The DOI matches its Crossref record.
D-Penicillamine Therapy in Progressive Systemic Sclerosis (Scleroderma): A Retrospective Analysis
Abstract
In a retrospective study on progressive systemic sclerosis, we compared 73 patients who had received D-penicillamine therapy for a minimum of 6 consecutive months with 45 patients who had not received this drug. All patients had diffuse sclerodermatous skin changes and early disease (less than 3-years duration). D-Penicillamine was prescribed for an average of 24 months (range, 6 to 68 months) with a maximum daily dose of 500 to 1500 mg (median, 750 mg). During a mean follow-up interval of 38 months, the degree and extent of skin thickness, determined on physical examination, decreased considerably more in the patients treated with D-penicillamine than in patients in the comparison group (p = 0.07). The rate of new visceral organ involvement was reduced in patients treated with D-penicillamine, especially for the kidney (p = 0.01). Patients treated with D-penicillamine had a greater 5-year cumulative survival rate (88% versus 66%, p less than 0.05). Therapy with colchicine (23 patients) or immunosuppressive agents (26 patients) was not associated with these improvements.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cited by
Steen, V., & Medsger, T. A. (2003) · Arthritis & Rheumatism · doi:10.1002/art.10775 · Cited by 494
Self-citationFelson, D. T., Anderson, J. J., Lange, M. L. M., Wells, G., & LaValley, M. P. (1998) · Arthritis & Rheumatism · doi:10.1002/1529-0131(199809)41:9 · Cited by 474
Steen, V. D., Costantino, J. P., Shapiro, A. P., & Medsger, T. A. (1990) · Annals of Internal Medicine · doi:10.7326/0003-4819-113-5-352 · Cited by 441
Self-citationVAN DEN HOOGEN, F. H. J., BOERBOOMS, A. M. T., SWAAK, A. J. G., RASKER, J. J., VAN LIER, H. J. J., & VAN DE PUTTE, L. B. A. (1996) · Rheumatology · doi:10.1093/rheumatology/35.4.364 · Cited by 355
Metadata
- Authors
- STEEN, V. D., MEDSGER, T. A., & RODNAN, G. P.
- Venue
- Annals of Internal Medicine
- Publisher
- American College of Physicians
- Published
- 1982-11-01
- Volume
- 97
- Issue
- 5
- Pages
- 652-659
- ISSN
- 0003-4819 (ISSN-L)
- 1539-3704
- OpenAlex
- W2003583490
- Cited by
- 322
- References
- 0
- FWCI
- 8.19
- Type
- journal article
- Language
- en
- Open access
- closed
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: D-Penicillamine Therapy in Progressive Systemic Sclerosis (Scleroderma): A Retrospective Analysis. https://app.cochat.ai/papers/10.7326/0003-4819-97-5-652
- The paper
- STEEN, V. D., MEDSGER, T. A., & RODNAN, G. P. (1982). D-Penicillamine Therapy in Progressive Systemic Sclerosis (Scleroderma): A Retrospective Analysis. Annals of Internal Medicine. https://doi.org/10.7326/0003-4819-97-5-652
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
