The Effects of Cannabis Among Adults With Chronic Pain and an Overview of General Harms: A Systematic Review

Nugent, Shannon M., Morasco, Benjamin J., O'Neil, Maya E., Freeman, Michele, Low, Allison, Kondo, Karli, Elven, Camille, Zakher, Bernadette +3 more·2017·Annals of Internal Medicine
DOI 10.7326/m17-0155

Cited by (301)

Items 201–300 of 301

  1. Medical marijuana in the United States: Historical perspectives, legal considerations, and professional obligations of the pharmacist
    James Scott Wheeler, Tracy M. Hagemann · 2018 · JACCP JOURNAL OF THE AMERICAN COLLEGE OF CLINICAL PHARMACY
  2. A Quality-of-Life Evaluation Study Assessing Health-Related Quality of Life in Patients Receiving Medicinal Cannabis (the QUEST Initiative): Protocol for a Longitudinal Observational Study
    Margaret-Ann Tait, Daniel S J Costa, Rachel Campbell, Richard Norman, Stephan Alexander Schug, Claudia Rutherford · 2021 · JMIR Research Protocols
  3. Exploring The Contours: Navigating Cannabis Use Among Older Adults
    Yoo Mee Shin, Mohamad Moussa, Joyce A Akwe · 2024 · Journal of Brown Hospital Medicine
  4. Discontinuation rates and predictors of Medical Cannabis cessation for chronic musculoskeletal pain
    Mohammad Khak, Sina Ramtin, Juliet Chung, Asif M. Ilyas, Ari C. Greis · 2025 · PLoS ONE
  5. Opioid reduction in patients with chronic non-cancer pain undergoing treatment with medicinal cannabis
    Philip M. Finch, Leanne M. Price, Theresa M Price, Michael J. Kent, Peter D. Drummond · 2025 · Pain Management
  6. The therapeutic use of cannabis in South Africa: panacea or scourge?
    W.J. Maule · 2022 · Journal of Medical Laboratory Science & Technology of South Africa
  7. Dispensary Staff Perceptions About the Benefits, Risks, and Safety of Cannabis for Medical Purposes
    Hailey W. Bulls, Andrew D. Althouse, Robert Feldman, Julia Hope Arnsten, Jane M. Liebschutz, Shannon M. Nugent, Steven R. Orris, Rebecca Rohac, Deepika E. Slawek, Joanna L. Starrels et al. · 2023 · Substance Abuse
  8. Regulatory challenges on cannabis
    Kumar Gautam Rohit, Pandey Ruchi, Dubey Itishree, Kushwaha Sapana · 2024 · Elsevier eBooks
  9. Knowledge domain and emerging trends in the rupture risk of intracranial aneurysms research from 2004 to 2023
    Junchen Chen, Cheng Luo, Yong Li, Dianhui Tan · 2024 · World Journal of Clinical Cases
  10. Cannabis use and illicit opioid cessation among people who use drugs living with chronic pain
    Chenai Kitchen, Maria Eugenia Socias, Eric C. Sayre, Kanna Hayashi, Kora DeBeck, M‐J Milloy, Thomas H Kerr, Hudson Reddon · 2025 · Drug and Alcohol Review
  11. Marijuana Use in Older Adults: Employing a Risk Reduction Strategy
    Zachary A. Marcum, Sarah Tu, Carol A. Gotway Crawford, Lianne A. Hirano · 2019 · Annals of Pharmacotherapy
  12. Pain and Healthy Aging
    Fabio Guerriero, M. Carrington Reid · 2019 · Springer eBooks
  13. Can Pain Management be Safely Optimized in Older Adults?
    Christina Y. Chen, Brandon P. Verdoorn · 2020 · Mayo Clinic Proceedings
  14. Medical Marijuana for Chronic Pain
    Bonnie Huang Hall · 2020 · Springer eBooks
  15. Kentucky KASPER and Controlled Substance Prescribing
    Alexander M. Dydyk, Daniel C. Sizemore, William Spafford Smock, Scott C. Dulebohn, Burdett R. Porter · 2021 · StatPearls
  16. EXPLORING THE EFFICACY AND SAFETY OF CANNABIS IN THE MANAGEMENT OF FIBROMYALGIA
    Amol Sagdeo, Ayman Askari, Patrick Ball, Hana Morrissey · 2022 · International Journal of Current Pharmaceutical Research
