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Cited by 356

The DOI matches its Crossref record; 15 of the 15 references it cites were found in a registry or an index.

Oral Angiotensin-Converting Enzyme Inhibitor in Long-Term Treatment of Hypertensive Patients

BRUNNER, HANS R., GAVRAS, HARALAMBOS, WAEBER, BERNARD, KERSHAW, GLEN R., TURINI, GUSTAVE A., VUKOVICH, ROBERT A, McKINSTRY, DORIS N., GAVRAS, IRENE·1979·Annals of Internal Medicine
DOI 10.7326/0003-4819-90-1-19
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Abstract

The antihypertensive effect of the orally active angiotensin-converting enzyme inhibitor captopril (SQ 14225) was assessed in 22 hypertensive patients of whom 17 were followed for periods ranging from 1 to 7 months. Of these, eight had essential hypertension, eight had renovascular hypertension, and six had hypertension associated with chronic renal failure. Blood pressure decreased markedly in all patients, including those with low renin levels. Nevertheless, the magnitude of blood pressure reduction correlated with the base-line plasma renin activity (r = 0.58, P less than 0.01). Increasing the dose of captopril from 25 to 200 mg did not enhance the amplitude of the antihypertensive effect but did increase its duration. Patients' blood pressure remained well controlled and free of side-effects with a maximal daily dose of up to 200 mg by mouth twice daily. Despite the blood pressure reduction, sodium excretion tended to increase, probably because of reduced aldosterone secretion. There was no evidence of orthostatic hypotension, and no escape from the antihypertensive effect was observed. These results indicate that chronic inhibition of the angiotensin-converting enzyme with an orally active compound offers a new, efficient, and well-tolerated approach to the treatment of hypertension.

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Metadata

Authors
BRUNNER, H. R., GAVRAS, H., WAEBER, B., KERSHAW, G. R., TURINI, G. A., VUKOVICH, R. A., McKINSTRY, D. N., & GAVRAS, I.
Venue
Annals of Internal Medicine
Publisher
American College of Physicians
Published
1979-01-01
Volume
90
Issue
1
Pages
19-23
ISSN
  • 0003-4819 (ISSN-L)
  • 1539-3704
DOI
10.7326/0003-4819-90-1-19
OpenAlex
W2090095827
Cited by
356
References
15
FWCI
56.30
Type
journal article
Language
en
Open access
closed

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CoChat. (2026). Citation check: Oral Angiotensin-Converting Enzyme Inhibitor in Long-Term Treatment of Hypertensive Patients. https://app.cochat.ai/papers/10.7326/0003-4819-90-1-19
The paper
BRUNNER, H. R., GAVRAS, H., WAEBER, B., KERSHAW, G. R., TURINI, G. A., VUKOVICH, R. A., McKINSTRY, D. N., & GAVRAS, I. (1979). Oral Angiotensin-Converting Enzyme Inhibitor in Long-Term Treatment of Hypertensive Patients. Annals of Internal Medicine. https://doi.org/10.7326/0003-4819-90-1-19

Data sources

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.