The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
A novel optical microscope for imaging large embryos and tissue volumes with sub-cellular resolution throughout
Open accessAbstract
Current optical microscope objectives of low magnification have low numerical aperture and therefore have too little depth resolution and discrimination to perform well in confocal and nonlinear microscopy. This is a serious limitation in important areas, including the phenotypic screening of human genes in transgenic mice by study of embryos undergoing advanced organogenesis. We have built an optical lens system for 3D imaging of objects up to 6 mm wide and 3 mm thick with depth resolution of only a few microns instead of the tens of microns currently attained, allowing sub-cellular detail to be resolved throughout the volume. We present this lens, called the Mesolens, with performance data and images from biological specimens including confocal images of whole fixed and intact fluorescently-stained 12.5-day old mouse embryos.
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A mesoscale connectome of the mouse brain
Oh, S. W., Harris, J. A., Ng, L., Winslow, B., Cain, N., Mihalas, S., Wang, Q., Lau, C., Kuan, L., Henry, A. M., et al. (2014) · Nature · doi:10.1038/nature13186 · Cited by 2,612
Cited by
In vivo imaging of neural activity
Yang, W., & Yuste, R. (2017) · Nature Methods · doi:10.1038/nmeth.4230 · Cited by 406
Metadata
- Authors
- McConnell, G., Trägårdh, J., Amor, R., Dempster, J., Reid, E., & Amos, W. B.
- Venue
- eLife
- Publisher
- eLife Sciences Publications, Ltd
- Published
- 2016-09-23
- Volume
- 5
- ISSN
- 2050-084X (ISSN-L)
- OpenAlex
- W2521880954
- Cited by
- 164
- References
- 1
- FWCI
- 6.59
- Type
- journal article
- Language
- en
- Open access
- gold
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- McConnell, G., Trägårdh, J., Amor, R., Dempster, J., Reid, E., & Amos, W. B. (2016). A novel optical microscope for imaging large embryos and tissue volumes with sub-cellular resolution throughout. eLife. https://doi.org/10.7554/elife.18659
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