  17. Does the legalisation of cannabis for medicinal use impact private health insurer prescription drug expenditures?
    Amanda C. Cook, Eleanor Tice Sirmans, Brenda P. Wells · 2023 · The Geneva Papers on Risk and Insurance Issues and Practice
  18. Psychoactive drugs
    F.F. Youssef, Jarosław Widelski, W.A. Kukula-Koch · 2023 · Elsevier eBooks
  19. Correlates of cannabis use in a sample of mental health treatment-seeking Canadian armed forces members and veterans
    Kate St. Cyr, Anthony Nazarov, Tri Le, Maede Sadat Nouri, Priyonto Saha, Callista A. Forchuk, Vanessa Soares, Sonya G. Wanklyn, Brian M. Bird, Brent D. Davis et al. · 2023 · BMC Psychiatry
  20. Evaluation of pre-hospital cannabis exposure and hospital opioid utilization in a trauma population: A retrospective cohort
    Alexander J. Chang, Ali F. Mallat, Marc J Edwards, Joseph N. Gabra, Michaelia D. Cucci · 2023 · Injury
  21. Oncology: What You May Have Missed in 2023
    Courtney H. Coschi, Lorin Dodbiba, DuPont Guerry · 2024 · Annals of Internal Medicine
  22. Cannabis for Chronic Pain: We Simply Don’t Know
    Shannon M. Nugent, Devan L. Kansagara · 2019 · Pain Medicine
  23. An overview of the adverse effects of cannabis use for Canadian physicians.
    H. Leduc‐Pessah, Samuel K. Jensen, C. Newell · 2019 · Clinical and investigative medicine. Medecine clinique et experimentale
  24. West Virginia Opioid Prescribing For Chronic Pain While Avoiding Drug Diversion
    Alexander M. Dydyk, Daniel C. Sizemore, Lindsay A. Trachsel, Till Conermann, Burdett R. Porter · 2021 · StatPearls
  25. Living Systematic Review on Cannabis and Other Plant-Based Treatments for Chronic Pain: Surveillance Report 4
    Roger Chou, Jesse Wagner, Azrah Y. Ahmed, Benjamin J. Morasco, Devan L. Kansagara, Shelley Selph, Rebecca S. Holmes, Rongwei Fu · 2022
  26. Association Between Cannabis Use and Neuropsychiatric Disorders: A Two-sample Mendelian Randomization Study
    Wei Guo, Lin Dong, Qingxing Lu, Mengtong Xie, Yuqi Yang, Yanchi Zhang, Xiaoyu Lu, Qiong Yu · 2025 · ALPHA PSYCHIATRY
  27. The Present and Future of Pain Management in Patients With Chronic Kidney Disease: A Narrative Review
    Igor Wilderman, Francesca Sarzetto, Budvin Wijetillake, Sydney Verdun · 2025 · Cureus
  28. Concomitant Cannabis Misuse and Associations with Depression, Pain and Substance Misuse among Patients Prescribed Opioids
    M. Aryana Bryan, Elizabeth M. Charron, Omolola A. Adeoye‐Olatunde, Jennifer L. Brown, Udi E. Ghitza, Theresa M. Winhusen, Gerald Cochran · 2021 · Pharmacy
  29. Associations between adult cannabis use and chronic health conditions in a nationally representative sample of the United States
    Anas Khurshid Nabil, Adam E. Barry, Cassidy R. LoParco, Matthew E. Rossheim · 2023 · Journal of Substance Use
  30. Patient Experiences with the Use of Medicinal Cannabis in the Netherlands: A Cohort-Event Monitoring Study
    Corine Ekhart, Suzy Schipper, Marco J. van de Velde, Leàn Rolfes, Agnes C Kant · 2023 · Integrative Medicine Reports
