The DOI matches its Crossref record; 32 of the 32 references it cites were found in a registry or an index.
Metabolically Healthy Obesity and Development of Chronic Kidney Disease: A Cohort Study
Abstract
BACKGROUND: The risk for chronic kidney disease (CKD) among obese persons without obesity-related metabolic abnormalities, called metabolically healthy obesity, is largely unexplored. OBJECTIVE: To investigate the risk for incident CKD across categories of body mass index in a large cohort of metabolically healthy men and women. DESIGN: Prospective cohort study. SETTING: Kangbuk Samsung Health Study, Kangbuk Samsung Hospital, Seoul, South Korea. PARTICIPANTS: 62 249 metabolically healthy, young and middle-aged men and women without CKD or proteinuria at baseline. MEASUREMENTS: Metabolic health was defined as a homeostasis model assessment of insulin resistance less than 2.5 and absence of any component of the metabolic syndrome. Underweight, normal weight, overweight, and obesity were defined as a body mass index less than 18.5 kg/m2, 18.5 to 22.9 kg/m2, 23 to 24.9 kg/m2, and 25 kg/m2 or greater, respectively. The outcome was incident CKD, defined as an estimated glomerular filtration rate less than 60 mL/min/1.73 m2. RESULTS: During 369 088 person-years of follow-up, 906 incident CKD cases were identified. The multivariable-adjusted differences in 5-year cumulative incidence of CKD in underweight, overweight, and obese participants compared with normal-weight participants were -4.0 (95% CI, -7.8 to -0.3), 3.5 (CI, 0.9 to 6.1), and 6.7 (CI, 3.0 to 10.4) cases per 1000 persons, respectively. These associations were consistently seen in all clinically relevant subgroups. LIMITATION: Chronic kidney disease was identified by a single measurement at each visit. CONCLUSION: Overweight and obesity are associated with an increased incidence of CKD in metabolically healthy young and middle-aged participants. These findings show that metabolically healthy obesity is not a harmless condition and that the obese phenotype, regardless of metabolic abnormalities, can adversely affect renal function. PRIMARY FUNDING SOURCE: None.
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Garofalo, C., Borrelli, S., Minutolo, R., Chiodini, P., De Nicola, L., & Conte, G. (2017) · Kidney International · doi:10.1016/j.kint.2016.12.013 · Cited by 363
Obesity and chronic kidney disease
Jiang, Z., Wang, Y., Zhao, X., Cui, H., Han, M., Ren, X., Gang, X., & Wang, G. (2023) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00179.2022 · Cited by 267
Ruggenenti, P., Abbate, M., Ruggiero, B., Rota, S., Trillini, M., Aparicio, C., Parvanova, A., Petrov Iliev, I., Pisanu, G., Perna, A., et al. (2017) · Diabetes · doi:10.2337/db16-0607 · Cited by 95
Off-label drugs for weight management
Hendricks, E. (2017) · Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy · doi:10.2147/dmso.s95299 · Cited by 82
Nichols, G. A., Horberg, M., Koebnick, C., Young, D. R., Waitzfelder, B., Sherwood, N. E., Daley, M. F., & Ferrara, A. (2017) · Preventing Chronic Disease · doi:10.5888/pcd14.160438 · Cited by 36
Metadata
- Authors
- Chang, Y., Ryu, S., Choi, Y., Zhang, Y., Cho, J., Kwon, M.-J., Hyun, Y. Y., Lee, K.-B., Kim, H., Jung, H.-S., Yun, K. E., Ahn, J., Rampal, S., Zhao, D., Suh, B.-S., Chung, E. C., Shin, H., Pastor-Barriuso, R., & Guallar, E.
- Venue
- Annals of Internal Medicine
- Publisher
- American College of Physicians
- Published
- 2016-03-01
- Volume
- 164
- Issue
- 5
- Pages
- 305-312
- ISSN
- 0003-4819 (ISSN-L)
- 1539-3704
- OpenAlex
- W2290487107
- Cited by
- 283
- References
- 32
- FWCI
- 32.62
- Type
- journal article
- Language
- en
- Open access
- closed
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- Chang, Y., Ryu, S., Choi, Y., Zhang, Y., Cho, J., Kwon, M.-J., Hyun, Y. Y., Lee, K.-B., Kim, H., Jung, H.-S., Yun, K. E., Ahn, J., Rampal, S., Zhao, D., Suh, B.-S., Chung, E. C., Shin, H., Pastor-Barriuso, R., & Guallar, E. (2016). Metabolically Healthy Obesity and Development of Chronic Kidney Disease: A Cohort Study. Annals of Internal Medicine. https://doi.org/10.7326/m15-1323
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