Stochastic and deterministic dynamics of intrinsically irregular firing in cortical inhibitory interneurons
Open accessAbstract
Most cortical neurons fire regularly when excited by a constant stimulus. In contrast, irregular-spiking (IS) interneurons are remarkable for the intrinsic variability of their spike timing, which can synchronize amongst IS cells via specific gap junctions. Here, we have studied the biophysical mechanisms of this irregular spiking in mice, and how IS cells fire in the context of synchronous network oscillations. Using patch-clamp recordings, artificial dynamic conductance injection, pharmacological analysis and computational modeling, we show that spike time irregularity is generated by a nonlinear dynamical interaction of voltage-dependent sodium and fast-inactivating potassium channels just below spike threshold, amplifying channel noise. This active irregularity may help IS cells synchronize with each other at gamma range frequencies, while resisting synchronization to lower input frequencies.
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Irregular neuronal firing may be caused by intrinsic cellular mechanisms through the stochastic gating of ion channels in the membrane, such as potassium ion channels.
“Second, irregular neuronal firing may be caused by intrinsic cellular mechanisms through the stochastic gating of ion channels in the membrane, such as potassium ion channels [70–73].”
From Chronic unpredictable stress induces depression-related behaviors by suppressing AgRP neuron activity (2021) · cites this paper as [71]
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References 72 · Cited by 37
Research works printed but not linked: 1
- Alonso G Widmer H 1997 Clustering of KV4.2 potassium channels in postsynaptic membrane of rat supraoptic neurons: an ultrastructural study Neuroscience 77 617 621 9070739
- Authors
- Mendonça, P. R., Vargas-Caballero, M., Erdélyi, F., Szabó, G., Paulsen, O., & Robinson, H. P.
- Affiliations
- University of Cambridge (GB)
- Institute for Life Sciences, University of Southampton, Southampton, United Kingdom
- HUN-REN Institute of Experimental Medicine (HU)
- Corresponding author
- Robinson, Hugh PC
- ORCID
- Venue
- eLife
- Publisher
- eLife Sciences Publications, Ltd
- Published
- 2016-08-18
- Volume
- 5
- ISSN
- 2050-084X (ISSN-L)
- PMC
- PMC5030087
- OpenAlex
- W2515400174
- Cited by
- 37
- References
- 72
- Citations by year
- 2026: 4 · 2024: 12 · 2023: 3 · 2022: 3 · 2021: 6 · 2020: 3 · 2019: 2 · 2018: 1 · 2017: 2 · 2016: 1
- FWCI
- 1.27
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- eLife (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- ePrints Soton (University of Southampton) (acceptedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- UCL Discovery (University College London) (submittedVersion)
- Apollo (University of Cambridge) (submittedVersion, cc-by)
- Apollo (cc-by)
- Funders
- Biotechnology and Biological Sciences Research Council
- Coordenação de Aperfeiçoamento de Pessoal de Nível Superior
- Cambridge Overseas Trust
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
- Physical Sciences › Physics and Astronomy › Statistical and Nonlinear Physics › stochastic dynamics and bifurcation
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Keywords
- cortical inhibitory interneurons, nonlinear dynamics, gamma oscillations, network synchronization, spike threshold
- MeSH terms
- Action Potentials, Animals, Cerebral Cortex, Computer Simulation, Interneurons, Models, Neurological, Potassium Channels, Nonlinear Dynamics, Patch-Clamp Techniques, Mice, Biophysical Phenomena, Voltage-Gated Sodium Channels
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