  31. Empleo empírico de cannabis para control del dolor crónico de origen musculoesquelético
    Uriah Guevara‐López, Jesús Elizarrarás-Rivas, Sergio Alberto Ramirez-Garcia, Vladimir Hernández-Sosa, Adalberto De Hoyos-Bermea, Jesús Ángel González-Sánchez, Rodolfo Federico Viguri-Castellanos · 2024 · Revista Mexicana de Anestesiología
  32. Impact of Tobacco, Marijuana, and Alcohol Use on Overall Survival in Recurrent Metastatic Head and Neck Cancer Patients Treated With Immune Checkpoint Inhibitors
    Mohammad Bilal Alsavaf, Majd Issa, Brett G. Klamer, Marium Husain, Khaled Nabil Dibs, Xueliang Jeff Pan, J.C. Grecula, Matthew Owen Old, David Joseph Konieczkowski, Darrion Mitchell et al. · 2024 · Asia-Pacific Journal of Clinical Oncology
  33. ADHD Symptoms and Medical Cannabis Use Among Adults With Chronic Pain
    David C. Saunders, Deepika E. Slawek, Chenshu Zhang, Nancy Sohler, Chinazo O. Cunningham, Haruka Minami, Joanna L. Starrels, Julia Hope Arnsten, FRANCES RUDNICK LEVIN · 2025 · Journal of Attention Disorders
  34. Cannabis in Pain
    Kenneth P. Finn · 2020 · Elsevier eBooks
  35. Understanding Delaware Prescribing and Distribution Of Controlled Substances
    Alexander M. Dydyk, Daniel C. Sizemore, Debra M. Ravert, Burdett R. Porter · 2021 · StatPearls
  36. Should You Recommend Cannabinoids for This Patient With Painful Neuropathy?
    Gerald W. Smetana, Jeanette M. Tetrault, Kevin P. Hill, Risa Beth Burns · 2021 · Annals of Internal Medicine
  37. Considerations for the Intersection of Sedation and Marijuana
    Brian E. McGeeney, Rachael Rzasa Lynn · 2021 · Springer eBooks
  38. Tennessee Controlled Substance Prescribing For Acute and Chronic Pain
    Alexander M. Dydyk, Daniel C. Sizemore, Lindsay A. Trachsel, Scott C. Dulebohn, Burdett R. Porter · 2021 · StatPearls
  39. Living Systematic Review on Cannabis and Other Plant-Based Treatments for Chronic Pain: May 2021 Update
    Marian S. McDonagh, Jesse Wagner, Azrah Y. Ahmed, Benjamin J. Morasco, Devan L. Kansagara, Roger Chou · 2021
  40. The Demand for Medical Cannabis Education
    Christina Le-Short, Samer Narouze · 2021 · Springer eBooks
  41. Systematic reviews of randomized controlled trials of cannabinoid products in chronic pain conditions and for symptoms associated with multiple sclerosis: what do they tell us?
    Carlos Vila Silván, C. Vaney, I. Dykukha · 2022 · Expert Review of Clinical Pharmacology
  42. The Effects of Cannabis Among Adults With Chronic Pain
    David A. Gorelick · 2018 · Annals of Internal Medicine
  43. Brief Commentary: Treating Pain—The Cannabis Conundrum
    Chester B. Good, Natasha Parekh, Kavita K. Fischer, James Schuster, Chronis H. Manolis, William Shrank · 2019 · Annals of Internal Medicine
  44. Living Systematic Review on Cannabis and Other Plant-Based Treatments for Chronic Pain: Surveillance Report 3
    Roger Chou, Jesse Wagner, Azrah Y. Ahmed, Benjamin J. Morasco, Devan L. Kansagara, Shelley Selph · 2022
