The DOI matches its Crossref record; 9 of the 9 references it cites were found in a registry or an index.
A novel source of arterial valve cells linked to bicuspid aortic valve without raphe in mice
Open accessAbstract
Abnormalities of the arterial valve leaflets, predominantly bicuspid aortic valve, are the commonest congenital malformations. Although many studies have investigated the development of the arterial valves, it has been assumed that, as with the atrioventricular valves, endocardial to mesenchymal transition (EndMT) is the predominant mechanism. We show that arterial is distinctly different from atrioventricular valve formation. Whilst the four septal valve leaflets are dominated by NCC and EndMT-derived cells, the intercalated leaflets differentiate directly from Tnnt2-Cre+/Isl1+ progenitors in the outflow wall, via a Notch-Jag dependent mechanism. Further, when this novel group of progenitors are disrupted, development of the intercalated leaflets is disrupted, resulting in leaflet dysplasia and bicuspid valves without raphe, most commonly affecting the aortic valve. This study thus overturns the dogma that heart valves are formed principally by EndMT, identifies a new source of valve interstitial cells, and provides a novel mechanism for causation of bicuspid aortic valves without raphe.
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Cites
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Mutations in NOTCH1 cause aortic valve disease
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Tie2-Cre Transgenic Mice: A New Model for Endothelial Cell-Lineage Analysis in Vivo
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Large-scale neural recordings with single neuron resolution using Neuropixels probes in human cortex
Paulk, A. C., Kfir, Y., Khanna, A. R., Mustroph, M. L., Trautmann, E. M., Soper, D. J., Stavisky, S. D., Welkenhuysen, M., Dutta, B., Shenoy, K. V., et al. (2022) · Nature Neuroscience · doi:10.1038/s41593-021-00997-0 · Cited by 283
Self-citationHuman pluripotent stem cell–derived brain pericyte–like cells induce blood-brain barrier properties
Stebbins, M. J., Gastfriend, B. D., Canfield, S. G., Lee, M.-S., Richards, D., Faubion, M. G., Li, W.-J., Daneman, R., Palecek, S. P., & Shusta, E. V. (2019) · Science Advances · doi:10.1126/sciadv.aau7375 · Cited by 195
Moulton, M. J., Barish, S., Ralhan, I., Chang, J., Goodman, L. D., Harland, J. G., Marcogliese, P. C., Johansson, J. O., Ioannou, M. S., & Bellen, H. J. (2021) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2112095118 · Cited by 180
Metadata
- Authors
- Eley, L., Alqahtani, A. M., MacGrogan, D., Richardson, R. V., Murphy, L., Salguero-Jimenez, A., Sintes Rodriguez San Pedro, M., Tiurma, S., McCutcheon, L., Gilmore, A., de La Pompa, J. L., Chaudhry, B., & Henderson, D. J.
- Venue
- eLife
- Publisher
- eLife Sciences Publications, Ltd
- Published
- 2018-06-29
- Volume
- 7
- ISSN
- 2050-084X (ISSN-L)
- OpenAlex
- W2810440784
- Cited by
- 1,138
- References
- 9
- FWCI
- 43.08
- Type
- journal article
- Language
- en
- Open access
- gold
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- Eley, L., Alqahtani, A. M., MacGrogan, D., Richardson, R. V., Murphy, L., Salguero-Jimenez, A., Sintes Rodriguez San Pedro, M., Tiurma, S., McCutcheon, L., Gilmore, A., de La Pompa, J. L., Chaudhry, B., & Henderson, D. J. (2018). A novel source of arterial valve cells linked to bicuspid aortic valve without raphe in mice. eLife. https://doi.org/10.7554/elife.34110
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
