The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Recombinant Leukocyte A Interferon: Pharmacokinetics, Single-Dose Tolerance, and Biologic Effects in Cancer Patients
Abstract
Sixteen patients with advanced cancer were treated with recombinant-DNA-produced pure leukocyte A interferon (IFLrA) intramuscularly in doses ranging from 3 to 198 X 10(6) units. with interval periods of 72 to 96 hours between doses. At the two lowest doses of 3 and 9 million units, there was a cross-over evaluation between IFLrA and partially pure leukocyte interferon (IFN-C) produced from human cells. THe maximum observed serum concentration of IFLrA measured by enzyme immunoassay and bioassay increased with increasing doses. The mean serum concentrations of IFLrA and IFN-C were similar. Clinical effects produced by IFLrA and IFN-C were similar, including fever, chills, myalgias, headache fatigue, and reversible leukopenia and granulocytopenia. Eight patients had transient and mild numbness of the hands or feet, or both. Three patients developed low titers of antibody to IFLrA, Seven of 16 patients showed objective evidence of tumor regression during the study.
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Cites
Virus interference. I. the interferon
Isaacs, A., & Lindenmann, J. (1957) · Proceedings of the Royal Society of London. Series B - Biological Sciences · doi:10.1098/rspb.1957.0048 · Cited by 3,451
Cited by
Major Depression and Activation of The Inflammatory Response System
Maes, M. (1999) · Advances in Experimental Medicine and Biology · doi:10.1007/978-0-585-37970-8_2 · Cited by 617
Psychiatric Complications of Long-term Interferon Alfa Therapy
Renault, P. F. (1987) · Archives of Internal Medicine · doi:10.1001/archinte.1987.00370090055011 · Cited by 413
Zoumbos, N. C., Gascon, P., Djeu, J. Y., & Young, N. S. (1985) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.82.1.188 · Cited by 330
Clinical investigation of human alpha interferon in chronic myelogenous leukemia
Talpaz, M., Kantarjian, H., McCredie, K., Keating, M., Trujillo, J., & Gutterman, J. (1987) · Blood · doi:10.1182/blood.v69.5.1280.1280 · Cited by 328
Self-citationAntitumor activity of recombinant-derived interferon alpha in metastatic renal cell carcinoma.
Quesada, J. R., Rios, A., Swanson, D., Trown, P., & Gutterman, J. U. (1985) · Journal of Clinical Oncology · doi:10.1200/jco.1985.3.11.1522 · Cited by 272
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Metadata
- Authors
- GUTTERMAN, J. U., FINE, S., QUESADA, J., HORNING, S. J., LEVINE, J. F., ALEXANIAN, R., BERNHARDT, L., KRAMER, M., SPIEGEL, H., COLBURN, W., TROWN, P., MERIGAN, T., & DZIEWANOWSKI, Z.
- Venue
- Annals of Internal Medicine
- Publisher
- American College of Physicians
- Published
- 1982-05-01
- Volume
- 96
- Issue
- 5
- Pages
- 549-556
- ISSN
- 0003-4819 (ISSN-L)
- 1539-3704
- OpenAlex
- W2128394628
- Cited by
- 377
- References
- 1
- FWCI
- 22.97
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Recombinant Leukocyte A Interferon: Pharmacokinetics, Single-Dose Tolerance, and Biologic Effects in Cancer Patients. https://app.cochat.ai/papers/10.7326/0003-4819-96-5-549
- The paper
- GUTTERMAN, J. U., FINE, S., QUESADA, J., HORNING, S. J., LEVINE, J. F., ALEXANIAN, R., BERNHARDT, L., KRAMER, M., SPIEGEL, H., COLBURN, W., TROWN, P., MERIGAN, T., & DZIEWANOWSKI, Z. (1982). Recombinant Leukocyte A Interferon: Pharmacokinetics, Single-Dose Tolerance, and Biologic Effects in Cancer Patients. Annals of Internal Medicine. https://doi.org/10.7326/0003-4819-96-5-549
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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