  45. Chronische Schmerzen nehmen weltweit zu
    Andreas Häckel · 2018 · InFo Neurologie + Psychiatrie
  46. Pain Assessment and Management
    Christina L. Vaughan, Alan C. Carver · 2018 · Springer eBooks
  47. Cannabis in chronic pain - An indication supported by scientific evidence?
    Manuel Esteban Codas, Guido Haurón, David Achucarro, Fernando Usher, Marco Antonio Pescador Ruschel, Marcelo Sebriano, Luz Bóveda, Jorge Cabral · 2018 · Revista Virtual de la Sociedad Paraguaya de Medicina Interna
  48. Marijuana: To Use or Not to Use
    Sonal Banzal, Udaya M. Kabadi · 2018 · International Journal of Innovative Research in Medical Science
  49. Brief Commentary: Advocating for Blunt Policy
    Jan Kirk Carney · 2019 · Annals of Internal Medicine
  50. Cannabis for rheumatic pain: hope or hype?
    Glen Stewart Hazlewood, Omid Zahedi Niaki, Mary‐Ann Fitzcharles · 2019 · Clinical Rheumatology
  51. Individualize treatment when prescribing medical cannabis to older patients as efficacy data remains limited
    Adis Medical Writers · 2019 · Drugs & Therapy Perspectives
  52. Cannabis : enjeux et risques en médecine de la douleur
    Anne‐Priscille Trouvin, Serge Perrot · 2019 · Douleur et Analgésie
  53. Opioid and Non-opioid Therapy
    Dermot P. Maher, Bunty J. Shah, Yakov Vorobeychik · 2019 · Springer eBooks
  54. Projets douleur en médecine vétérinaire
    Thiérry Poitte · 2019 · Douleur et Analgésie
  55. Cannabis and the role of the pharmacist
    Darin C. Ramsey · 2020 · Journal of the American Pharmacists Association
  56. Opioid Alternative Medication and Clinical Dilemmas
    Stephen T. Krazit · 2020 · Springer eBooks
  57. Cannabis in Palliative Medicine
    Fabienne Saint-Preux, Arpit Arora, Derek Moriyama, Esther Kim, Arum Kim · 2020 · Springer eBooks
  58. Optimizing the Synergistic Effects of Cannabidiol and Δ9-Tetrahydrocannabinol for the Treatment of Neuropathic Pain in Mouse Behavioural Models
    Fang-Chi Chang, Philip Q. Ding, Stephanie Tam, Lauren R. Xu · 2020 · Undergraduate Research in Natural and Clinical Science and Technology (URNCST) Journal
  59. Illegale Drogen: Welche Arten gibt es und was sind ihre Eigenschaften?
    Nevriye A. Yesil · 2021 · Springer eBooks
  60. Association between marijuana use and nonmedical prescription opioid use in the United States: are we shifting from one epidemic to another?
    Prachi Arora, Andrew J. Johnson, Rasitha R. Jayasekare, Karishma Rohanraj Desai · 2021 · Journal of Public Health Policy
  61. Pain Sensitivity Among Young Adult Recreational Cannabis Users
    Julio Alejandro Yanes, Meredith Amanda Reid, Lauren Yvette Atlas, Jarred Younger, Raúl González, Jennifer L. Robinson · 2020
  62. Utah Controlled Substance Prescribing
    Alexander M. Dydyk, Daniel C. Sizemore, Bhupendra C. K. Patel, Yasmyne C. Ronquillo, Burdett R. Porter · 2021
