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Drug Spotlight Program: Systemic Corticosteroid Therapy: Pharmacology and Endocrinologic Considerations
Abstract
The biochemical and metabolic effects of the corticosteroids cannot be easily related to their desired anti-inflammatory and antiallergic therapeutic actions. Ordinarily, the corticosteroids have no place in the treatment of uncomplicated rheumatoid arthritis. Corticosteroid therapy is most important in those disorders requiring prolonged, high-dose and short-term intensive therapy. The complications of corticosteroid therapy can be largely reduced if the underlying disease permits alternate-day therapy. Suppression of the hypothalamic-pituitary-adrenal system is potentially the most hazardous complication of high-dose, prolonged corticosteroid therapy. This complication can be avoided by the institution of alternate-day therapy but it can become manifest up to 6 months after cessation of therapy.
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Research works printed but not linked: 13
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- 10.1016/0021-9681(70)90078-0 · DOI · Paper page
- 10.1001/jama.1953.03690160009004 · DOI · Paper page
- MELBY J, 1960, Acta Endocrinol, 35, 347
- MELBY J, 1959, J Clin Invest, 38, 1025
Cited by
Wound healing in glaucoma filtering surgery
Skuta, G. L., & Parrish, R. K. (1987) · Survey of Ophthalmology · doi:10.1016/0039-6257(87)90091-9 · Cited by 630
Schlaghecke, R., Kornely, E., Santen, R. T., & Ridderskamp, P. (1992) · New England Journal of Medicine · doi:10.1056/nejm199201233260403 · Cited by 381
Intestinal Calcium Absorption in Exogenous Hypercortisonism
Klein, R. G., Arnaud, S. B., Gallagher, J. C., Deluca, H. F., & Riggs, B. L. (1977) · Journal of Clinical Investigation · doi:10.1172/jci108762 · Cited by 362
Potency and duration of action of glucocorticoids
Meikle, A. W., & Tyler, F. H. (1977) · The American Journal of Medicine · doi:10.1016/0002-9343(77)90233-9 · Cited by 319
Suppression and recovery of adrenal response after short-term, high-dose glucocorticoid treatment
Henzen, C., Suter, A., Lerch, E., Urbinelli, R., Schorno, X. H., & Briner, V. A. (2000) · The Lancet · doi:10.1016/s0140-6736(99)06290-x · Cited by 290
Metadata
- Authors
- MELBY, J. C.
- Venue
- Annals of Internal Medicine
- Publisher
- American College of Physicians
- Published
- 1974-10-01
- Volume
- 81
- Issue
- 4
- Pages
- 505-512
- ISSN
- 0003-4819 (ISSN-L)
- 1539-3704
- OpenAlex
- W2085368017
- Cited by
- 222
- References
- 0
- FWCI
- 5.64
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.acpjournals.org/journal/aim/text-and-data-mining (tdm)
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- MELBY, J. C. (1974). Drug Spotlight Program: Systemic Corticosteroid Therapy: Pharmacology and Endocrinologic Considerations. Annals of Internal Medicine. https://doi.org/10.7326/0003-4819-81-4-505
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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