The DOI matches its Crossref record.
Predictive Factors in Chronic Graft-Versus-Host Disease in Patients with Aplastic Anemia Treated by Marrow Transplantation from HLA-Identical Siblings
Abstract
One hundred ten of 175 patients with aplastic anemia conditioned by cyclophosphamide had sustained engraftment of marrow from human leukocyte antigen (HLA)-identical siblings and lived for more than 6 months. Forty-nine of the 110 patients developed chronic graft-versus-host disease between 85 and 464 days. Ninety-seven patients are alive from 1.4 to 11 years after engraftment; 13 died between 208 and 726 days. Twenty of the 36 surviving patients with chronic graft-versus-host disease have Karnofsky performance scores of 100%, 7 of 90%, 5 of 80%, 1 of 70%, 2 of 60%, and 1 of 40%. Our analysis, using a binary logistic regression model, identified three factors predicting chronic graft-versus-host disease: moderate to severe acute graft-versus-host disease with an estimated relative risk of 11.65; increasing patient age; and the use of viable donor buffy coat cells in addition to the marrow to prevent graft rejection. The last two factors were significant only in patients without acute graft-versus-host disease.
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Cited by
Prentice, H. G., Janossy, G., Price-Jones, L., Trejdosiewicz, L. K., Panjwani, D., Graphakos, S., Ivory, K., Blacklock, H. A., Gilmore, M. J. M. L., Tidman, N., et al. (1984) · The Lancet · doi:10.1016/s0140-6736(84)92848-4 · Cited by 355
Locatelli, F., Kabbara, N., Ruggeri, A., Ghavamzadeh, A., Roberts, I., Li, C. K., Bernaudin, F., Vermylen, C., Dalle, J.-H., Stein, J., et al. (2013) · Blood · doi:10.1182/blood-2013-03-489112 · Cited by 244
Metadata
- Authors
- STORB, R., PRENTICE, R. L., SULLIVAN, K. M., SHULMAN, H. M., DEEG, H. J., DONEY, K. C., BUCKNER, C. D., CLIFT, R. A., WITHERSPOON, R. P., APPELBAUM, F. A., SANDERS, J. E., STEWART, P. S., & THOMAS, E. D.
- Venue
- Annals of Internal Medicine
- Publisher
- American College of Physicians
- Published
- 1983-04-01
- Volume
- 98
- Issue
- 4
- Pages
- 461-466
- ISSN
- 0003-4819 (ISSN-L)
- 1539-3704
- OpenAlex
- W2160808195
- Cited by
- 281
- References
- 0
- FWCI
- 6.83
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Predictive Factors in Chronic Graft-Versus-Host Disease in Patients with Aplastic Anemia Treated by Marrow Transplantation from HLA-Identical Siblings. https://app.cochat.ai/papers/10.7326/0003-4819-98-4-461
- The paper
- STORB, R., PRENTICE, R. L., SULLIVAN, K. M., SHULMAN, H. M., DEEG, H. J., DONEY, K. C., BUCKNER, C. D., CLIFT, R. A., WITHERSPOON, R. P., APPELBAUM, F. A., SANDERS, J. E., STEWART, P. S., & THOMAS, E. D. (1983). Predictive Factors in Chronic Graft-Versus-Host Disease in Patients with Aplastic Anemia Treated by Marrow Transplantation from HLA-Identical Siblings. Annals of Internal Medicine. https://doi.org/10.7326/0003-4819-98-4-461
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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