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Cited by 94Parasites and Host InteractionsParasitic Diseases Research and TreatmentHelminth infection and control

The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.

Drugs Five Years Later: Mebendazole

KEYSTONE, JAY S., MURDOCH, JOHN K.·1979·Annals of Internal Medicine
DOI 10.7326/0003-4819-91-4-582
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Abstract

The broad-spectrum of activity and safety of mebendazole remain, after 5 years of clinical experience, unique features of this anthelmintic. Through microtubular destruction, mebendazole kills helminths by inhibiting glucose uptake into susceptible parasites. The drug's poor absorption does not appear to affect clinical efficacy except, perhaps, in the treatment of systemic helminth infections. Mebendazole is generally considered the drug of choice for trichuriasis and has therapeutic advantages over other anthelmintics in the treatment of enterobiasis and hookworm infections. Although mebendazole is an effective agent against ascariasis, there are preferable alternatives. Among its nonapproved uses, mebendazole shows great promise in the treatment of capillariasis and hydatid disease. Further investigation is needed to establish its role in the treatment of taeniasis, Hymenolepsis nana, strongyloidiasis, trichinosis, and Dipetalonema perstans. Undoubtedly, mebendazole will find its greatest value in the treatment of patients with multiple helminth infections.

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Research works printed but not linked: 38

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Metadata

Authors
KEYSTONE, J. S., & MURDOCH, J. K.
Affiliations
Toronto Canada
Corresponding author
KEYSTONE, JAY S.
Venue
Annals of Internal Medicine
Publisher
American College of Physicians
Published
1979-10-01
Volume
91
Issue
4
Pages
582-586
ISSN
  • 0003-4819 (ISSN-L)
  • 1539-3704
DOI
10.7326/0003-4819-91-4-582
OpenAlex
W2091382104
Cited by
94
References
1
Citations by year
2026: 2 · 2025: 5 · 2024: 1 · 2023: 4 · 2022: 6 · 2021: 2 · 2020: 3 · 2019: 1 · 2016: 1 · 2013: 2 · 2012: 1
FWCI
9.50
Type
journal article
Language
en
Open access
closed
Licence
www.acpjournals.org/journal/aim/text-and-data-mining (tdm)
Locations
  • Annals of Internal Medicine (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Immunology and Microbiology › Parasitology › Parasites and Host Interactions
  • Health Sciences › Medicine › Infectious Diseases › Parasitic Diseases Research and Treatment
  • Life Sciences › Immunology and Microbiology › Parasitology › Helminth infection and control
Keywords
mebendazole, anthelmintics, helminthiasis, trichuriasis, enterobiasis, hookworm infection, ascariasis, capillariasis, echinococcosis, taeniasis, Hymenolepis nana, strongyloidiasis, trichinellosis, microtubule inhibition, glucose uptake inhibition, drug absorption, drug safety
MeSH terms
Ascariasis, Benzimidazoles, Cestode Infections, Child, Child, Preschool, Helminthiasis, Hookworm Infections, Humans, Mebendazole, Nematode Infections, Oxyuriasis, Trichuriasis

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CoChat. (2026). Citation check: Drugs Five Years Later: Mebendazole. https://app.cochat.ai/papers/10.7326/0003-4819-91-4-582
The paper
KEYSTONE, J. S., & MURDOCH, J. K. (1979). Drugs Five Years Later: Mebendazole. Annals of Internal Medicine. https://doi.org/10.7326/0003-4819-91-4-582