  63. Medical Cannabis in Chronic Pain Management – Where Are We Now?
    Shamim Haider, WanJane Liew · 2021 · Indian Journal of Pain
  64. Cannabinoids in the rheumatic diseases
    Mary‐Ann Fitzcharles · 2021 · Revista Paulista de Reumatologia
  65. Time to demedicalize marijuana
    Lawrence H. Price · 2021 · The Brown University Psychopharmacology Update
  66. Does Marijuana Increase or Decrease Opioid-Related Dangers?
    2018 · Lippincottʼs Bone and Joint Newsletter
  67. Evidence lacking to support cannabis for treating PTSD, chronic pain
    2017 · The Brown University Psychopharmacology Update
  68. Cannabis
    Mark A. Ware, Rebecca Pitt, Pablo Mauricio Ingelmo · 2021
  69. Does Marijuana Increase or Decrease Opioid-Related Dangers?
    2018 · The Back Letter
  70. 2. Therapeutic Effects and Harms From Cannabis and Cannabinoids
    2021 · American Public Health Association eBooks
  71. The Main Indications for Marijuana Therapy
    2019 · The Back Letter
  72. SOP Dronabinol und andere Cannabinoide in der Schmerztherapie
    Stephan Johannes Ott, Anne Herrmann‐Werner, Stephan Zipfel, Barbara Schlisio · 2022 · PSYCH up2date
  73. Tremendous Misrepresentation and Overvaluing of “Medical Marijuana”
    2022 · The Back Letter
  74. Living Systematic Review on Cannabis and Other Plant-Based Treatments for Chronic Pain: Surveillance Report 2
    Marian S. McDonagh, Jesse Wagner, Azrah Y. Ahmed, Benjamin J. Morasco, Devan L. Kansagara, Roger Chou · 2022
  75. Systematic Review on Acute Treatments for Episodic Migraine: Surveillance Report 1
    Rashmi B. Halker Singh, Juliana H. VanderPluym, Bashar Hasan, Magdoleen H. Farah, Kelly E. Viola, Samer Mohir Saadi, Sahrish H Shah, Tarek Nayfeh, Larry J. Prokop, Mohammed Murad et al. · 2022
  76. Mental disorders are no predictors to determine the duration of cannabis-based treatment for chronic pain
    Caroline Rometsch, Stephan Johannes Ott, Teresa Festl Wietek, Anna-Maria Jurjut, Barbara Schlisio, Stephan Zipfel, Andreas Stengel, Anne Herrmann‐Werner · 2023 · Frontiers in Psychiatry
  77. Medicinal use of Cannabis: Adverse events as a balanced perspective
    Giada Crescioli, Valentina Maggini, Fabio Firenzuoli, Alfredo Vannacci, Niccolò Lombardi · 2023 · Elsevier eBooks
  78. Chronic Abdominal Pain
    Peter Paine, Justin Turner · 2023 · Springer eBooks
  79. The Intersection of Rurality, Unmet Treatment Need, and Cannabis Use for Adults with Chronic Pain
    Hannah S. Appleseth, Desiree Rachel Azizoddin, Amy M. Cohn · 2024 · Cannabis
  80. Addressing the role of endocannabinoid system in rabies infection and its potential for modulation
    Pasin Hemachudha, Thiravat Hemachudha · 2024 · Elsevier eBooks
  81. Cannabis in pain management
    Tahreem Riaz, Muhammad Akram · 2024 · Elsevier eBooks
  82. Posttraumatic stress symptoms moderate the relationship between chronic pain and adverse cannabis outcomes: A pilot study
    Sarah DeGrace, Pablo Romero‐Sanchiz, Sean P. Barrett, Philip G. Tibbo, Tessa Cosman, Pars Atasoy, Sherry H. Stewart · 2024 · Cannabis
  83. Physicochemical Properties, Heavy Metal and Pesticide Contaminations, and Microbial Limit Tests of Cannabis Oral Drops
    Natawat Chankana, Chaowalit Monton, Surang Leelawat, Thanapat Songsak, Worawan Saingam, Fameera Madaka, Athip Maha, Pathamaporn Pathompak · 2024 · Journal of Current Science and Technology
  84. Associations of discomfort intolerance, discomfort avoidance, and cannabis and alcohol use among persons with chronic pain receiving prescription buprenorphine for opioid use disorder
    Danielle F. Haley, Michael D. Stein, Sally Bendiks, Skylar Karzhevsky, Claire Pierce, Ana Dunn, Debra S. Herman, Bradley J. Anderson, Risa B. Weisberg · 2024 · Drug and Alcohol Dependence
