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Increased Risk of Lymphoma in Sicca Syndrome
Abstract
The risk of cancer was ascertained in 136 women with sicca syndrome followed at the National Institutes of Health (NIH). Seven patients developed non-Hodgkin's lymphoma from 6 months to 13 years after their first admission to NIH. This was 43.8 times (P less than 0.01) the incidence expected from the rates of cancer prevailing among women of the same age range in the general population during this time. In addition, three cases of Waldenström's macroglobulinemia occurred in this study group. Eight patients developed cancers other than lymphoma, similar to the number expected based on the rates prevailing in the general population. Patients with a history of parotid enlargement, splenomegaly, and lymphadenopahy had an increased risk of lymphoma. These clinical conditions did not appear to be early manifestations of undiagnosed lymphoma but rather seemed to identify a subgroup of patients with sicca syndrome with marked lymphoid reactivity, who had a particularly high risk of subsequently developing lymphoma.
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Cited by
Fox, R. I., Michelson, P., Casiano, C. A., Hayashi, J., & Stern, M. (2000) · Clinics in Dermatology · doi:10.1016/s0738-081x(00)00135-8 · Cited by 355
Sjögren Syndrome‐associated lymphomas: an update on pathogenesis and management
Nocturne, G., & Mariette, X. (2015) · British Journal of Haematology · doi:10.1111/bjh.13192 · Cited by 295
Pulmonary manifestations of Sjögren's syndrome
Hatron, P.-Y., Tillie-Leblond, I., Launay, D., Hachulla, E., Fauchais, A. L., & Wallaert, B. (2011) · La Presse Médicale · doi:10.1016/j.lpm.2010.11.002 · Cited by 73
Metadata
- Authors
- KASSAN, S. S., THOMAS, T. L., MOUTSOPOULOS, H. M., HOOVER, R., KIMBERLY, R. P., BUDMAN, D. R., COSTA, J., DECKER, J. L., & CHUSED, T. M.
- Venue
- Annals of Internal Medicine
- Publisher
- American College of Physicians
- Published
- 1978-12-01
- Volume
- 89
- Issue
- 6
- Pages
- 888-892
- ISSN
- 0003-4819 (ISSN-L)
- 1539-3704
- OpenAlex
- W2080894267
- Cited by
- 1,012
- References
- 0
- FWCI
- 9.12
- Type
- journal article
- Language
- en
- Open access
- closed
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- KASSAN, S. S., THOMAS, T. L., MOUTSOPOULOS, H. M., HOOVER, R., KIMBERLY, R. P., BUDMAN, D. R., COSTA, J., DECKER, J. L., & CHUSED, T. M. (1978). Increased Risk of Lymphoma in Sicca Syndrome. Annals of Internal Medicine. https://doi.org/10.7326/0003-4819-89-6-888
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