The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Neurologic Abnormalities of Lyme Disease: Successful Treatment with High-Dose Intravenous Penicillin
Abstract
Twelve patients were treated with high-dose intravenous penicillin for neurologic abnormalities of Lyme disease. Headache, stiff neck, and radicular pain usually began to subside by the second day of therapy and were often gone by 7 to 10 days. Five of the 12 patients continued to have intermittent mild headache for several more weeks, but no patient relapsed after therapy was stopped. Compared to 15 previous patients treated with prednisone alone, the duration of meningitic syndrome was significantly shorter in those given penicillin (mean duration, 1 versus 29 weeks, p less than 0.000001). However, in both groups, a mean of 7 to 8 weeks was required for complete recovery of motor deficits. Despite antibiotic therapy, 3 of the 12 patients treated with penicillin continued to have frequent arthralgias, musculoskeletal pain, and fatigue. We conclude that high-dose intravenous penicillin is effective therapy for neurologic abnormalities of Lyme disease.
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Citations
Cites
ERYTHEMA CHRONICUM MIGRANS AND LYME ARTHRITIS: EPIDEMIOLOGIC EVIDENCE FOR A TICK VECTOR1
STEERE, A. C., BRODERICK, T. F., & MALAWISTA, S. E. (1978) · American Journal of Epidemiology · doi:10.1093/oxfordjournals.aje.a112625 · Cited by 310
Self-citationCerebrospinal Fluid Penicillin Levels During Therapy for Latent Syphilis
Ducas, J. (1981) · JAMA: The Journal of the American Medical Association · doi:10.1001/jama.1981.03320220033020 · Cited by 48
Cited by
Microbiota regulation of the mammalian gut-brain axis
Burokas, A., Moloney, R. D., Dinan, T. G., & Cryan, J. F. (2015) · Advances in applied microbiology · doi:10.1016/bs.aambs.2015.02.001 · Cited by 300
Lyme neuroborreliosis—epidemiology, diagnosis and management
Koedel, U., Fingerle, V., & Pfister, H.-W. (2015) · Nature Reviews Neurology · doi:10.1038/nrneurol.2015.121 · Cited by 284
Karlsson, M., Hammers, S., Nilsson-Ehle, I., Malmborg, A. S., & Wretlind, B. (1996) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.40.5.1104 · Cited by 76
Metadata
- Authors
- STEERE, A. C., ANDREW R., P., & MALAWISTA, S. E.
- Venue
- Annals of Internal Medicine
- Publisher
- American College of Physicians
- Published
- 1983-12-01
- Volume
- 99
- Issue
- 6
- Pages
- 767-772
- ISSN
- 0003-4819 (ISSN-L)
- 1539-3704
- OpenAlex
- W2081738938
- Cited by
- 277
- References
- 2
- FWCI
- 19.74
- Type
- journal article
- Language
- en
- Open access
- closed
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- STEERE, A. C., ANDREW R., P., & MALAWISTA, S. E. (1983). Neurologic Abnormalities of Lyme Disease: Successful Treatment with High-Dose Intravenous Penicillin. Annals of Internal Medicine. https://doi.org/10.7326/0003-4819-99-6-767
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
