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Cited by 2Ion channel regulation and functionNeural dynamics and brain functionNeuroscience and Neuropharmacology Research

Relative timescale of channel voltage dependence and channel density regulation impacts assembly and recovery of activity

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Mondal, Yugarshi, Calabrese, Ronald L, Marder, Eve·2025·eLife
DOI 10.7554/elife.105842PMC PMC12582563

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Abstract

Neurons can maintain stable activity profiles over their lifetimes despite ion channel turnover over minutes to weeks. Neuronal activity is also influenced by regulating the voltage dependence of ion channels. How do these two forms of plasticity work together to maintain a stable activity profile? We augment a classical model of activity-dependent ion channel density regulation with a mechanism that adjusts channel voltage dependence based on activity. These findings reveal that the timescale of these mechanisms shapes the specific electrical activity patterns that achieve a target activity profile. Moreover, alterations in channel voltage dependence can impact a neuron’s ability to recover from perturbations. These results highlight a potentially distinct role for activity-dependent regulation of channel voltage dependence in maintaining stable neuronal activity profiles.

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  • Degeneracy can be produced in models with the same types of currents, but different numbers of channels, variable sets of voltage dependences of channels, or as a function of other parameters controlling channel function.

    “Degeneracy can be produced in models with the same types of currents, but different numbers of channels [32,33], variable sets of voltage dependences of channels [35-37], or as a function of other parameters controlling channel function.”

    From A feature and not a bug: Replication failures can lead to new biology (2026) · cites this paper as [36]

  • In this model, channel density and the voltage-dependence of ion channels are both regulated to maintain stable performance of a model neuron.

    “In this model, channel density and the voltage-dependence of ion channels are both regulated to maintain stable performance of a model neuron.”

    From A feature and not a bug: Replication failures can lead to new biology (2026) · cites this paper as [36]

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Cited by

Sorted by citations

Authors
Mondal, Y., Calabrese, R. L., & Marder, E.
Affiliations
  • Brandeis University (US)
  • Emory University (US)
Corresponding author
Mondal, Yugarshi
ORCID
Venue
eLife
Publisher
eLife Sciences Publications, Ltd
Published
2025-11-03
Volume
14
ISSN
2050-084X (ISSN-L)
DOI
10.7554/elife.105842
PMC
PMC12582563
OpenAlex
W4409077812
Cited by
2
References
0
Citations by year
2026: 1 · 2025: 1
Type
posted content
Language
en
Open access
Licence
Locations
  • eLife (publishedVersion, cc-by)
  • Europe PMC (PubMed Central) (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Funders
  • National Institute of Mental Health (R01MH046742)
  • National Institute of Neurological Disorders and Stroke (R35NS097343)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Ion channel regulation and function
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Keywords
activity-dependent plasticity, neuronal excitability, computational neuron model
MeSH terms
Action Potentials, Animals, Ion Channels, Neuronal Plasticity, Neurons, Time Factors, Ion Channel Gating

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