High-order social interactions in groups of mice
Open accessAbstract
Social behavior in mammals is often studied in pairs under artificial conditions, yet groups may rely on more complicated social structures. Here, we use a novel system for tracking multiple animals in a rich environment to characterize the nature of group behavior and interactions, and show strongly correlated group behavior in mice. We have found that the minimal models that rely only on individual traits and pairwise correlations between animals are not enough to capture group behavior, but that models that include third-order interactions give a very accurate description of the group. These models allow us to infer social interaction maps for individual groups. Using this approach, we show that environmental complexity during adolescence affects the collective group behavior of adult mice, in particular altering the role of high-order structure. Our results provide new experimental and mathematical frameworks for studying group behavior and social interactions. DOI:http://dx.doi.org/10.7554/eLife.00759.001.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The authors previously developed an experimental system that allows animals to behave freely in a large enriched environment while their location is tracked automatically over days and dozens of behavioral readouts are extracted.
“we previously developed an experimental system that allows animals to behave freely in a large environment, enriched with hiding places, elevated platforms, bedding, feeders, and water sources, while their location is tracked automatically over days, and dozens of behavioral readouts are extracted”
From Wireless Optogenetic Stimulation of Oxytocin Neurons in a Semi-natural Setup Dynamically Elevates Both Pro-social and Agonistic Behaviors (2020) · cites this paper as Shemesh et al., 2013
Early studies in the arenas showed that mice would spend on average 1-2 hr in the feeder zones when food was freely available.
“This time frame was chosen based on data from early studies in the arenas that showed mice would spend on average 1-2 hr in the feeder zones when food was freely available (Shemesh et al., 2013).”
From Wireless Optogenetic Stimulation of Oxytocin Neurons in a Semi-natural Setup Dynamically Elevates Both Pro-social and Agonistic Behaviors (2020) · cites this paper as Shemesh et al., 2013
In the laboratory, mice are more often than rats kept in large groups (more than 10 animals), which facilitates studying high-order social behaviors such as emergence of social networks.
“Finally, in the laboratory, mice are more often than rats kept in large groups (ie, more than 10 animals), which facilitates studying high-order social behaviors which cannot be reduced to interactions within dyads, for example, emergence of social networks.1,2,72”
From Ecological validity of social interaction tests in rats and mice (2019) · cites this paper as [2]
In a recent study, groups of laboratory mice tracked in a complex environment were relatively more individualistic after some time than mice kept in standard conditions.
“The correlation of group behavior gradually increased with time, but only in the former case-in other words, after some time the mice in complex environment were relatively more individualistic than the ones kept in standard conditions.2”
From Ecological validity of social interaction tests in rats and mice (2019) · cites this paper as [2]
Automated systems for measuring social interactions in group-living animals are becoming more and more popular.
“Such systems are becoming more and more popular.1,2,179”
From Ecological validity of social interaction tests in rats and mice (2019) · cites this paper as [2]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
The citation lists haven’t been fetched yet
References 55 · Cited by 213
Research works printed but not linked: 1
- Landau L Lifshitz E 1980 Statistical physics. 3rd Ed Oxford: Pergamon Press
- Authors
- Shemesh, Y., Sztainberg, Y., Forkosh, O., Shlapobersky, T., Chen, A., & Schneidman, E.
- Affiliations
- Weizmann Institute of Science (IL)
- Max Planck Institute of Psychiatry (DE)
- Corresponding author
- Chen, Alon
- Schneidman, Elad
- Venue
- eLife
- Publisher
- eLife Sciences Publications, Ltd
- Published
- 2013-09-03
- Volume
- 2
- Pages
- e00759-e00759
- ISSN
- 2050-084X (ISSN-L)
- PMC
- PMC3762363
- OpenAlex
- W1980351491
- Cited by
- 213
- References
- 55
- Citations by year
- 2026: 11 · 2025: 17 · 2024: 11 · 2023: 40 · 2022: 23 · 2021: 22 · 2020: 19 · 2019: 16 · 2018: 15 · 2017: 13 · 2016: 10 · 2015: 8 · 2014: 7 · 2013: 1
- FWCI
- 9.18
- Type
- journal article
- Language
- en
- Update notices
- correction (2014-06-11)
- Open access
- gold
- doi.org
- Licence
- Locations
- eLife (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Max Planck Digital Library (submittedVersion)
- MPG.PuRe (Max Planck Society) (submittedVersion, cc-by)
- Funders
- Templeton Positive Neuroscience award
- European Research Council (FP7 grant, #260463)
- Israel Science Foundation
- Roberto and Renata Ruhman
- Legacy Heritage Biomedical Science Partnership
- Human Frontier Science Program
- John Templeton Foundation
- Topics
- Life Sciences › Agricultural and Biological Sciences › Ecology, Evolution, Behavior and Systematics › Animal Behavior and Reproduction
- Social Sciences › Psychology › Social Psychology › Primate Behavior and Ecology
- Social Sciences › Psychology › Social Psychology › Neuroendocrine regulation and behavior
- Keywords
- group behavior, social interaction, mice, higher-order interactions, collective behavior, environmental complexity, adolescence, animal tracking, two-particle correlations, social structure
- MeSH terms
- Animals, Social Behavior, Ultraviolet Rays, Mice
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
