The DOI matches its Crossref record; 52 of the 52 references it cites were found in a registry or an index.
Interplay of cell dynamics and epithelial tension during morphogenesis of the Drosophila pupal wing
Open accessAbstract
How tissue shape emerges from the collective mechanical properties and behavior of individual cells is not understood. We combine experiment and theory to study this problem in the developing wing epithelium of Drosophila. At pupal stages, the wing-hinge contraction contributes to anisotropic tissue flows that reshape the wing blade. Here, we quantitatively account for this wing-blade shape change on the basis of cell divisions, cell rearrangements and cell shape changes. We show that cells both generate and respond to epithelial stresses during this process, and that the nature of this interplay specifies the pattern of junctional network remodeling that changes wing shape. We show that patterned constraints exerted on the tissue by the extracellular matrix are key to force the tissue into the right shape. We present a continuum mechanical model that quantitatively describes the relationship between epithelial stresses and cell dynamics, and how their interplay reshapes the wing.
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The Influence of Cell Mechanics, Cell-Cell Interactions, and Proliferation on Epithelial Packing
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Self-citationForces in Tissue Morphogenesis and Patterning
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Self-citationProgrammed and self-organized flow of information during morphogenesis
Collinet, C., & Lecuit, T. (2021) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-020-00318-6 · Cited by 322
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Metadata
- Authors
- Etournay, R., Popović, M., Merkel, M., Nandi, A., Blasse, C., Aigouy, B., Brandl, H., Myers, G., Salbreux, G., Jülicher, F., & Eaton, S.
- Venue
- eLife
- Publisher
- eLife Sciences Publications, Ltd
- Published
- 2015-06-23
- Volume
- 4
- Pages
- e07090-e07090
- ISSN
- 2050-084X (ISSN-L)
- OpenAlex
- W2114187112
- Cited by
- 373
- References
- 52
- FWCI
- 15.88
- Type
- journal article
- Language
- en
- Open access
- gold
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- Etournay, R., Popović, M., Merkel, M., Nandi, A., Blasse, C., Aigouy, B., Brandl, H., Myers, G., Salbreux, G., Jülicher, F., & Eaton, S. (2015). Interplay of cell dynamics and epithelial tension during morphogenesis of the Drosophila pupal wing. eLife. https://doi.org/10.7554/elife.07090
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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