment Groups (2000) · Clinical Infectious Diseases · doi:10.1086/313603 · Cited by 486
Dismukes, W. E., Cloud, G., Gallis, H. A., Kerkering, T. M., Medoff, G., Craven, P. C., Kaplowitz, L. G., Fisher, J. F., Gregg, C. R., Bowles, C. A., et al. (1987) · New England Journal of Medicine · doi:10.1056/nejm198708063170602 · Cited by 417
Metadata
- Authors
- DIAMOND, R. D., & BENNETT, J. E.
- Venue
- Annals of Internal Medicine
- Publisher
- American College of Physicians
- Published
- 1974-02-01
- Volume
- 80
- Issue
- 2
- Pages
- 176-181
- ISSN
- 0003-4819 (ISSN-L)
- 1539-3704
- OpenAlex
- W2065003627
- Cited by
- 605
- References
- 0
- FWCI
- 12.21
- Type
- journal article
- Language
- en
- Open access
- closed
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- DIAMOND, R. D., & BENNETT, J. E. (1974). Prognostic Factors in Cryptococcal Meningitis: A Study in 111 Cases. Annals of Internal Medicine. https://doi.org/10.7326/0003-4819-80-2-176
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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