  85. Patterns of Nabilone Prescriptions in Canadian Long-Term Care Facilities
    Emily M. Winters, Jennifer L. Gordon, Thomas Hadjistavropoulos · 2024 · Canadian Journal on Aging / La Revue canadienne du vieillissement
  86. Reducing medical cannabis use risk among Veterans: A descriptive study
    Laura M. Harris-Lane, Mitchell R. Sheehy, Courtney A. Loveless, Joshua A. Rash, David Paul Storey, Gregory K. Tippin, Vikas Parihar, Nick Harris · 2025 · Harm Reduction Journal
  87. The Association Between Recreational Cannabis Use and 24‐hour Movement Behaviours: Perceptions of Youth Citizen Scientists
    Tarun Reddy Katapally, Sheriff Tolulope Ibrahim, Jamin Patel · 2025 · Journal of Adolescence
  88. Medical Cannabis for the Treatment of Peripheral Neuropathy
    Justin J. Sherman · 2025 · ADCES in Practice
  89. Interdisciplinary Pain Treatment
    William G. Brose, Dokyoung Sophia You, Corrine Cooley, Allie Schmeissing, Fei Cao · 2025 · Springer eBooks
  90. Marijuana may not be an effective substitute for many chronic pain medications: unobserved variable bias in G-method marginal standardization
    Jacob James Rich, Chad D. Kollas · 2025 · Pain
  91. Prevalence of Cannabidiol (CBD) Use in an Outpatient Hand Surgery Clinic
    Jose M. Iturregui, David G. Deckey, A. Ishimoto, Sean P. Renfree, Shelley S. Noland, Kevin J. Renfree · 2025 · Orthopedics
  92. Additional file 1 of A bibliometric analysis of the cannabis and cannabinoid research literature
    Ng, Jeremy Y., Chang, Nathan · 2022 · Figshare
  93. Additional file 1 of Cannabis against chronic musculoskeletal pain: a scoping review on users and their perceptions
    Daniela Furrer, Kröger, Edeltraut, Martine Marcotte, Nathalie Jauvin, Bélanger, Richard, Ware, Mark, Guillaume Foldes‐Busque, Michèle Aubin, Pierre Pluye, Dionne, Clermont E. · 2021 · Figshare
  94. The Evidence for Medical Cannabis in Chronic Musculoskeletal Pain Management
    Mohammad Khak · 2025 · SurgiColl
  95. Medical Cannabis for the Treatment of Peripheral Neuropathy due to Diabetes: A Systematic Review
    Justin J. Sherman, Daniel M. Riche · 2026 · Cannabis and Cannabinoid Research
  96. Association between cannabis use and insomnia symptoms among veterans with chronic pain
    Jonathan E. Elliott, Daniel Schriemer, Hannah Flegal, Natassja Pal, Meike Niederhausen, Travis I. Lovejoy, Steven K. Dobscha, Benjamin J. Morasco · 2026 · SLEEP Advances
  97. Exploring the pain and substance use in endometriosis: A transactional model investigation with a focus on cannabinoids and opioids
    Guillaume Broc, Margaux Le Borgne, Anthony Gauduchon, Émeline Chauchard · 2026 · Journal of Endometriosis and Pelvic Pain Disorders
  98. Real-world quality of life and sleep outcomes in patients treated with THC- and CBD-rich Cannabis oil: a cross-sectional study
    Janniny Fernanda Lopes Mendes Figueiredo, Christian De Almeida Soares, Dario Alves de Oliveira, Fernando Ribeiro Cassiano, Veronica de Melo Sacramento, Afrânio Farias de Melo Júnior, Elytânia Veiga Menezes, Murilo Malveira Brandão, Vanessa de Andrade Royo · 2026 · Frontiers in Pharmacology
  99. Eficacia del cannabis medicinal en el control del dolor neuropático crónico en adultos: revisión sistemática de la literatura
    Christopher Jahir Bonilla-Jiménez, Rebeca Sarahí Cuadrado-Morales, Kamila Monserrath Durán Cepeda, Emily Valeska Novillo-Fuentes · 2025 · INNOVATE Research Journal
  100. Cannabis Legalization and Opioid Prescribing in Veterans Health Administration Patients: 2013–2022
    Zachary L. Mannes, Melanie M. Wall, Malki Stohl, Carol A. Malte, Mark Olfson, Ofir Livne, David S. Fink, Tracy Simpson, Caroline G. Wisell, Salomeh Keyhani et al. · 2026 · Journal of General Internal Medicine