The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
5-Fluorouracil, Doxorubicin, and Mitomycin (FAM) Combination Chemotherapy for Advanced Gastric Cancer
Abstract
Sixty-two patients with advanced measurable gastric cancer were treated with a combination chemotherapy program of 5-fluorouracil, doxorubicin, and mitomycin (FAM). Forty-two percent of patients achieved an objective partial response. The median duration of remission was 9 months and the median survival for responding patients, 12.5 months. The median survival for nonresponding patients was 3.5 months; all patients were dead by 8 months after initiation of therapy. The median survival of all 62 patients treated with FAM was 5.5 months. An analysis of possible prognostic variables including initial performance status, resectability of the primary gastric tumor, and histologic differentiation of the neoplasm failed to account for differences in patient response and survival. The FAM regimen was well tolerated, producing only moderate bone marrow suppression. These results show that patients with metastatic gastric cancer can be effectively palliated with FAM chemotherapy. The efficacy of this regimen should now be tested in patients with less advanced stages of this disease.
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Cites
Chemotherapy of Gastrointestinal Cancer
Moertel, C. G. (1978) · New England Journal of Medicine · doi:10.1056/nejm197811092991906 · Cited by 228
Cited by
Glimelius, B., Ekström, K., Hoffman, K., Graf, W., Sjödén, P.-O., Haglund, U., Svensson, C., Enander, L.-K., Linné, T., Sellsröm, H., et al. (1997) · Annals of Oncology · doi:10.1023/a:1008243606668 · Cited by 849
Orditura, M. (2014) · World Journal of Gastroenterology · doi:10.3748/wjg.v20.i7.1635 · Cited by 623
Phase II Study of S-1, a Novel Oral Derivative of 5-Fluorouracil, in Advanced Gastric Cancer
Koizumi, W., Kurihara, M., Nakano, S., & Hasegawa, K. (2000) · Oncology · doi:10.1159/000012099 · Cited by 440
Catalano, V., Labianca, R., Beretta, G. D., Gatta, G., de Braud, F., & Van Cutsem, E. (2009) · Critical Reviews in Oncology/Hematology · doi:10.1016/j.critrevonc.2009.01.004 · Cited by 365
Xu, J., Liu, D., Niu, H., Zhu, G., Xu, Y., Ye, D., Li, J., & Zhang, Q. (2017) · Journal of Experimental & Clinical Cancer Research · doi:10.1186/s13046-016-0487-8 · Cited by 283
Metadata
- Authors
- MACDONALD, J. S., SCHEIN, P. S., WOOLLEY, P. V., SMYTHE, T., UENO, W., HOTH, D., SMITH, F., BOIRON, M., GISSELBRECHT, C., BRUNET, R., & LAGARDE, C.
- Venue
- Annals of Internal Medicine
- Publisher
- American College of Physicians
- Published
- 1980-10-01
- Volume
- 93
- Issue
- 4
- Pages
- 533-536
- ISSN
- 0003-4819 (ISSN-L)
- 1539-3704
- OpenAlex
- W2111718148
- Cited by
- 351
- References
- 1
- FWCI
- 15.91
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: 5-Fluorouracil, Doxorubicin, and Mitomycin (FAM) Combination Chemotherapy for Advanced Gastric Cancer. https://app.cochat.ai/papers/10.7326/0003-4819-93-4-533
- The paper
- MACDONALD, J. S., SCHEIN, P. S., WOOLLEY, P. V., SMYTHE, T., UENO, W., HOTH, D., SMITH, F., BOIRON, M., GISSELBRECHT, C., BRUNET, R., & LAGARDE, C. (1980). 5-Fluorouracil, Doxorubicin, and Mitomycin (FAM) Combination Chemotherapy for Advanced Gastric Cancer. Annals of Internal Medicine. https://doi.org/10.7326/0003-4819-93-4-533
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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