The DOI matches its Crossref record; 5 of the 5 references it cites were found in a registry or an index.
Reciprocal analyses in zebrafish and medaka reveal that harnessing the immune response promotes cardiac regeneration
Open accessAbstract
Zebrafish display a distinct ability to regenerate their heart following injury. However, this ability is not shared by another teleost, the medaka. In order to identify cellular and molecular bases for this difference, we performed comparative transcriptomic analyses following cardiac cryoinjury. This comparison points to major differences in immune cell dynamics between these models. Upon closer examination, we observed delayed and reduced macrophage recruitment in medaka, along with delayed neutrophil clearance. To investigate the role of immune responses in cardiac regeneration, we delayed macrophage recruitment in zebrafish and observed compromised neovascularization, neutrophil clearance, cardiomyocyte proliferation and scar resolution. In contrast, stimulating Toll-like receptor signaling in medaka enhanced immune cell dynamics and promoted neovascularization, neutrophil clearance, cardiomyocyte proliferation and scar resolution. Altogether, these data provide further insight into the complex role of the immune response during regeneration, and serve as a platform to identify and test additional regulators of cardiac repair.
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Cites
Trimmomatic: a flexible trimmer for Illumina sequence data
Bolger, A. M., Lohse, M., & Usadel, B. (2014) · Bioinformatics · doi:10.1093/bioinformatics/btu170 · Cited by 65,548
STAR: ultrafast universal RNA-seq aligner
Dobin, A., Davis, C. A., Schlesinger, F., Drenkow, J., Zaleski, C., Jha, S., Batut, P., Chaisson, M., & Gingeras, T. R. (2013) · Bioinformatics · doi:10.1093/bioinformatics/bts635 · Cited by 51,709
featureCounts: an efficient general purpose program for assigning sequence reads to genomic features
Liao, Y., Smyth, G. K., & Shi, W. (2014) · Bioinformatics · doi:10.1093/bioinformatics/btt656 · Cited by 27,219
Hippo signaling impedes adult heart regeneration
Heallen, T., Morikawa, Y., Leach, J., Tao, G., Willerson, J. T., Johnson, R. L., & Martin, J. F. (2013) · Development · doi:10.1242/dev.102798 · Cited by 458
Li, L., Yan, B., Shi, Y.-Q., Zhang, W.-Q., & Wen, Z.-L. (2012) · Journal of Biological Chemistry · doi:10.1074/jbc.m112.349126 · Cited by 353 · cited 1×
“Neutrophils were more abundant than macrophages at this stage, consistent with observations in the fin amputation model ( Li et al., 2012 ).”
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Cited by
The Macrophage in Cardiac Homeostasis and Disease
Lavine, K. J., Pinto, A. R., Epelman, S., Kopecky, B. J., Clemente-Casares, X., Godwin, J., Rosenthal, N., & Kovacic, J. C. (2018) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2018.08.2149 · Cited by 234
Longitudinal in vivo imaging of adult Danionella cerebrum using standard confocal microscopy
Lam, P.-Y. (2022) · Disease Models & Mechanisms · doi:10.1242/dmm.049753 · Cited by 33
Rao, A., Lyu, B., Jahan, I., Lubertozzi, A., Zhou, G., Tedeschi, F., Jankowsky, E., Kang, J., Carstens, B., Poss, K. D., et al. (2023) · Development · doi:10.1242/dev.201376 · Cited by 13
Metadata
- Authors
- Lai, S.-L., Marín-Juez, R., Moura, P. L., Kuenne, C., Lai, J. K. H., Tsedeke, A. T., Guenther, S., Looso, M., & Stainier, D. Y.
- Venue
- eLife
- Publisher
- eLife Sciences Publications, Ltd
- Published
- 2017-06-20
- Volume
- 6
- ISSN
- 2050-084X (ISSN-L)
- OpenAlex
- W2697082363
- Cited by
- 289
- References
- 5
- FWCI
- 10.87
- Type
- journal article
- Language
- en
- Open access
- gold
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