The DOI matches its Crossref record; 35 of the 35 references it cites were found in a registry or an index.
Gastroesophageal Reflux: Pathogenesis, Diagnosis, and Therapy
Abstract
In recent years, considerable new information has become available on the pathogenesis, diagnosis and therapy of gastroesophageal reflux. Gastric contents, mucosal resistance, esophageal acid clearance, and gastric emptying are now recognized, along with incompetency of the lower esophageal sphincter, as contributing factors to gastroesophageal reflux disease. The potential tests for reflux are reviewed and the diagnostic accuracy of each is evaluated. A diagnostic approach to the patient with reflux symptoms is outlined that considers the sensitivity and specificity of these various tests as well as their availability to the generalist and gastrointestinal specialist. Finally, an overview of the current therapy for reflux disease summarizes the controlled studies in the medical literature.
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Citations
Cites
Lf, J., & DeMeester, T. R. (1974) · PubMed · Cited by 1,122
Mechanism of gastroesophageal reflux in recumbent asymptomatic human subjects.
Dent, J., Dodds, W. J., Friedman, R. H., Sekiguchi, T., Hogan, W. J., Arndorfer, R. C., & Petrie, D. J. (1980) · Journal of Clinical Investigation · doi:10.1172/jci109667 · Cited by 927
Symptomatic gastroesophageal reflux: Incidence and precipitating factors
Nebel, O. T., Fornes, M. F., & Castell, D. O. (1976) · The American Journal of Digestive Diseases · doi:10.1007/bf01071906 · Cited by 874
Self-citationHistological Consequences of Gastroesophageal Reflux in Man
Ismail-Beigi, F., Horton, P. F., & Pope, C. E. (1970) · Gastroenterology · doi:10.1016/s0016-5085(70)80004-x · Cited by 778
Patterns of Gastroesophageal Reflux in Health and Disease
DEMEESTER, T. R., JOHNSON, L. F., JOSEPH, G. J., TOSCANO, M. S., HALL, A. W., & SKINNER, D. B. (1976) · Annals of Surgery · doi:10.1097/00000658-197610000-00009 · Cited by 721
Technique, indications, and clinical use of 24 hour esophageal pH monitoring
DeMeester, T. R., Wang, C.-I., Wernly, J. A., Pellegrini, C. A., Little, A. G., Klementschitsch, P., Bermudez, G. A., Johnson, L. F., & Skinner, D. B. (1980) · Journal of Thoracic and Cardiovascular Surgery · doi:10.1016/s0022-5223(19)37879-1 · Cited by 528
Endoscopic Complications: Results of the 1974 American Society for Gastrointestinal Endoscopy Survey
Silvis, S. E. (1976) · JAMA · doi:10.1001/jama.1976.03260350032023 · Cited by 488
Gastric emptying in patients with gastroesophageal reflux
Mccallum, R. W., Berkowitz, D. M., & Lerner, E. (1981) · Gastroenterology · doi:10.1016/0016-5085(81)90716-2 · Cited by 403
Does Hiatus Hernia Affect Competence of the Gastroesophageal Sphincter?
Cohen, S., & Harris, L. D. (1971) · New England Journal of Medicine · doi:10.1056/nejm197105132841902 · Cited by 380
Pathogenesis of Reflux Esophagitis
Dodds, W. J., Hogan, W. J., Helm, J. F., & Dent, J. (1981) · Gastroenterology · doi:10.1016/s0016-5085(81)80072-8 · Cited by 329
Cited by
Guidelines for the Diagnosis and Management of Gastroesophageal Reflux Disease
Katz, P. O., Gerson, L. B., & Vela, M. F. (2013) · American Journal of Gastroenterology · doi:10.1038/ajg.2012.444 · Cited by 1,767
Koufman, J. A. (1991) · The Laryngoscope · doi:10.1002/lary.1991.101.s53.1 · Cited by 1,647
Symptoms in gastro-oesophageal reflux disease
Klauser, A. G., Schindlbeck, N. E., & Müller-Lissner, S. A. (1990) · The Lancet · doi:10.1016/0140-6736(90)90287-f · Cited by 745
Risk factors associated with symptoms of gastroesophageal reflux
Locke, G. R., Talley, N. J., Fett, S. L., Zinsmeister, A. R., & Melton, L. J. (1999) · The American Journal of Medicine · doi:10.1016/s0002-9343(99)00121-7 · Cited by 522
Fass, R., Fennerty, M. B., Ofman, J. J., Gralnek, I. M., Johnson, C., Camargo, E., & Sampliner, R. E. (1998) · Gastroenterology · doi:10.1016/s0016-5085(98)70363-4 · Cited by 396
Metadata
- Authors
- RICHTER, J. E., & CASTELL, D. O.
- Venue
- Annals of Internal Medicine
- Publisher
- American College of Physicians
- Published
- 1982-07-01
- Volume
- 97
- Issue
- 1
- Pages
- 93-103
- ISSN
- 0003-4819 (ISSN-L)
- 1539-3704
- OpenAlex
- W1992109982
- Cited by
- 393
- References
- 35
- FWCI
- 16.10
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Gastroesophageal Reflux: Pathogenesis, Diagnosis, and Therapy. https://app.cochat.ai/papers/10.7326/0003-4819-97-1-93
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- RICHTER, J. E., & CASTELL, D. O. (1982). Gastroesophageal Reflux: Pathogenesis, Diagnosis, and Therapy. Annals of Internal Medicine. https://doi.org/10.7326/0003-4819-97-1-93
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
