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The Nephrotic Syndrome: A Complication of Massive Obesity
Abstract
Four patients with massive obesity and the nephrotic syndrome were studied. Congestive heart failure was not clinically apparent, and measured cardiac output was elevated; however, right atrial pressure and blood volume were increased. In each case the proteinuria decreased during dietary weight loss. Reductions in right atrial pressure and blood volume also coincided with remission in proteinuria. A mesangial glomerulopathy was present in two patients. We propose that the cause of the reversible proteinuria seen in these obese patients was renal venous hypertension.
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Citations
Cited by
Metabolic Syndrome and the Risk for Chronic Kidney Disease among Nondiabetic Adults
Kurella, M., Lo, J. C., & Chertow, G. M. (2005) · Journal of the American Society of Nephrology · doi:10.1681/asn.2005010106 · Cited by 709
Functional and Structural Changes in the Kidney in the Early Stages of Obesity
HENEGAR, J. R., BIGLER, S. A., HENEGAR, L. K., TYAGI, S. C., & HALL, J. E. (2001) · Journal of the American Society of Nephrology · doi:10.1681/asn.v1261211 · Cited by 549
Obesity and Obesity-Initiated Metabolic Syndrome: Mechanistic Links to Chronic Kidney Disease
Wahba, I. M., & Mak, R. H. (2007) · Clinical Journal of the American Society of Nephrology · doi:10.2215/cjn.04071206 · Cited by 513
Mechanisms of Obesity-Associated Cardiovascular and Renal Disease
Hall, J. E., Crook, E. D., Jones, D. W., Wofford, M. R., & Dubbert, P. M. (2002) · The American Journal of the Medical Sciences · doi:10.1097/00000441-200209000-00003 · Cited by 373
Focal and segmental glomerulosclerosis: Analogies to atherosclerosis
Diamond, J. R., & Karnovsky, M. J. (1988) · Kidney International · doi:10.1038/ki.1988.87 · Cited by 330
Metadata
- Authors
- WEISINGER, J. R., KEMPSON, R. L., ELDRIDGE, F. L., & SWENSON, R. S.
- Venue
- Annals of Internal Medicine
- Publisher
- American College of Physicians
- Published
- 1974-10-01
- Volume
- 81
- Issue
- 4
- Pages
- 440-447
- ISSN
- 0003-4819 (ISSN-L)
- 1539-3704
- OpenAlex
- W2084497043
- Cited by
- 318
- References
- 0
- FWCI
- 1.93
- Type
- journal article
- Language
- en
- Open access
- closed
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- WEISINGER, J. R., KEMPSON, R. L., ELDRIDGE, F. L., & SWENSON, R. S. (1974). The Nephrotic Syndrome: A Complication of Massive Obesity. Annals of Internal Medicine. https://doi.org/10.7326/0003-4819-81-4-440
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.